Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
21 Cards in this Set
- Front
- Back
|
alpha blockers (a1,a2)
|
PHENOXYBENZAMINE (a1 greater/ equal a2)
ALKALOIDS (from plants) (a1>>) |
|
|
indirect-acting antiadernertic
(ihibit cate syn) |
METYROSINE
|
|
|
a/b blocekrs
|
labetalol b1=b2>a1
|
|
|
b blockers
|
propranolol
pindolol timolol sotalol |
|
|
b1
|
metoprolol, acebutrolol, bisoprolol (good for stable heart failure)
atenolol esmolol |
|
|
a1
|
prazosin
tamsulosin |
|
|
two mechanisms
irreversible reversible |
irrs- PHENOXYBENZAMINE , covalent
revers - everything else |
|
|
a1 antag
|
prazosin/tamsulosin
HELPS WITH PROSTATE arterial/venous vasodilation EPI effect is REVERESED ADRENERGIC SWEATING STOPPED FALL IN BP! oral bio 60-90% distrubites all tissues (brain too) |
|
|
a1 - antag effects
|
Baroreceptors blocked when u stand up
Cardio - first dose hypotension (syncope), myocardial/cerebral ischemia perif EDeMA, w/ chronic treatment uninary freq/inconticance up sexual disfunction, inhibit ejact |
|
|
a1-antag uses
|
Pheochomocytoma (then u gotta use b blockers)
use in prostatic hypertrophy (rlx bladder) raynaur'ds disease (cold finger tips) chronic hypertension/emergency |
|
|
nonselctive a antag
(phenoxybenzamine) |
vaso dilation (perifer)
increase of HR (enchance NE release, reflex) EPi reversed HD - inhibtit cat reuptake (phenoxybenazmine) could last up to 7 days oral bio 30%, all tissues 24 hrs 1/2 life |
|
|
b antag
|
local anestheic (Na+) channels
affects are PRONOUNCED when symp tone is high/SMALL when tone is low ALL VASODILATION BLOCKED |
|
|
b antag
|
CVS - lower cardiac output
vessels - TPR inrease intially (reflex), normalizaed later resp - broncoconst nml...bad with ppl with ASTHMA) ocular - decreased rate of aq humor metabolism - decreased renin |
|
|
timolol
|
lower intra occ press
|
|
|
sotalol
|
pronounced K+ blocking actvity
|
|
|
a-b antag
|
labetol/carevediol
labetol - anesthetic activy cav - none decreased of TPR |
|
|
b antag
|
lipid SOLUBILTY!
prop,meto, labetoal low bioavail/big first pass/cross BBB |
|
|
b-antag adverse affects
|
CVS - perip vasc spams
heart failure, withrdrwal affects resp...= increase resistance sexual dysfunction (with chroinc treatments) |
|
|
contraindiactions
|
vascospaic angina - block b2, cause a1 vasoconstction
|
|
|
USES of b blockers
|
hypertension
arrhythimias exertional angina open/closed in glaucoma |
|
|
indirect acting
|
Metyrosinse - inhibit tyrosine hydroxylase (up to 70%)
|
