Misc Biochem Test 1

Front 1

Remicade

Back 1

Aka Inflixamib

Humanized Fab on human IgG

binds TNF alpha and treats inflammatory diseases like Crohns

Front 2

When is HIV western blot positive?

Back 2

p31 or p24

AND

gp 160 or gp120

Front 3

Where does enteropeptidase cleave?

Back 3

At lysines preceded by 4 Aspargines

Cleaves trypsinogen to trypsin

Front 4

ALP

Back 4

Alkaline phosphatase--
if in blood, can be a marker for rapid bone growth or bone disease (eg, rickets)

Front 5

AST

Back 5

Aspartate Aminotranferase
Found in the liver
uses pyroxidal phosphate as an enzyme
Can detect liver damage (amt of damage directly related to amt of AST in blood)
alcoholic hepatitis indicated if AST/ALT > 2

Front 6

ALT

Back 6

Alanine Aminotransferase
another liver enzyme marker

tests disease OR if drugs are damaging liver

Front 7

Enzyme markers for MI

Back 7

BM form of creatine kinase
Now, myoglobin (appears in 2 hours) and troponin (lasts 2 weeks)

Front 8

Serum amylase levels elevated indicates?

Back 8

pancreatic duct obstruction or pancreatic cancer

Front 9

Abatacept

Back 9

Rheumatoid Arthritis
Binds to CD28 on T cell so it can't be costimulated
Decreases production of T cell derived cytokines

Front 10

Rituximab

Back 10

For B-cell non-Hodgkins lymphoma, B-cell leukemia

Targets CD20 on B cells

Front 11

Prolastin/Aralast

Back 11

for A1-AT deficiency

A1P1 is a proteinase inhibitor

Front 12

Activated C protein

Back 12

for sepsis

Front 13

Factor VIIa

Back 13

Hemophilia

NovoSeven RT- activates X directly, so bypasses problems with VIII and IX

Front 14

TPA

Back 14

activates plasminogen

for treatment of MI, stroke, pulmonary embolism

works at clot sites- not a whole body anticoagulant

Front 15

Granulocyte CSF

Back 15

stimulates bone marrow to produce granulocytes

for chemo induced neutropenia