Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
what is the definition of asthma
|
a chronic inflammatory disease of the airways
causing recurrent episodes of wheezing,breathlessness, chest tightness, and cough, particularly at night and/or in the early morning. These sx are reversible and assocaited with BHR due to stimulus |
|
|
what are the pathophysiological changes in pt with asthma
|
airway smooth-muscle contraction, hypertrophy and hyperplasia, microvascular leakage, activation of airway neurons, stimulation of
mucus-secreting cells, disruption of the ciliated epithelium, and the laying down of collagen in the lamina reticularis of the basement membrane layer. |
|
|
what cells are found to infiltrate airway in asthma
|
mast cells
EOS activated T cells Neutrophils |
|
|
what is the role of mast cells in asthma inflammation
|
Mast cells due to IgE stimulated release histmaine and LT and PG which are bronchoconstrictors, produce mucus
|
|
|
what is the key factor in bronchial hyperairway
|
airwy inflammation- response to variety of stimuli- cold air, histmaine, methachoile, envt irritants
|
|
|
how do we check for degree of bronchial hyperactivity
|
standard inhaltion test with methachoilne, histamineinhaltion test
|
|
|
how does methachoilne/histamine result in airway narrowing
|
it acts directly on airway smooth muscle
|
|
|
how does exercise and hypersomolar substance casue airway narrowing
|
release pharmaological active substance from mast cells
|
|
|
what are the cause for airway obstruction in asthma
|
Acute bronchoconstriction
Mucus plugging of airways Bronchial wall edema Infl ammatory cell infi ltration Airway wall remodeling (fibrosis) Smooth-muscle hypertrophy Uncoupling of elastic recoil forces |
