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6 Cards in this Set
- Front
- Back
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Mechanisms
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1) inhibit cell wall synth.
2)disrupt membrane 3) inhibit protein synth (bacteriocidal v. bacteriostatic) 4)interferes w. DNA/RNA 5)antimetabolite |
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Resistance
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microbe will...
A)produce enzyme to metabolize it B)cease drug uptake c) alter receptor d) antagonist made by bug *its random -spontaneous: 1 drug -conjugation: multi-drug |
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Common resistant bugs
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MRSA (staph)
VRE (vanco resistant) MDR-TB suprainfections (thrush/yeast) |
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how to select an antibiotic
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1) ID org. - gram stain
2) sensitivity - Kirby Bauer, MIC (inhib. conc), MBC (bactericidal conc) 3) host factors/defenses - Emperic therapy until org ID'd |
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Do prophylactic antibiotics with...
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-bacterial endocarditis
-neutropenia -recurrent UTI -STD exposure |
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MISSUSES of antibiotics
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1) viral
2) fever of unknown cause 3) bad dose 4) surgical drainage **know pt allergies! |
