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11 Cards in this Set
- Front
- Back
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citrate in glycolysis
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inhibits PFK1
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H+ in glycolysis
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INHIBITS PFK1
the conversion of the aldehyde to carboxylic acid in glycolysis (glyceraldehyde 3-phosphate dehydrogenase) generates H+ don't want it shutting things down, now |
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Fructose 2,6-bisphosphate does what to PFK1
and what to fructose 1,6-biphosphatase |
activates PFK1
inhibits Fructose 1,6-biphosphatase (the gluconeogenesis enzyme) |
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the enzyme that makes Fructose 2,6-bisphosphate
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PFK2
fructose 2,6-bisphosphatase is on the same protein complex as PFK2 |
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what switches PFK2/fructose 2,6-biphosphatase back and forth, off and on
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glucagon
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Glucokinase
high or low Km for glucose |
very high Km for glucose
= low affinity |
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what is the feed-forward stimulator molecule for pyruvate kinase
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fructose 1,6-bisphosphate
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the main controller of pyruvate carboxylase
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AcCoA
signals fatty acid breakdown (starvation) and the need for glucose OR depletion of TCA intermediates, in which case OAA is needed from the neoglucogenic pathways |
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what keeps the glucose made neoglucogenically from being consumed right there by the glycolytic cycle
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pyruvate kinase is inhibited by AcCoA and Alanine
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high AcCoA signals what
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starvation, breakdown of FA's
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during starvation or fatty acid breakdown, how do you prevent pyruvate from going into the TCA cycle when it is needed for gluconeogenesis
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pyruvate dehydrogenase is inhibited by AcCoA
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