Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
27 Cards in this Set
- Front
- Back
|
PLP is derived from...
|
Vitamin B6
|
|
|
Sulfanilamide drugs competitively inhibit synthesis of...
|
folic acid in microorganisms
|
|
|
Methotrexate
|
Folic acid analogue
comp inhibits dehydrofolate reductase (DNA replication) |
|
|
Protein turnover per day
|
400 g
|
|
|
Proteosomes
|
degrade intracelluar proteins
protein is marked by covalent bond to ubiquitin (which is recycled) |
|
|
Lysosomes
|
degrade proteins, fats, carbs, NA
ph of 5 cathepsin proteinases |
|
|
Kwashiorkor
|
proteini deprivation
stunted growth,edema,skinlesions,plump belly |
|
|
Marasmus
|
calorie deprivation
no edema |
|
|
Parietal cells
|
secrete HCl via H/KATPase
pH 2 |
|
|
Chief cells
|
secrete pepsinogen which activates to pepsin-->activated by HCl
|
|
|
H2 receptors
|
histamine receptors
stimulate HCl secretion |
|
|
Pepsin cleaves..
|
on C terminal of Leu, Phe and Tyr
|
|
|
Secretin
|
stimulates release of HCO-3 in gastric juices-->ph 8
|
|
|
Cholecystokinin
|
stimulates release of protease zymogens (effective at ph 8)
causes release of bile fluid |
|
|
Enteropeptidase
|
made by intestinal mucosal cells
converts trypsinogen to trypsin |
|
|
secretory trypsin inhibitor
|
secreted by pancrease to avoid premature activation of trypsin.
Overwhelmed by large amounts of enteropeptidase |
|
|
Trypsin cleaves
|
Arg and Lys
|
|
|
Chymotrypsin
|
Trp,Tyr,Phe,Leu,Met
|
|
|
Elastase
|
Ala,Gly,Ser
|
|
|
C-peptidase cleaves
|
Ala,Ile,Leu,Val
|
|
|
C-peptidase
|
Arg, Lys
|
|
|
aminopeptidase
|
exopeptidase on luminal surface of the intestine that repeatedly cleaves the N term of olgiopeptides
|
|
|
enterocytes
|
intestinal cells that take up proteins
use Na-AA cotransporter |
|
|
Hartnups Disease
|
loss of fn of transporter SLC6A19
loss of Trp uptake-->limits avail for naicin syn.-->pellegra like symptoms |
|
|
Cystinuria
|
loss of SLC3A1/SLC7A9
unable to recover cystine from urine-->stones Cystine Orthinine Arginine Lysine |
|
|
Dipeptide/Tripeptide uptake
|
via H electrochemical gradient
further broken down by enterocytes |
|
|
5-Oxyproilinuria
|
deficiency in GSH synthetase
|
