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15 Cards in this Set

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5-HT info:
Origin: Raphe nuclei
Receptors: 1-15, located all over body

NORMAL SIDE EFFECTS: 5HT-2 agonists: sexual dysfunction, insomnia 5HT-3/4 agonists: Increased appetite, nausea, diarrhea

RARE: Serotonin Syndrome: Agitation, tachycardia, hypertension, fever, hypervigilence, tremors. EPS, Akathisia (motor restlessness)...antipsychotic side-effects
What are the 4 DA pathways?
Nigrostriatal - SNigra to BG. Motor movements...

SIDE EFFECTS: EPS, tardive dyskinesia

MESOLIMBIC - VTA to Nu Acc...attention and pleasure. may be OVERACTIVE in schizo?

MESOCORTICAL - VTA to PFC. Signal processing. HYPOACTIVE in schizo? Flattened affect.

TUBEROINFUNDIBULAR - Prolactin Inhibition. Elevated prolatin = breast enlargement, lactation.
What are side-effects of D2 (dopamine) BLOCKADE?
Side Effects: EPS (nigrostriatal), Flattened Affect (mesocortical), Slowed cognition (mesolimbic), increased prolactin (tuberoinfundibular)
Norepinephrine Info:
Originates: Locus Ceruleus

alpha-1 blockade EFFECTS: hypotension, drowsiness, dizziness, sexual dysfunction.
ACh Areas?
Nucleus Basalis of Meynert: Learning, memory, Alzheimer's?

Striatal Interneurons: Oppose function of DA in motor functions

Lateral Tegmental: Arousal

Peripheral: Cardiac, GI, salivary, eyes, bladders.
ACh Side Effects?
Anti-cholinergic Effects:

Dry mouth, constipation, decreased urination, blurry vision, thermodysregulation
Histamine info:
From hypothalamus to Cortex, Limbic System, Thalamus
Blockade of Histamine
Side-effects: Sedation, weight gain, hypotension
Why give patients different SSRIs?
Some SSRI's have side-effects that are more activating (i.e. dopamine reuptake inh/noradrenergic reuptake inh) and some SSRI's are more sedating (anticholinergic, histamine effects)
What are SASRI's?
Serotonin Antagnosist Serotonin Reuptake Inhibitor. Block 5HT2 receptor, so less insomnia (more sedation) and fewer sexual side effects.
What are the two classes of TCA's?
selective NRI's and dual action SNRI's
What effects do TCA's have?
Anti-cholinergic, +/- anti-histaminic, antiadrenergic effects (hypotension, dizziness, drowsiness, sexual dysfxn), and ion channel blockers.

SNRI Dual action side effects: HTN, insomnia, constipation, sweating

OD POTENTIAL! Pulseless Electrical Activity.
What are DRI's?

DRI side-effects
Dopamine Reuptake Inhibitors (Wellbutrin)

Benefits? Smoking cessation, less weight gain, less sexual dysfunction

SIDE EFFECTS? Seizure risks, insomnia, tremor, dry mouth/odd tastes
NSA Antidepressants?
Noradrenergic Serotinergic ANTAGONIST: Blocks alpha-2 receptors on nerve terminals. Antagonist of 5HT2 and 5HT3 --> less sexual dysfunction, sedative, less diarrhea/nausea.
What are MAOI's?
MAO is the enzyme that breaks down the monoamines (5HT, DA, Norepi). MAO-A oxidizes 5HT and Norepi. MAO-B oxidizes DA.

Side effect for rapid removal off drug can lead to SEROTONIN SYNDROME.

Other side effects include: Hypotension, insomnia, sexual dysfunction, CNS effects, constipation, dry mouth, weight gain, DEATH, SEIZURE