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37 Cards in this Set

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Phenytoin MOA
(Dilantin)
Na channel blocker
"Low salt on Carbs is Lame and not Phun unless I have a Part Gin/Tonic"
Phenytoin Indication
DOC:
Partial seizures
Generalized tonic-clonic
Status epilepticus
Trigeminal neuralgia
Cardiac Arrhythmias
Phenytoin Metabolism
Highly plasma & tissue bound -> widely distributed
Conjugated -> inactive metabolites -> excreted in urine
Low dose -> FOK (T1/2 = 24 hrs)
High dose -> ZOK (saturates liver enzymes)
Phenytoin mnemonic
"Having such a Phun time killing babies (teratogenic) w/ Partial Gin/Tonic my heart skipped a beat (tx arrhythmias) I stated I had a headache (Trigem Neuralgia) & my dick in a chain which ANGHRS HM
Phenytoin SE
ANGHRS HM:
Ataxia
Nystagmus
Gingival Hyperplaisa
Rash
SJS
Hepatitis
Megaloblastic Anemia
Phenytoin Drug Interactions
Drug interactions:
Dicumarol, cimetadine, valproic acid -> inhibit metabolism
Barbiturates, carbamazepine -> ↑ metabolism
Phenytoin -> ↑ metabolism of carbamazepine, dicumarol, oral contraceptives, cyclosporine
Carbamazepine
(Tegretol)
Na channel blocker
"Low salt on Carbs is Lame and not Phun unless I have a Part Gin/Tonic"
Carbamazepine indications
(Tegretol)
DOC:
Partial seizures Generalized tonic-clonic

Severe cases -> w/ phenytoin

Trigeminal neuralgia
Alcohol withdrawal
Mania -> bipolar affective disorder
Carbamazepine Metabolism
Plasma bound & slowly distributed

By liver microsomal enzymes -> produce microsomal enzyme induction (↓ t1/2 w/ chronic use) -> excreted in urine
Carbamazepine SE
Erythematous skin rash, agranulocytosis, aplastic anemia -> liver toxicity
Carbamazepine mnemonic
(Tegretol)
Carbs from EtOH in my Part Gin/Tonic gave me a headache (Trigem Neuralgia), made me a crazy red faced asian (SJS rash, test in Asians) w/ glasses (diplopia) eating bones and up and kill my liver (agranulocytosis & induce enzymes also kill liver)
Lamotrigine MOA
(Lamictal)
Na+ blocker
Lamotrigine mnemonic
Absence of Myo Sugar (glucuronidation) enzymes made me fall asleep on llama whose rough fur gave me a rash -> wake up with cross eyes & rash looking like zit-faced 16yo
Lamotrigine Indications
Partial seizures
Generalized tonic-clonic
Absence & Myoclonic
Lamotrigine SE
life-threatening dermatitis (llama's fur -> give rash)
DO NOT USE in pt <16 yo
NO enzyme induction
Ethosuximide MOA
(Zarontin)
T-type Ca inhibitor
"Ethos sux Val's Titty's of Milk until Absent"
(Inhibit low-threshold Ca currents (T-currents) in thalamic neurons
Absence seizures -> activation of T-type calcium channels in thalamus)
Valproic acid MOA
1) T-type Ca inhibitor
"Ethos sux Val's Titty's of Milk until Absent"
2) Inhibit T-type Ca channels
3) Increases Na channel inactivation
Prolong recovery of Na channel from inactivation -> ↓ Na influx
Ethosuximide Indications
(Zarontin)
Absence sz (DOC)
Valproic Acid MOA
1) Inhibits T-Type Ca2+ channels
2) Prolongs Na channel inactivation
3) Inhibits GABA transaminase -> increased GABA in brain
DOC for:
1) Pt w/ Absence & Gen. Tonic-Clonic
2) Myoclonic sz

Also tx: Absence, Manic (bipolar), Migraine
"Val was Absent minded 2yo c/o too many Gin/Tonic at MLB got a migraine so ate a steak even though not hungry -> got fat
Valproic acid mnemonic
"Val was Absent minded 2yo c/o too many Gin/Tonic at MLB got a migraine so ate a steak even though not hungry -> got fat & EtOH kills kids & liver
Ethosuximide mnemonic
(Zarontin)
Sucking -> agitation & bulemia (NVD) -> tired, no prot, bad skin, chained to H2O fountain for a long time
Ethosuximide SE
transient fatigue, lethargy, GASTRIC distress, SKIN reactions, AGITATION
Ethosuximide metab
long (40-50 hrs)
NOT protein bound
Hydroxylation & conjugation -> inactive metabolites
Gabapentin mnemonic
Fat & tired, can't walk, Says GAGA c/o CNS distress, drinks Part Gin/tonic for neuropathic pain but does not affect his liver
Pregabalin mnemonic
Pregaba has five bros named GABA (fibromyalgia)
Diazepam mnemonic
Diaz & Lora are acute epileptic couple (status epilepticus) who run
Diaz sprints
Lora marathons
Lorazepam mnemonic
Diaz & Lora are acute epileptic couple (status epilepticus) who run
Diaz sprints
Lora marathons
Clonazepam mnemonic
Clones are invincible, absent minded, absent tone, absent muscle, knocked out (absent consciousness)
Phenobarbital mnemonic
Barbi irritated/disturbed by feverish kids drank Part Gin/tonic to knock self out for 100 hours and up liver enzymes
Adjunct drugs mnemonic
I add partial clouds to LEVETATE to TOP of TAIGA ZONE
Topiramate mnemonic
Salty Gaba Kainite pirates drink Gin/Tonic to Kill migraine & Can't think or remember, lost wt c/o no protein in diet
Salty = Blocks Na, ups GABA inhib, decreases Kainite on AMPA-R
Tiagabine mnemonic
Tiger made me dizzy & nervous c/o wanted to eat me as protein so shot him w/ my one GAT
(GAT = Gat 1 isoform reuptake; inhibit -> increase GABA in brain)
Levetiracetam mnemonic
levetate in PART of my sleep for 6-8 hours
Zonisamide mnemonic
Kids go to hot zone get renal stones for PART of 60hrs
Felbamate mnemonic
Lenny feels up resistant parts of SoCal Girls who burn his bones & liver in reply
(SoCal Girls = Block Sodium, Calcium, Glycine co-activation of NMDA-R)
Anti-epileptics to monitor liver (liver processes)
Val Fel on a Tiger and hurt his liver, wasn't Phun
Anti-epileptics processed by kidney
Gaby's Pee reached the Top Level of her Kidney