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17 Cards in this Set
- Front
- Back
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What is believed to be the cause of systemic lupus erythematosus? (SLE)
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Defective clearnce of apoptic bodies in combination with failure of self-tolerance leading to an abundance of anti-nuclear antioby complexes (ANAs) and proliferation of anti-nuclear IgG antibody production.
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What are some of the clinical features of SLE?
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Rather non-specific relapising fatigue, fever, and weight loss primarily affecting skin, joints, kidney and serosal membranes. Particulary prominent in women of childbearing age.
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What are the critary for diagnosing SLE?
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4 of 11 SLE classiifcation criteria including malar rash, discoid rash, photosensitivity, serositis, renal disorder, + ANA, etc.
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What is glomerulonephritis?
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The deposition of immune complexes in the glomeruli.
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What is the most common heart defect with SLE?
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pericarditis (also tends to affect primary mitral and aortic valves--endocarditis)
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What are some of the common laboratory tests for SLE?
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positive ANA, anti DNA and anti-Sm (Smith) presence
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What is a significant immunological disorder associated with lacrimal and salivary glands?
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Sjorgen syndrome (fibrous destruction of glands, lymphcytic infiltration),
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What are the most common clinical syndromes of Sjorgen syndrome?
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dry eyes and dry mouth
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What are some common immunological findings with Sjorgen syndrome?
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antibodies to SS-A (Ro) and SS-B (La)/riboproteins, rheumatoid factor, ANA +
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What is a common feature of systemic sclerosis?
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An excess of fibrous tissue in blood vessels and other tissues due to overactivation of effector T cells and other leukocytes, leading to cytokine production and ischemic injury that results in an increase in fibroblasts, and, ultimately, fibrosis.
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What syndrome is associated with systemic sclerosis?
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The CREST syndrome (calcinosis, Raynaud's phenomenon, esophoageal dysmotility, sclerodactyly, and telangiectasia)
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What are some common immunological laboratory findings?
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Anti Scl 70 (antibody to DNA topoisomerase), anti-centromere antibody, ANA+
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What disease lumps together the clinical features of SLE, systemic sclerosis and polymyositis?
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Mixed connective tissue disease
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What laboratory finding is consistent with mixed connective tissue disease?
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antibodies to U1 ribonuclear protein
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What does rheumatoid arthritis affect?
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joints and blood vessels
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What are some clinical features of rheumatoid arthritis?
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joint effusions, proliferative/inflammatory synovitis, ankylosis, rheumatoid nodules
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What are some laboratory findings associated with rheumatoid arthritis?
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rheumatoid factor (RF)--autoantibodies to Fc portion of IgG; anti-cyclic citrullinated peptide antibodies (anti CCP)--fairly specific for RA
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