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6 Cards in this Set

  • Front
  • Back
Mechanisms
1) inhibit cell wall synth.
2)disrupt membrane
3) inhibit protein synth (bacteriocidal v. bacteriostatic)
4)interferes w. DNA/RNA
5)antimetabolite
Resistance
microbe will...
A)produce enzyme to metabolize it
B)cease drug uptake
c) alter receptor
d) antagonist made by bug
*its random
-spontaneous: 1 drug
-conjugation: multi-drug
Common resistant bugs
MRSA (staph)
VRE (vanco resistant)
MDR-TB
suprainfections (thrush/yeast)
how to select an antibiotic
1) ID org. - gram stain
2) sensitivity - Kirby Bauer, MIC (inhib. conc), MBC (bactericidal conc)
3) host factors/defenses
- Emperic therapy until org ID'd
Do prophylactic antibiotics with...
-bacterial endocarditis
-neutropenia
-recurrent UTI
-STD exposure
MISSUSES of antibiotics
1) viral
2) fever of unknown cause
3) bad dose
4) surgical drainage
**know pt allergies!