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89 Cards in this Set

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a drug which alleviates pain: ?
Analgesic
a drug which abolishes/blunts memory or events: ?
Amnestic
agent which induces sleep: ?
Hypnotic
the onset of the anesthetic: ?
Induction
the termination of an anesthetic, when the patient "wakes up": ?
Emergence
Nitrous Oxide: drug class
inhaled anasthetic
Nitrous Oxide: hypoxia?
no
Nitrous Oxide: rate of induction?
slow
Nitrous Oxide: respiratory depression
no
Nitrous Oxide: cardiac depression
no
Ether: drug class
inhaled anasthetic
Ether: hypoxia?
yes
Ether: rate of induction?
fast
Ether: respiratory depression
yes
Ether: cardiac depression
yes
Chloroform: : drug class
inhaled anasthetic
Chloroform: : cardiac depression
yes
Chloroform: : hepatic toxicity
yes
The Fluorinated Anesthetics: 3 from class
halothane, isoflurane, sevoflurane
Halothane : drug class
inhaled anasthetic
Halothane : chemistry
alkane
Halothane : hepatic toxicity
just a lil bit
Halothane : flammable
no
Isoflurane, : drug class
inhaled anasthetic
Isoflurane, : chemistry
ether
Isoflurane, : emergence rate
slow
Isoflurane, : cardiovascular efx
just a lil myocardial depresion; decreased systemic vascular resistance
Isoflurane, : respiratory efx
irritates airways; depression
Isoflurane, : hepatic efx
no hepatitis
Sevoflurane: : drug class
inhaled anasthetic
Sevoflurane: : chemistry
ether
Sevoflurane: : rate of induction?
fast
Sevoflurane: : emergence rate
fast
Sevoflurane: : blood solubility
low
MAC (minimum alveolar concentration): importance to anesthesia
expression of potency; concentration necessary at 1 atm that prevents movement in 50% subjects from pain
MAC-BAR: importance to anesthesia
concentration necessary to Block Adrenergic Response
Nitrous Oxide: blood solubility
stupid low
Nitrous Oxide: odor
none
Nitrous Oxide: cardiovascular efx
minimal depression; increased pulmonary artery pressure
Nitrous Oxide: respiratory efx
minimal depression
Nitrous Oxide: CNS circ efx
increased cerebral blood flow
Nitrous Oxide: hematopoietic sx
megaloblastic anemia is possible (supression of methionine sythetase)
Halothane : flammable
no
Halothane : blood solubility
moderate
Halothane : odor
sweet
Halothane : cardiovascular efx
slows heart rate, potentiates epinephrine induced arrythmias, myocardial depression
Halothane : respiratory efx
depression
Halothane : CNS circ efx
increased cerebral blood flow; decreased cerebral metabolism
Halothane : musculoskeletal
promotes relaxation; esp uterine
Halothane : hepatic efx
halothane hepatiis; 1:222K anesthetics
Halothane : renal efx
decreased GFR and renal flow
Malignant Hyperthermia: ?
potentially lethal condition associated with inhaled N2O and succinylcholine
Malignant Hyperthermia: tx
dantrolene (blocks Ca into muscles)
ryanodine receptor : ?
sarcoplasmic reticulul Ca channel; linked to malignant hyperthermia (anasthesia)
Barbituates: Cytochrome metabolism
P450
Barbituates: counterindx
porphyria
Barbituates: respiratory depression
yup
Barbituates: cardiac depression
yup (preserved baroreceptor reflex)
Pentobarbital : Cytochrome metabolism
P450
Pentobarbital : drug class
barbituate
Pentobarbital : counterindx
porphyria
Pentobarbital : respiratory depression
yup
Pentobarbital : cardiac depression
yup (preserved baroreceptor reflex)
Pentobarbital : elimination half life
12 hours
Pentobarbital : histamine release?
yes
Methohexital : drug class
barbituate
Methohexital : counterindx
porphyria
Methohexital : elimination half life
4 hours
Methohexital : histamine release?
no
Midazolam : Cytochrome metabolism
CYP 3A4
Midazolam : drug class
benzodiazapine
Midazolam : active metabolites
yes
Midazolam : interax
competes at CYP 3A4 w/ erythromn; -anil's
Diazepam: drug class
benzodiazapine
Diazepam: active metabolites
yes
Lorazepam: drug class
benzodiazapine
Lorazepam: active metabolites
no
Ketamine:: drug class
phencyclidines
Ketamine:: mechanism
NMDA receptor antagonist
Ketamine:: hepatic metabolism
yes
Ketamine:: intramuscular ok?
yup
Ketamine:: clinical use
battlefield; no resp depression; use when need spontaneous ventilation
Etomidate : chemistry
imidazole derivative
Etomidate : positive aspects
more rapid awakening than barbitutes; cardiovascular stability
Etomidate : drawbacks
nausea; decreased seizure threshold; adrenal supression; myoclonic movements
Etomidate : eliminatino route
hepatic
Etomidate : clinical use
when hemodynamic stability important
Propofol : hepatic metabolism
oh yeah
Propofol : clinical use
anesthesia for breif procedures