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13 Cards in this Set
- Front
- Back
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What are Adrenergic neuron blockers?
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Drugs that disrupt the synthesis, storage, or release of NE
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What are the 2 adrenergic neuron blockers?
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-Guanethidine
-Reserpine |
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What is the main use of Guanethidine?
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Treatment of Essential hypertension
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How does Guanethidine get into adrenergic nerves?
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By NET (norepi transporter)
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What are 2 NET blockers? What would they do to Guanethidine?
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Cocaine and TCAs
-Block uptake of Guanethidine - so it wouldn't be able to work |
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What happens when Guanethidine is taken up into the adrenergic nerve?
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It depletes NE from granules
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Where are effects of Guanethidine seen and not seen?
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-Seen in peripheral nervous system only
-Not seen in the CNS |
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What are 3 major side effects of Guanethidine?
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-Diarrhea
-Orthostatic hypotension -Sexal dysfunction |
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How does Reserpine get into adrenergic nerves?
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By diffusion
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How does Reserpine deplete NE in nerves?
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By inhibiting VMAT2 so that dopamine can't get into storage vesicles
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Where are the effects of Reserpine seen? How?
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In the CNS and peripheral NS
-It is highly lipophilic |
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What has Reserpine been historically used to treat? Why isn't it anymore?
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-Hypertension
-It has depressive effects on the CNS so suicidal tendencies |
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So what are the 2 major side effects of Reserpine?
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-Suicide
-Diarrhea |
