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94 Cards in this Set
- Front
- Back
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which neurotransmitter is used by both sympathetic and parasympathetic ANS
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ACH
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mediates sympathetic control of some organ function
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norepinephrine
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what type of receptor is utilized by ACH at the ganglion
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nicotinic
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what type of receptor is utilized by ACH at the organ level
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muscarinic
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Norepinephrine and not ACH controls
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metabolism (gluconeogenesis, glycogenolysis), Kidney (renin release), eye (increased aqueous humor production
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ACH and not NE controls
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secretion (lacrimation, salivation, sweating, GI secretions)
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NE and ACH both control
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Cardiac (force rate), smooth muscle (eye, vasculature, uterus, bronchioles, GI, GU)
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two types of receptor motifs
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ionotropic and metabotropic
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ionotropic
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ion channels nicotinic cholinergic receptors, mostly fast on off transduction
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metabotropic
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7 transmembrane g proteins, muscarinic cholinergic recptors. Pre and post synaptic
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a2 think
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pre synaptic
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norepinphrine controls
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adrenergic receptors
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adrenergic receptors
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alpha 1,2, beta 1,2
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a1 is always
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constrioction
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b1
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heart
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b2
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smooth muscle on lungs relaxation
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ACH controls what receptors
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cholinergic receptors
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cholinergic receptors
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nicotine and muscarinic
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nicotinic receptors
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ganglionic, NMJ
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all b receptors produce
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cAMP
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cAMP activates
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PKA
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in smooth muscle PKA does what
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inactivates MLCK
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a2 found in what and do what
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neurons, decrease cAMP production
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M1, a1 activate what
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Gq
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Gq does what
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activates Phospholipase C which cleaves a lipid signaling molecule PIP2 to IP3
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muscarinics and a1 generally produce
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contraction
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2nd messenger m1,m3
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gq, IP3 and DAG
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2nd messenger m2
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Gi, increased gK activation in heart, decreased cAMP
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location of m1
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nerves
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location of m2
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heart, nerves and SM
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location of M3
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glands, SM and endothelium
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location Nm
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NMJ
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location Nn
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ganglions, post synaptic neuron
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a1 2nd messenger
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gq IP3 and DAG
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a2 2nd messenger
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Gi decreased cAMP
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a1 location
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SM
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a2 locaiton
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presynaptic neurons most importantly
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b1 location
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cardiac cells, kidney
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b2 location
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SM, liver, skeletal muscle
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autonomic receptor mnemonic
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qissqiqaiqsqs, a1, a2, b1, b2, m1,m2,m3, d1,d2, h1,h2, v1,v2
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mad 2
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Gi, hate adenyl cyclase decrease cAMP and PKA
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b1, b2, D1, H2, V2
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Gs, AC- cAMP-PKA
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H1, a1, M1, M3
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Gq, PLC to pip2- IP3 increase Ca or PLC to pip2 to dag to PKC
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how does the parasympathetic sys cause relaxation
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indirectly via Muscarinic receptors which release NO
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b2 cause what
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activation of metabolism increase gluconeogenesis, glycogenolysis and lipid metabolism
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b1 cause what and where
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activation cardiac (increase force and rate), kidney increase renin release, eye increase aqueous humor production
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B2 cause what and where
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relaxation vasculature skeletal muscles, uterus, bronchioles, GI and GU walls
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a1 cause what and where
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contraction eye, vasculature , sphincters of GU and GI
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explain NE and ACH control of cardiac fxn
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NE B1 increase force and rate, ACH M2 decrease force and rate
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NE does what does what to cardiac myocyte
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B1 activation of Gs, increase cAMP and open calcium channel for depolarization
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ACH does what to the heart
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M2, Gi K+ out, hyperpolarization
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a1 location
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vasculature of organs, gut sphincters, eye radial muscle, GU sphincters
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a1 fx
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sympathetic effects, slows defecation, urination, widens pupils, shunts blood
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a1 activates
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gq, PLC IP3 and DAG activates MLCK
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M3 location
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gut walls, eye ciliary, circular, GU walls, bronchi
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M3 fx
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parasympathetic effects, defecation, urination, constricts pupils
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b2 activate
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Gs, cAMP PKA phosphorylate MLCK SM relaxation
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muscarinic SM relaxation
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NO diffuses GC to cGMP- PKG kinase and efflux of K+
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iris contracts causes
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pupil dilation
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what receptor causes an increase in pupil diameter
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a1
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what receptor causes aqueous humor outflow and accomodation
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M3
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a2 in eye fx
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inhibits NE release
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b1 fx in eye
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aqueous humor production
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a2 fx in eye
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mydriasis, open pupils radial muscle contraction
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m3 fx in eye
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ciliary muscle contraction (accomodation increase aquease humor outflow), circular muscle contraction (closes pupil)
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b2 fx on skeletal muscle
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activate by epinephrine increased sodium K atpase activity, redistributes ions factors.
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sympathetic heart
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b1
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symp kidney
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b1
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para heart
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m2
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symp eye
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b1 ciliary epithelium AH production
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symp bronchiolar sm
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relax b2
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para bronchiolar sm
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contracts M3
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symp bladder walls
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b2 relax
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para bladder walls
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m3 contract
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symp uterus
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b2 relax
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symp liver
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b2
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symp skeletal and coronary vasculature
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relax, decrease resistance b2
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symp arterioles and veins
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contract increase pressure a1
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symp penis
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contract ejaculation a1
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para penis
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m3 relax via NO release
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symp bladder sphincter
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contracts a1
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para bladder sphincter
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relaxes M3 via NO
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symp GI sphincters
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contracts a1
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para GI sphincters
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relaxes NO m3
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eye radial dilator muscle
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a1 contracts mydriasis
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eye sphincter muscle
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parasymp contracts M3
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eye ciliary muscle
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contracts near vision m3
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glandular secretions symp
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M increase sweat glands
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glandular and gastric secretions para
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M3 glandular M1 gastric
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two main receptors that work on the hear
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B1, M2
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vascular resistance is controlled by
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a1 which contract and b2 which dilate
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a2 does what
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decrease cAMP production in pre synaptic neurons which will result in less NE release
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systolic bp is controlled by
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b1 and m3 on the heart and a1 and b2 on the vasculature
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diastolic bp is controlled by
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a1 and b2 on the vasculature
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