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15 Cards in this Set
- Front
- Back
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5-HT info:
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Origin: Raphe nuclei
Receptors: 1-15, located all over body NORMAL SIDE EFFECTS: 5HT-2 agonists: sexual dysfunction, insomnia 5HT-3/4 agonists: Increased appetite, nausea, diarrhea RARE: Serotonin Syndrome: Agitation, tachycardia, hypertension, fever, hypervigilence, tremors. EPS, Akathisia (motor restlessness)...antipsychotic side-effects |
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What are the 4 DA pathways?
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Nigrostriatal - SNigra to BG. Motor movements...
SIDE EFFECTS: EPS, tardive dyskinesia MESOLIMBIC - VTA to Nu Acc...attention and pleasure. may be OVERACTIVE in schizo? MESOCORTICAL - VTA to PFC. Signal processing. HYPOACTIVE in schizo? Flattened affect. TUBEROINFUNDIBULAR - Prolactin Inhibition. Elevated prolatin = breast enlargement, lactation. |
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What are side-effects of D2 (dopamine) BLOCKADE?
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Side Effects: EPS (nigrostriatal), Flattened Affect (mesocortical), Slowed cognition (mesolimbic), increased prolactin (tuberoinfundibular)
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Norepinephrine Info:
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Originates: Locus Ceruleus
alpha-1 blockade EFFECTS: hypotension, drowsiness, dizziness, sexual dysfunction. |
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ACh Areas?
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Nucleus Basalis of Meynert: Learning, memory, Alzheimer's?
Striatal Interneurons: Oppose function of DA in motor functions Lateral Tegmental: Arousal Peripheral: Cardiac, GI, salivary, eyes, bladders. |
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ACh Side Effects?
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Anti-cholinergic Effects:
Dry mouth, constipation, decreased urination, blurry vision, thermodysregulation |
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Histamine info:
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From hypothalamus to Cortex, Limbic System, Thalamus
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Blockade of Histamine
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Side-effects: Sedation, weight gain, hypotension
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Why give patients different SSRIs?
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Some SSRI's have side-effects that are more activating (i.e. dopamine reuptake inh/noradrenergic reuptake inh) and some SSRI's are more sedating (anticholinergic, histamine effects)
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What are SASRI's?
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Serotonin Antagnosist Serotonin Reuptake Inhibitor. Block 5HT2 receptor, so less insomnia (more sedation) and fewer sexual side effects.
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What are the two classes of TCA's?
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selective NRI's and dual action SNRI's
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What effects do TCA's have?
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Anti-cholinergic, +/- anti-histaminic, antiadrenergic effects (hypotension, dizziness, drowsiness, sexual dysfxn), and ion channel blockers.
SNRI Dual action side effects: HTN, insomnia, constipation, sweating OD POTENTIAL! Pulseless Electrical Activity. |
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What are DRI's?
DRI side-effects |
Dopamine Reuptake Inhibitors (Wellbutrin)
Benefits? Smoking cessation, less weight gain, less sexual dysfunction SIDE EFFECTS? Seizure risks, insomnia, tremor, dry mouth/odd tastes |
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NSA Antidepressants?
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Noradrenergic Serotinergic ANTAGONIST: Blocks alpha-2 receptors on nerve terminals. Antagonist of 5HT2 and 5HT3 --> less sexual dysfunction, sedative, less diarrhea/nausea.
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What are MAOI's?
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MAO is the enzyme that breaks down the monoamines (5HT, DA, Norepi). MAO-A oxidizes 5HT and Norepi. MAO-B oxidizes DA.
Side effect for rapid removal off drug can lead to SEROTONIN SYNDROME. Other side effects include: Hypotension, insomnia, sexual dysfunction, CNS effects, constipation, dry mouth, weight gain, DEATH, SEIZURE |
