Anaesthetic induction: comparative effect of different drugs
The use of different drugs are often administered to different patients according to their conditions and needs. In a study, Dr Aypar (2007) and colleague investigated the comparative effects of sevoflurane and desflurane on QTc interval and cardiac rhythm during anaesthetic induction in children. The use of anaesthetic drugs may prolong the QTc interval of the ECG and this might also result in arrhythmias which may be fatal to the patient. In the study, the author recruited twenty children who are going to undergo inguinal hernia repair sugery, who do not have previous medical condition with normal QTc interval and no cardiac arrhythmias. Eleven of the patients were administered …show more content…
In the group who is administered with sevoflurane, there was no significant prolongation of the QTc interval. However, there is a significant prolongation of the QTc interval for the group who is administed with desflurane after five minutes and this persisted for another thirty minutes (Figure 12). The author also mentioned that there is no cardiac arrhythmias for the group that was administered with desflurane, only two patients in this group had a single ventricular extrasystole. In the group that was administered with sevoflurane, there was one patient that had a single, bigemini and multiform extrasystole. Figure 12: Mean QTc interval of the two groups of subjects (Aypar et al, 2007)
From this experiment we are able to see the correlation between the use of drug such as desflurane and the prolongation of QTc interval which is a prominent sign of abnormality in cardiac ECG. Hence, by monitoring such output produce by ECG we would be able to identify complication and possible life threatening cases during anaesthetic induction and operation procedure. Hence, using this information we would be able to evaluate the safety of the use of different drugs for anaesthetic
The use of different drugs are often administered to different patients according to their conditions and needs. In a study, Dr Aypar (2007) and colleague investigated the comparative effects of sevoflurane and desflurane on QTc interval and cardiac rhythm during anaesthetic induction in children. The use of anaesthetic drugs may prolong the QTc interval of the ECG and this might also result in arrhythmias which may be fatal to the patient. In the study, the author recruited twenty children who are going to undergo inguinal hernia repair sugery, who do not have previous medical condition with normal QTc interval and no cardiac arrhythmias. Eleven of the patients were administered …show more content…
In the group who is administered with sevoflurane, there was no significant prolongation of the QTc interval. However, there is a significant prolongation of the QTc interval for the group who is administed with desflurane after five minutes and this persisted for another thirty minutes (Figure 12). The author also mentioned that there is no cardiac arrhythmias for the group that was administered with desflurane, only two patients in this group had a single ventricular extrasystole. In the group that was administered with sevoflurane, there was one patient that had a single, bigemini and multiform extrasystole. Figure 12: Mean QTc interval of the two groups of subjects (Aypar et al, 2007)
From this experiment we are able to see the correlation between the use of drug such as desflurane and the prolongation of QTc interval which is a prominent sign of abnormality in cardiac ECG. Hence, by monitoring such output produce by ECG we would be able to identify complication and possible life threatening cases during anaesthetic induction and operation procedure. Hence, using this information we would be able to evaluate the safety of the use of different drugs for anaesthetic