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94 Cards in this Set

  • Front
  • Back
which neurotransmitter is used by both sympathetic and parasympathetic ANS
ACH
mediates sympathetic control of some organ function
norepinephrine
what type of receptor is utilized by ACH at the ganglion
nicotinic
what type of receptor is utilized by ACH at the organ level
muscarinic
Norepinephrine and not ACH controls
metabolism (gluconeogenesis, glycogenolysis), Kidney (renin release), eye (increased aqueous humor production
ACH and not NE controls
secretion (lacrimation, salivation, sweating, GI secretions)
NE and ACH both control
Cardiac (force rate), smooth muscle (eye, vasculature, uterus, bronchioles, GI, GU)
two types of receptor motifs
ionotropic and metabotropic
ionotropic
ion channels nicotinic cholinergic receptors, mostly fast on off transduction
metabotropic
7 transmembrane g proteins, muscarinic cholinergic recptors. Pre and post synaptic
a2 think
pre synaptic
norepinphrine controls
adrenergic receptors
adrenergic receptors
alpha 1,2, beta 1,2
a1 is always
constrioction
b1
heart
b2
smooth muscle on lungs relaxation
ACH controls what receptors
cholinergic receptors
cholinergic receptors
nicotine and muscarinic
nicotinic receptors
ganglionic, NMJ
all b receptors produce
cAMP
cAMP activates
PKA
in smooth muscle PKA does what
inactivates MLCK
a2 found in what and do what
neurons, decrease cAMP production
M1, a1 activate what
Gq
Gq does what
activates Phospholipase C which cleaves a lipid signaling molecule PIP2 to IP3
muscarinics and a1 generally produce
contraction
2nd messenger m1,m3
gq, IP3 and DAG
2nd messenger m2
Gi, increased gK activation in heart, decreased cAMP
location of m1
nerves
location of m2
heart, nerves and SM
location of M3
glands, SM and endothelium
location Nm
NMJ
location Nn
ganglions, post synaptic neuron
a1 2nd messenger
gq IP3 and DAG
a2 2nd messenger
Gi decreased cAMP
a1 location
SM
a2 locaiton
presynaptic neurons most importantly
b1 location
cardiac cells, kidney
b2 location
SM, liver, skeletal muscle
autonomic receptor mnemonic
qissqiqaiqsqs, a1, a2, b1, b2, m1,m2,m3, d1,d2, h1,h2, v1,v2
mad 2
Gi, hate adenyl cyclase decrease cAMP and PKA
b1, b2, D1, H2, V2
Gs, AC- cAMP-PKA
H1, a1, M1, M3
Gq, PLC to pip2- IP3 increase Ca or PLC to pip2 to dag to PKC
how does the parasympathetic sys cause relaxation
indirectly via Muscarinic receptors which release NO
b2 cause what
activation of metabolism increase gluconeogenesis, glycogenolysis and lipid metabolism
b1 cause what and where
activation cardiac (increase force and rate), kidney increase renin release, eye increase aqueous humor production
B2 cause what and where
relaxation vasculature skeletal muscles, uterus, bronchioles, GI and GU walls
a1 cause what and where
contraction eye, vasculature , sphincters of GU and GI
explain NE and ACH control of cardiac fxn
NE B1 increase force and rate, ACH M2 decrease force and rate
NE does what does what to cardiac myocyte
B1 activation of Gs, increase cAMP and open calcium channel for depolarization
ACH does what to the heart
M2, Gi K+ out, hyperpolarization
a1 location
vasculature of organs, gut sphincters, eye radial muscle, GU sphincters
a1 fx
sympathetic effects, slows defecation, urination, widens pupils, shunts blood
a1 activates
gq, PLC IP3 and DAG activates MLCK
M3 location
gut walls, eye ciliary, circular, GU walls, bronchi
M3 fx
parasympathetic effects, defecation, urination, constricts pupils
b2 activate
Gs, cAMP PKA phosphorylate MLCK SM relaxation
muscarinic SM relaxation
NO diffuses GC to cGMP- PKG kinase and efflux of K+
iris contracts causes
pupil dilation
what receptor causes an increase in pupil diameter
a1
what receptor causes aqueous humor outflow and accomodation
M3
a2 in eye fx
inhibits NE release
b1 fx in eye
aqueous humor production
a2 fx in eye
mydriasis, open pupils radial muscle contraction
m3 fx in eye
ciliary muscle contraction (accomodation increase aquease humor outflow), circular muscle contraction (closes pupil)
b2 fx on skeletal muscle
activate by epinephrine increased sodium K atpase activity, redistributes ions factors.
sympathetic heart
b1
symp kidney
b1
para heart
m2
symp eye
b1 ciliary epithelium AH production
symp bronchiolar sm
relax b2
para bronchiolar sm
contracts M3
symp bladder walls
b2 relax
para bladder walls
m3 contract
symp uterus
b2 relax
symp liver
b2
symp skeletal and coronary vasculature
relax, decrease resistance b2
symp arterioles and veins
contract increase pressure a1
symp penis
contract ejaculation a1
para penis
m3 relax via NO release
symp bladder sphincter
contracts a1
para bladder sphincter
relaxes M3 via NO
symp GI sphincters
contracts a1
para GI sphincters
relaxes NO m3
eye radial dilator muscle
a1 contracts mydriasis
eye sphincter muscle
parasymp contracts M3
eye ciliary muscle
contracts near vision m3
glandular secretions symp
M increase sweat glands
glandular and gastric secretions para
M3 glandular M1 gastric
two main receptors that work on the hear
B1, M2
vascular resistance is controlled by
a1 which contract and b2 which dilate
a2 does what
decrease cAMP production in pre synaptic neurons which will result in less NE release
systolic bp is controlled by
b1 and m3 on the heart and a1 and b2 on the vasculature
diastolic bp is controlled by
a1 and b2 on the vasculature