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10 Cards in this Set

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when do these drugs work best?
In G1 and S phase but CAN work outside of that.
Mechanism of action of alkylating agents?
drugs are electrophilic and they attack the N7 position on guanine resulting in DNA damage by inter/intra strand cross linking, abnormal base pairing, DNA strand breakage
Resistance to alkylating agents?
increased repari, decreased permeability to drug and increased production of thiol trapping agents
Prototype of alkylating agents?
cyclophosphamide
toxicity of cyclophosphamide?
GI, myelosuppression, alopecia, HEMORRHAGIC CYSTITIS from acrolein (helped with mesna). cardiac dysfunction and pulmonary toxicity, inappropriate ADH secretion
What type of drug is mechorethane?
DNA alkylating agents
Toxicity of mechlorethane/
same and secondary cancer due o to induction of mutations in healthy tissues
what is special about nitrosoureas?
very greasy can cross BBB and are used for brain tumors
they have high CNS toxicity
What is the toxicity of platinum agent cisplatinum?
cisplatinum has little bone marrow effect. GI distress, mild hematotoxicity, neurotoxicity, NEPHROTOXICITY - which can be reduced with forced hydration.
toxicity of carboplatin?
Less nephrotoxic than cis but cause myelosuppression and hearing loss