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25 Cards in this Set
- Front
- Back
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PNS NEUROTRANSMITTER
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pre and post acetylcholine
ratio 1 : 1 |
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PNS RECEPTOR
NICOTINIC |
-all autonomic ganglion cells
-adrenal medulla -neurotransmitter junction |
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PNS RECEPTOR
MUSCARINIC |
-all effector organs innervated by post ganglionic
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SNS NEUROTRANSMITTER
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-preganglionic - acetylcholine
-postganglionic - norepinephrine (except sweat glands) ratio 1: 20 |
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SNS RECEPTOR
ALPHA |
-excitatory (except in GI tract where inhibitory)
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SNS RECEPTOR
BETA |
-inhibitory (except in heart where excitatory)
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SNS RECEPTOR
BETA 1 AND BETA 2 |
B1 - cardiac
B2 - bronchi and blood vessels |
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EFFERENT SIGNALS
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-signals travel through sympathetic and parasympathetic fibers
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SYMPATHETIC FIBERS
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central
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PARASYMPATHETIC FIBERS
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cervical and sacral (mostly cranial nerves)
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PREGANGLIONIC FIBERS IN BOTH PNS AND SNS
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-cholinergic
(acetylcholine) |
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POSTGANGLIONIC FIBERS IN PNS
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-cholinergic
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MOST POSTGANGLIONIC FIBERS IN SNS
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-adrenergic
(norepinephrine) some are cholinergic |
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RECEPTORS FOR ACh
(MUSCARINIC) |
-effector cells stimulated by the post ganglionic neurons in BOTH the SNS and PNS
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NICOTINIC RECEPTORS
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-found in the synapses between the pre and post ganglionic neurons of both the SNS and PNS
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NOREPINEPHRINE
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mainly stimulates the alpha receptors and in a lesser way the beta receptors
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EPINEPHRINE
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stimulates both alpha and beta receptors equally
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SNS AGONIST AND WHAT IT DOES
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epinephrine, norepinephrine, and dobutamine
-raises blood pressure, increases HR, and contractility fight or flight response |
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ALPHA 1 RECEPTOR
AGONIST (+), ANTAGONIST (-) AND ACTION |
+epinephrine and norepinephrine
(-) prazosin ACTION- vasoconstriction (raises BP), intestinal relaxation, pupillary dilation |
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ALPHA 2 RECEPTOR (+), (-), AND ACTION
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(+) clonidine
(-) Yohimbine ACTION - Blocks the presynaptic release of NE from adrenergic (SNS) nerves, has a sympathetic action on the brainstem |
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BETA 1 RECEPTOR (+), (-), AND ACTION
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(+) E and NE
(-) Metoprolol ACTION - cardiac stimulation (^ HR and contractility) lipolysis |
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BETA 2 RECEPTOR (+), (-), AND ACTION
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(+) E > NE
(-) non selective beta blockers ACTION - vasodilation and bronchodilation |
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DOPAMINE 1 RECEPTOR (+), (-), AND ACTION
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(+) Dopamine
(-) Phenothiazines, and thioxanthenes ACTION - vasodilation of renal coronary, and cerebral vasc beds |
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DOPMINE 2 RECEPTOR (+), (-) ACTION
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(+) Dopamine
(-) Haloperidol ACTION - Inhibits transmission in SNS ganglia and NE release from SNS nerve endings |
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PARASYMPATHETIC NERVOUS SYSTEM (+), (-), ACTION
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(+) ACh, bethanechol, cholinesterase inhibitors (physotigmine, edrophonium, neostigmine)
(-) atropine and scopolamine ACTION - Cardiac effects - through the vagus nerve ACh slows HR and conduction through the AV node (little direct reg of contractility and PVR) -Non cardiac effects - increase GI and GU motility and relaxation of sphincters - bronchoconstriction, and increase bronchial secretions |
