Amyloid

aged and elderly” (Nordberg, 2001). To this day, there is no known cure for AD, regardless of its high prevalence among the elderly. AD is a neurodegenerative disease known to cause cerebral atrophy, tau pathology (neurofibrillary tangles) and β-amyloid plaques (Buckner et al., 2005). Through the use of positron emission tomography (PET), researchers have been able to observe a loss of nicotinic acetylcholine receptors (nAChRs) early on in the progression of the disease (Okada et…

in western countries. AL amyloidosis is usually a systemic disease, characterized by these fibril proteins depositing into multiple organs. Renal manifestations are the most frequent, affecting two-thirds of patients at the time of diagnosis. Amyloid proteins can deposit in the kidney and cause a range of issues from heavy proteinuria to nephrotic syndrome and impaired renal…

The disease that was chosen for me this time was Amyloidosis. The cause of this disease on your body is there is a buildup of amyloid (abnormal protein that is usually produced in your bone marrow and then can go to any organ or tissue) in your organs. This disease is classified as pretty rare and incurable. There are a variety of characteristics that show up depending on what part of your body the disease is affecting. Symptoms show up when the disease has advanced. Some of these include severe…

throughout life, their aggregates gradually accumulate as we age. These aggregates form distinct and observable structures in the brain which generally known as amyloid deposits in the brain. Furthermore, some form of mutation increase the chance of misfolding in proteins which is the case in the genetic or familial case of NDs [22]. Though the mechanism is not clear, it has been proven that deposits of misfolded proteins are known to be neurotoxic and able to cause apoptosis in neuronal cells.…

The protein that has been most focused on in recent years is the Beta-amyloid proteins. These are cerebral plaques that are found in neocortical terminal fields. Beta-amyloids create a loss of neurons and white matter in the brain with inflammation and oxidative damage present as well (Querfuth & LaFerla, 2010). The A-Beta peptides are consisted of 36 to 40 amino acids that are natural products of metabolism. The Beta-amyloid peptides are derived from an imbalance of aggregation of peptides that…

disturbance in NO pathways (29, 30). Peroxisome proliferator activated receptors (PPARs) signaling is also affected. PPARs are shown to reduce inflammatory response in macrophages. The neuroinflammatory response of AD is activated by installation of the β-amyloid peptide in extracellular…

Alzheimer's disease was named after Dr. Alois Alzheimer; however, Dr. Alois Alzheimer was not the only person to contribute to the discovery of the neurological disease, Alzheimer's. According to Dennis J. Selkoe in "Amyloid Protein and Alzheimer's Disease," he states, "Even before the time of Alzheimer, pathologists knew that the human cerebral cortex sometimes contained variable numbers of spherical plaques" (252-253). So, the question is, what did Dr. Alois Alzheimer contribute to the…

When Genova uses scientific terms, she first explains the term with the use of pictures. She also uses analogies which works with the pictures to deepen the audience’s understanding. In the video, Genova says, “think of amyloid plaques as a lit match. At the tipping point, the match sets fire to the forest. Once the forest is ablaze, it doesn’t do any good to blow out the match. You have to blow out the match before the forest catches fire” (2017). This analogy deepens the…

genes are used for cell growth and maturation.The protein makes sure that the cells are growing properly and that they are maturing properly as well. Presenilin is also known for its role in processing amyloid precursor protein which is located in the brain and the brain tissue (PSEN1 gene ). Amyloid precursor is a protein that is in tissues and concentrates on the synapse area of the brain (PSEN1 gene ). Another role that presenilin has is that it helps to cut down protein into smaller…

is abnormal accumulation and deposition of proteins in certain disease states causing malfunction in certain cells (Walker and LeVine 2000 p 83). The amyloid beta and amyloid tau protein are the proteins associated with affecting an Alzheimer’s brain. The most distinctive marker of Alzheimer’s is neurofillary tangles which are aggregates of amyloid tau proteins found in the brain (Kaur et al 2012 p 161). It is the most common characteristic neuropathic lesion and essential for neuropathological…