Microbiology Recall: Autoimmune Disease

Front 1

What is an autoimmune disease?

Back 1

A disease caused by animmune raction against the body's own antigens and tissues

Front 2

What are four possible mechanisms of autoimmunity?

Back 2

1) Molecular mimicry
2) Alteration of normal proteins (via drugs)
3) Superantigens
4) Release of antigens from previously "privileged" sites (CNS, testes) by trauma

Front 3

What is molecular mimicry?

Back 3

Phenomenon where an environmental trigger resembles a component of the body resulting in an immune response directed against the environmental trigger that cross-reacts with that body component

Front 4

Which neoplasm are autoimmune diseases most commonly associated with?

Back 4

Thymomas

Front 5

What are the organ-specific autoimmune diseases that affect the thyroid gland?

Back 5

Graves disease
Hashimoto thyroiditis

Front 6

What are the organ-specific autoimmune diseases that affect the skin?

Back 6

Pemphigus vulgaris
Dermatitis herpetiformis
Autoimmune alopecia
Vitiligo

Front 7

What are the organ-specific autoimmune diseases that affect neurons?

Back 7

Multiple sclerosis
Guillan-Barre syndrome

Front 8

What are the organ-specific autoimmune diseases that affect the heart?

Back 8

Rheumatic fever

Front 9

What are the organ-specific autoimmune diseases that affect the kidney?

Back 9

Goodpastures

Front 10

What are the organ-specific autoimmune diseases that affect the stomach?

Back 10

Pernicious anemia

Front 11

What are the organ-specific autoimmune diseases that affect the pancreas?

Back 11

Type 1 diabetes mellitus

Front 12

What are the organ-specific autoimmune diseases that affect the adrenal gland?

Back 12

Autoimmune Addison disease

Front 13

What are the organ-specific autoimmune diseases that affect the RBCs?

Back 13

Autoimmune hemolytic anemia

Front 14

What are the organ-specific autoimmune diseases that affect the platelets?

Back 14

Idiopathic thrombocytopenic purpura

Front 15

What are the organ-specific autoimmune diseases that affect the muscle?

Back 15

Myasthenia gravis

Front 16

What are six systemic autoimmune diseases?

Back 16

1) SLE
2) Rheumatoid arthritis
3) Systemic necrotizing vasculitis
4) Wegener granulomatosis
5) Antiphospholipid syndrome
6) Sjogren syndrome

Front 17

Rheumatoid arthritis is associated with which human leukocyte antigen (HLA) type?

Back 17

HLA-DR4

Front 18

Systemic lupus erythematosus is associated with which HLA types?

Back 18

HLA-DR2
HLA-DR3

Front 19

Ankylosing spondylitis is associated wiht which HLA type?

Back 19

HLA-B27

Front 20

What autoimmune conditions are associated with HLA-B27?

Back 20

1) Psoriasis
2) Ankylosing spondylitis
3) Inflammatory bowel disease
4) Reiter syndrome

PAIR is an acronym for the autoimmune conditions associated wiht HLA-B27

Front 21

What disease is associated with antimicrosomal antibodies?

Back 21

Hashimoto's thyroiditis

Front 22

What disease is associated with antinuclear antibodies?

Back 22

SLE

Front 23

What disease is associated with anti-double-stranded DNA antibodies?

Back 23

SLE

Front 24

What disease is associated with anti-smith antibodies?

Back 24

SLE

Front 25

What disease is associated with antihistone antibodies?

Back 25

Drug induced SLE

Front 26

What disease is associated with anti-SS-B antibodies

Back 26

Sjogren syndrome

Front 27

What disease is associated with antiimmunoglobin G antibodies?

Back 27

Rheumatoid arthritis

Front 28

What disease is associated with anticentromere antibodies?

Back 28

Scleroderma (CREST syndrome)

Front 29

What disease is associated with antineutrophil antibodies?

Back 29

Vasculitis

Front 30

What disease is associated with anti-Scl-70 antibodies?

Back 30

Scleroderma (diffuse)

Front 31

What disease is associated with antiepithelial cell antibodies?

Back 31

Pemphigus vulgaris

Front 32

What disease is associated with antigliadin antibodies?

Back 32

Celiac disease

Front 33

What disease is associated with antimitochondrial antibodies?

Back 33

Primary biliary cirrhosis

Front 34

What disease is associated with antibasement membrane antibodies?

Back 34

Goodpastures disease

Front 35

What is the target of the immune response in Lambert-Eaton syndrome?

Back 35

Calcium channel receptor

Front 36

What is the target of the immune response in Myasthenia gravis?

Back 36

Acetylcholine receptor

Front 37

What is the target of the immune response in Graves disease?

Back 37

TSH receptor

Front 38

What is the target of the immune response in Hashimoto thyroiditis?

Back 38

Thyroid peroxidase and thyroglobulin

Front 39

What is the target of the immune response in Idiopathic thrombocytopenic purpura?

Back 39

Platelet glycoproteins IIb/IIIa

Front 40

What is the target of the immune response in pernicious anemia?

Back 40

Intrinsic factor and parietal cells

Front 41

What is the target of the immune response in Insulin-dependent diabetes mellitus?

Back 41

Pancreatic islet Beta cells

Front 42

What is the target of the immune response in Addison disease?

Back 42

Adrenal cortex

Front 43

What is the target of the immune response in Polyarteritis nodosa?

Back 43

Small and medium-size arteries

Front 44

What is the target of the immune response in Guillain-Barre syndrome?

Back 44

Myelin protein