Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
etiology of asthma
|
mucus plug, edema, bronchoconstriction, cellular infiltration
|
|
|
cardinal feature of most athmatics
|
non specific bronchial hyperreactivity
|
|
|
mechanism of beta agonist in bronchodilation
|
activate adenylate cyclase => elevate cAMP levels
|
|
|
mechanism of theophylline
|
- phosphodiesterase inhibitor
- adenosine antagonist |
|
|
ipratropium mechanism of action
|
antimuscarinic => bronchodilation
antimuscarinic and b2 agonist are equal in COPD patient, but b2>antimuscarinics for asthma |
|
|
cromolyn
|
- poorly absorbed across mucosal membranes
- prevent late asthmatic response to inhaled allergen - does not affect cAMP - inhibit mast cell release in response to non-specific stimuli.. acts directly on mast cell membranes |
|
|
mechanism of corticosteroids (beclamethasone)
|
- no direct bronchodilator effect
- affect secretion of mediators and inflammatory component |
|
|
zileuton
|
inhibits leukotriene formation by inhibiting 5-lipoxygenase
|
|
|
zafirlukast
montelukast |
block binding of LTD4 to its receptors
|
