Essay On Eczema

Although eczema research has progressed, the actual pathophysiology of eczema is reduced to two theories explaining why inflammation progresses to eczema. One theory describes immune dysregulation following immunoglobulin-E (IgE) sensitivity, causing weakness in the mucosal epithelial layer and allowing the development of eczema herpeticum and other infections to occur more easily. Studies have shown those who suffer from eczema, usually have a discrepancy in their T cells. Individuals with eczema also have prominent levels of T cells (Th17) when compared with individuals without the disease. People with mild eczema have an increase in the production of T cells (Th2), thus increasing the production of cytokines as well. Once cytokines production increases, plasma cells heighten the production of immunoglobulin-E (IgE), therefore, reducing the gamma levels. …show more content…
If interferon gamma levels are too low, viral resistance is low making the individual more vulnerable to developing infections; and if the body produces too many cytokines, this can also result in tissue damage weakening the body’s ability to defend pathogens. Individuals with more severe eczema have higher levels of T cells (Th1), as well as (Th2) cells. The significance of immunoglobulin-E (IgE) stimulates creation of mast and basophil cells. Mast and basophil cells are the effector cells, or the cells that respond to allergic diseases and bacterial infection. If immunoglobulin-E (IgE) is produced from damaged cytokines, the effectiveness of this antibody is stunted. The other theory is the altered skin barrier is due to deficiencies in skin layer and dry skin, which results from trans epidermal water