Epilepsy is a chronic disorder with reoccurrence of unprovoked seizures that happens because of the electrical events that occur in the brain. An epileptic seiszure is a central nervous system disorder that affects neuron activity by causing an excessive amount of activity in the brain. This can be attributed to a large amount of action potentials that don’t allow for any relief, which can cause damage to the cell.
Antiepileptic drug therapy for epilepsy even though proven to give relief to many patients, causes patients tend to develop other conditions from epileptic seizures which then require the patient to take more medications. Also there are certain conditions in which the Antiepileptic drug is ineffective for many patients. Patients with epilepsy whose seizures do not successfully …show more content…
Patients with DRE have an increased mortality rate. “The standardized mortality ratio for patients with recurrent seizures is 4.69”. 2 Many studies have taken place to examine models of temporal lobe epilepsy. Studies with multiple implanted EEG electrodes at various brain regions, observed that response to epileptogenic drug /high stimulation was higher and faster at hippocampus than at other regions. Also tissue damage in the hippocampus is more visible.
Hence we focus our study in the factors affecting seizure activity in the hippocampus.
The first factor we are considering to model the hypothesis for testing is GABab receptors. γ-Aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the mammalian central nervous system. The GABA binds to two receptors, which are known as ionotropic and metabotropic g-protein coupled. The GABab is known for inducing potassium dependent hyperpoliariation, and it also affects voltage gated calcium currents. GABAB receptors are considered to play an important role in regulating brain network
Antiepileptic drug therapy for epilepsy even though proven to give relief to many patients, causes patients tend to develop other conditions from epileptic seizures which then require the patient to take more medications. Also there are certain conditions in which the Antiepileptic drug is ineffective for many patients. Patients with epilepsy whose seizures do not successfully …show more content…
Patients with DRE have an increased mortality rate. “The standardized mortality ratio for patients with recurrent seizures is 4.69”. 2 Many studies have taken place to examine models of temporal lobe epilepsy. Studies with multiple implanted EEG electrodes at various brain regions, observed that response to epileptogenic drug /high stimulation was higher and faster at hippocampus than at other regions. Also tissue damage in the hippocampus is more visible.
Hence we focus our study in the factors affecting seizure activity in the hippocampus.
The first factor we are considering to model the hypothesis for testing is GABab receptors. γ-Aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the mammalian central nervous system. The GABA binds to two receptors, which are known as ionotropic and metabotropic g-protein coupled. The GABab is known for inducing potassium dependent hyperpoliariation, and it also affects voltage gated calcium currents. GABAB receptors are considered to play an important role in regulating brain network