What I found most interesting about this module was how antibodies of the IgE isotype can bind to Fc receptors on the surface of mast cells. Although this effect most likely evolved as a component of protection against helminthic parasites, it continues to play a substantial role in symptoms for allergy. Mast cell activation is not further addressed until module 8.2, but understanding how mast cell activation plays a prominent role in the immune system is vital to learning how to combat potentially life-threatening allergic reactions.
In the course of my research, I came across an interesting link addressing the close relationship mast cells has with basophils & eosinophils. Although mast cells do not occur in the blood, their localization in areas such as the mucosa of the respiratory tract or digestive tract raise serious problems, as a result to their encounter with environmental or food allergens.
Along my research, I started noticing there were several papers addressing a specific allergic reaction, known as anaphylaxis. The severity of this allergic reaction is life-threatening and can occur almost immediately after exposure to something (stimuli) you may be allergic to. However, I wanted to seek other conditions that are far less appreciated or understood, such as asthma. …show more content…
A research team from Flinders University School of Medicine further elaborated on the role of mast cells & how they are activated by IgE receptor cross linking. Similar to anaphylaxis. However, in a person suffering from asthma, mast cell numbers are increased in the airway tissues and lead to recruitment & activation of Th2 lymphocytes (1). We learned that these type of helper cells play an important role in the adaptive immune system by releasing T cell cytokines, with intents of suppressing immune responses
In the course of my research, I came across an interesting link addressing the close relationship mast cells has with basophils & eosinophils. Although mast cells do not occur in the blood, their localization in areas such as the mucosa of the respiratory tract or digestive tract raise serious problems, as a result to their encounter with environmental or food allergens.
Along my research, I started noticing there were several papers addressing a specific allergic reaction, known as anaphylaxis. The severity of this allergic reaction is life-threatening and can occur almost immediately after exposure to something (stimuli) you may be allergic to. However, I wanted to seek other conditions that are far less appreciated or understood, such as asthma. …show more content…
A research team from Flinders University School of Medicine further elaborated on the role of mast cells & how they are activated by IgE receptor cross linking. Similar to anaphylaxis. However, in a person suffering from asthma, mast cell numbers are increased in the airway tissues and lead to recruitment & activation of Th2 lymphocytes (1). We learned that these type of helper cells play an important role in the adaptive immune system by releasing T cell cytokines, with intents of suppressing immune responses