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22 Cards in this Set
- Front
- Back
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what does Ro stand for?
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rate of infusion
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what are the units of Ro?
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mg/min (mass/time)
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what does the C-T profile look like for IV infusion?
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plasma concentration increases until plateau achieved which is the steady state concentration CPSS
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what does CPSS stand for?
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steady state concentration
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what does the rate of drug entry equal?
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the rate of excretion
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illustrate Ro?
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Ro (mass/time) = CPSS (mass/volume) x ClB (volume/time)
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how can we calcualte clearance once steady state is reached?
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ClB = Ro/CPSS
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what does the steady state concentration depend on?
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only the infusion rate and systemic clearance
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what does the rate of infusion equal at steady state?
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rate of elimination
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illustrate Ro at steady state?
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Kel XSS
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what is XSS
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amount of drug in body at steady state
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what do you need to know to calculate the rate of infusion?
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clearance of drug and the plasma concentration needed at steady state
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illustrate the calculation for rate of infusion?
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CPSS = Ro/ClB = Ro/(Kel x Vd) = 1.44 x Ro x T(1/2)/Vd
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how can we calculate the number of half-lives needed to reach certain percentage of steady state?
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% stead state = 1- (1/2)^N where N is the infusion time/half life
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what is the time to reach steady state dependent on?
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solely on the elimination half-life of the drug
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how will increaseing dose affect the time to steady state?
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it won't, it will only increase the concentration at steady state
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what is the concentartion at steady state dependent on?
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rate of infusion and Vd
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what is a loading dose?
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an IV bolus before infusion
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what does a loading dose do?
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helps reach steady state more rapidly
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how doe a loading dose help reach steady state more rapidly?
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via the principle of superposition where the sun IV decay profile is added to the infusion profile
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illustrate calculating a loading dose?
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loading dose = Vd x CPSS
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illustrate calculating an infusion dose?
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Ro = ClB x CPSS = K x Vd x CPSS
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