Epidemiology Hemophilia is one of the most dangerous inherited bleeding disorders, affecting people from the entire world in equal frequency. Overall, the affected population frequency is low and the diagnosis of this disease is inherited about 70% of the time. Sometimes, hemophilia can occur when there is no family history of it and this is called sporadic hemophilia, having approximately 30% of people with non-inherited hemophilia, caused by a change in the person’s own genes (Blackwell 2012). According to Bolton-Maggs, there are different degrees of hemophilic disorders, having from lower risk cases to major and high risk diagnoses. In a research made in UK, scientists found that the disease is very rare in children,
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Hemophilia A can occur in all races and ethnic group and the incidence is approximately 1 case per 5000 males, with approximately one third of affected individuals without having a family history of the disorder. (Zaiden 2014) In the United States, the prevalence of hemophilia A is 20.6 cases per 100,000 males. In 2013, the number of people with hemophilia was estimated to be about 20,000. (Zaiden 2014). There’s a lower incidence of this disease when compared to another country where consanguineous marriage is …show more content…
2014). In the case of inheritance, the defective gene that causes hemophilia A is only carried on X chromosomes, never on Y chromosomes. Therefore, it is often carried by females but expressed by males. This is because females inherit two X chromosomes, one from their mother and one from their father. If one of the X chromosomes that a female inherits is flawed (carrying the defective gene) her other healthy X chromosome will allow her body to make sufficient clotting factors. However, males inherit one X chromosome from their mother, and one Y chromosome from their father. If a boy inherits a flawed X chromosome from his mother, he will develop hemophilia (Lewis 2011). A spontaneous genetic mutation may cause hemophilia if the gene that regulates clotting factors is altered. A spontaneous genetic mutation can happen in a person with no family history of the disease. These instances account for about thirty percent of all hemophilia cases (Hemophilia Federation of America
Hemophilia A can occur in all races and ethnic group and the incidence is approximately 1 case per 5000 males, with approximately one third of affected individuals without having a family history of the disorder. (Zaiden 2014) In the United States, the prevalence of hemophilia A is 20.6 cases per 100,000 males. In 2013, the number of people with hemophilia was estimated to be about 20,000. (Zaiden 2014). There’s a lower incidence of this disease when compared to another country where consanguineous marriage is …show more content…
2014). In the case of inheritance, the defective gene that causes hemophilia A is only carried on X chromosomes, never on Y chromosomes. Therefore, it is often carried by females but expressed by males. This is because females inherit two X chromosomes, one from their mother and one from their father. If one of the X chromosomes that a female inherits is flawed (carrying the defective gene) her other healthy X chromosome will allow her body to make sufficient clotting factors. However, males inherit one X chromosome from their mother, and one Y chromosome from their father. If a boy inherits a flawed X chromosome from his mother, he will develop hemophilia (Lewis 2011). A spontaneous genetic mutation may cause hemophilia if the gene that regulates clotting factors is altered. A spontaneous genetic mutation can happen in a person with no family history of the disease. These instances account for about thirty percent of all hemophilia cases (Hemophilia Federation of America