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8 Cards in this Set
- Front
- Back
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what tends to be active, ionized or non-ionized portion of a drug
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non ionized, because lipid soluble
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are barbiturates acidic or alkaline
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acidic
so highly ionized in alkaline pH |
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are opioids acidic or basic
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basic
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are local anesthetics acidic or basic
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basic
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what do acidic drugs bind to
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albumin
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what do basic drugs bind to
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alpha 1 acid glycoprotein
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why do foetuses ion trap
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blood is more basic
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what is effect on volume of distribution of increasing water sollubility
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Vd is decreased and renal excretion increases
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