The Marfan Syndrome

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Marfan syndrome (MFS) is an autosomal dominant inherited connective tissue disorder with the main manifestations in the skeletal (overgrowth), ocular (ectopia lentis), and cardiovascular system(1) . The disease has an estimated worldwide prevalence between 1/3000 and 1/5000, irrespective of gender or ethnicity(1). Dietz and colleagues determined that mutations in the FBN1 gene on chromosome 15 is the cause of the disease(1). Therefore, it is of great significance to understand the clinical diagnosis, complications and management of this disorder since it will lead to a decrease in mortality rate and facilitate the expansion of the lives of many

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