According to the seventh edition pathophysiology text, "Pathophysiology is one of the most important bridging sciences between preclinical and clinical courses for students in the health sciences and it requires in-depth study at an early stage in the curriculum.” (McCance and Huether 2014) To understand pathophysiology is crucial in medicine and for those entering health science related careers. As McCance and Huether explain, Pathophysiology opens many doors for numerous people, illnesses, and potential cures and treatments. Mastering the course of physiology and understanding how the body functions in a healthy state is a feat on its own, but it is even greater to understand the body when things start having complications or fail. For numerous
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The protein that has been most focused on in recent years is the Beta-amyloid proteins. These are cerebral plaques that are found in neocortical terminal fields. Beta-amyloids create a loss of neurons and white matter in the brain with inflammation and oxidative damage present as well (Querfuth & LaFerla, 2010). The A-Beta peptides are consisted of 36 to 40 amino acids that are natural products of metabolism. The Beta-amyloid peptides are derived from an imbalance of aggregation of peptides that causes A-Beta to accumulate which in return initiates the start of Alzheimer’s disease. The process of how Beta-amyloids may affect and or have a role in the beginning of Alzheimer’s is called the amyloid hypothesis. (Querfuth & LaFerla, 2010) There are many other theories to why Alzheimer’s occurs and what happens physiologically in the brain, but there is still so much that is unknown and yet to be …show more content…
The progression and persistence research has made in regards to Alzheimer’s, with theories of potential causes and treatments, demonstrates why pathophysiology is so fundamental when studying illnesses and diseases in this day and age. It would be almost impossible for past scientists to be able to make the leaps that we are making today in healthcare and research fields. We are closer to future disease preventions today than ever before, but it will take a lot of tedious work and a strong understanding of pathophysiological complications related to the diseases being
The protein that has been most focused on in recent years is the Beta-amyloid proteins. These are cerebral plaques that are found in neocortical terminal fields. Beta-amyloids create a loss of neurons and white matter in the brain with inflammation and oxidative damage present as well (Querfuth & LaFerla, 2010). The A-Beta peptides are consisted of 36 to 40 amino acids that are natural products of metabolism. The Beta-amyloid peptides are derived from an imbalance of aggregation of peptides that causes A-Beta to accumulate which in return initiates the start of Alzheimer’s disease. The process of how Beta-amyloids may affect and or have a role in the beginning of Alzheimer’s is called the amyloid hypothesis. (Querfuth & LaFerla, 2010) There are many other theories to why Alzheimer’s occurs and what happens physiologically in the brain, but there is still so much that is unknown and yet to be …show more content…
The progression and persistence research has made in regards to Alzheimer’s, with theories of potential causes and treatments, demonstrates why pathophysiology is so fundamental when studying illnesses and diseases in this day and age. It would be almost impossible for past scientists to be able to make the leaps that we are making today in healthcare and research fields. We are closer to future disease preventions today than ever before, but it will take a lot of tedious work and a strong understanding of pathophysiological complications related to the diseases being