Anti Cancer Drugs

Front 1

when do these drugs work best?

Back 1

In G1 and S phase but CAN work outside of that.

Front 2

Mechanism of action of alkylating agents?

Back 2

drugs are electrophilic and they attack the N7 position on guanine resulting in DNA damage by inter/intra strand cross linking, abnormal base pairing, DNA strand breakage

Front 3

Resistance to alkylating agents?

Back 3

increased repari, decreased permeability to drug and increased production of thiol trapping agents

Front 4

Prototype of alkylating agents?

Back 4

cyclophosphamide

Front 5

toxicity of cyclophosphamide?

Back 5

GI, myelosuppression, alopecia, HEMORRHAGIC CYSTITIS from acrolein (helped with mesna). cardiac dysfunction and pulmonary toxicity, inappropriate ADH secretion

Front 6

What type of drug is mechorethane?

Back 6

DNA alkylating agents

Front 7

Toxicity of mechlorethane/

Back 7

same and secondary cancer due o to induction of mutations in healthy tissues

Front 8

what is special about nitrosoureas?

Back 8

very greasy can cross BBB and are used for brain tumors
they have high CNS toxicity

Front 9

What is the toxicity of platinum agent cisplatinum?

Back 9

cisplatinum has little bone marrow effect. GI distress, mild hematotoxicity, neurotoxicity, NEPHROTOXICITY - which can be reduced with forced hydration.

Front 10

toxicity of carboplatin?

Back 10

Less nephrotoxic than cis but cause myelosuppression and hearing loss