Y2S2B3 - Cs - Last Exam Ever

Front 1

1st line tx of Status Epilepticus?

Back 1

Lorazepam

2nd line?

Hint 1

Phenytoin

Front 2

Birth control doesn't work well with what seizure med?

Back 2

Carbamazepine

What is the major SE to watch out for with this drug?

Hint 2

hypOnatremia

This is the only SE that is worse with oxcarbazepine!

Front 3

DOC for Benign Essential Tremor?

Back 3

Pheno, Pento, Primidone

Front 4

Which AED causes weight LOSS, renal stones, & angle closure glaucoma?

Back 4

Topiramate

must be titrated slowly over 2 mos

Front 5

AED of choice for women looking to get pregnant?

Back 5

Lamotrigine

Front 6

Which AEDs are known for interacting with Warfarin?

Back 6

Phenytoin & Valproate

Front 7

Which AED can cause pancreatitis?

Back 7

Valproate

Front 8

What drugs are short-acting and good for use after treatment-associated depression?

Back 8

Pschostimulants (Methyphenidate, Dextroamphetamine)

Cocaine in combo with morphine used to be used to treat depression

Front 9

Drug to lower LDL?

Raise HDL?

Back 9

statin, Niacin

Drug to lower TG's?

Hint 9

Fibrate

Front 10

Medical Tx of asymptomatic carotid stenosis?

Back 10

Dual antiplatelet Tx. (asa & clopidogrel)

Front 11

Prophylaxis for contacts of meningococcal meningitis?

Back 11

Rifampin

Front 12

Tx of cysticercosis?

Back 12

Praziquantel

Front 13

Tx of toxoplasma gondii?

Back 13

Pyrimethamine and Sulfadiazine

Front 14

Intermediate, large B cell, non-Hodgkin lymphoma tx?

Back 14

CHOP/Rituxin

Front 15

Reed Sternberg cells hallmark for what?

Back 15

Hodgkin Lymphoma

Front 16

Drugs used for growth factor support?

Back 16

Neulasta, G-CSF, GM-CSF

What is a notable SE of Neulastra?

Hint 16

Bone pain

Front 17

Possible meds for myelodysplastic syndromes?

Back 17

Growth factors
Methylating agents
Vidaza
Dicitibine
Revlimid

Revlimid is used for what?

Hint 17

5Q syndrome

Front 18

What are 2 hypomethylating agents?

Back 18

Decitibine (more potent), Azacytidine

Front 19

Auer rod body pathognomonic for what?

Back 19

AML

Front 20

Favorable prognostic chromosomal abnormalities in AML?

Back 20

T(8;21), Inv (16), T(15,17)

Poor prognostic cytogenetics?

Hint 20

Del (5q), Del (7q)

Front 21

Classic chromosome translocation for Promyelocytic Leukemia?

Back 21

T(15,17)

also Pml-rar, RT-PCR

Front 22

Tx of Acute Promyelocytic Leukemia?

Back 22

It presents w/ DIC! tx: retinoic acid & maybe heparin

Front 23

Induction therapy of AML other than promyelocytic?

Back 23

Cytarabine + Anthracycline (7 days + 3 days)
Mitoxantrone
Etoposide

Check ejection fraction first!
Newer tx's include anti-CD33 drugs or hypomethylating agents.

Front 24

MC etiology of seizure in...
a) 0-14 yo
b) 15-35 yo
c) 35-64 yo
d) >65 yo

Back 24

a) Congenital
b) Head trauma
c) Vascular
d) Vascular then degenerative

Front 25

Brain tumor in child w/ NF type 1, rosenthal fibers, cyst w/ enhancing mural nodule, 90% 10-yr survival w/ resection?

Back 25

Pilocytic astrocytoma

Front 26

Brain tumor a/w tuberous sclerosis, "ash leaf" spots on skin, can obstruct foramen of monroe, has giant astrocytes, benign but can recur?

Back 26

Subependymal Giant Cell astrocytoma

Front 27

brain tumor w/ seizure in 15 yo in temporal lobe, superficial meningo-cerebral nodule w/ a cyst, good prognosis w/ resection?

Back 27

Pleomorphic xanthroastrocytoma

Front 28

brain tumor in 40 yo male w/ seizure, NOT enhancing on MRI, hypercellular, often no tx?

Back 28

low-grade astrocytoma

if there were nuclear atypia?

Hint 28

Anaplastic astrocytoma

Front 29

brain tumor in 50 yo male, w/ seizure, in frontal & temporal lobes crossing corpus callosum. central necrosis & vasogenic edema

Back 29

Glioblastoma multiforme

Front 30

brain tumor: age 30-50, seizures, frontal & temporal, calcification, "fried egg" cells

Back 30

Oligodendroglioma

Front 31

tumor usu in 4th ventricle, age 10-15 yo?

Back 31

Ependymoma

Front 32

MC peds posterior fossa tumor, midline w/ "drop mets," Homer-Wright Rosettes

Back 32

Medulloblastoma

Front 33

neuro tumor w/ myoclonus-opsoclonus, sympathetic chain involved, calcified lesions, usu <5 yo?

Back 33

Neuroblastoma

Front 34

neuro tumor w/ Parinaud’s syndrome. Will get upgaze paralysis, conv-retract nystagmus ; light near dissociation, hydrocephalus, "drop mets"

Back 34

Pineoblastoma

Front 35

Bilateral acoustic neuromas... think =

Back 35

NF 2

Antoni A & Antoni B fibers?

Hint 35

Schwannoma

Front 36

neuro tumor that erodes the pedicles?

Back 36

Neurofibroma

Front 37

psamomma bodies w/ which neuro tumor?

Back 37

Meningioma

Front 38

Central neurocytomas are located where?

Back 38

in the ventricle

Front 39

MC child supratentorial tumor?

Back 39

Craniopharyngioma

MC infratentorial?

Hint 39

medulloblastoma

Front 40

MC pineal region tumor?

Back 40

Germinoma

Front 41

Papillomas/carcinomas of the choroid plexus are MC where in adults? in kids?

Back 41

adults - 4th ventricle
kids - lateral ventricles

Front 42

Neuro mass that can cause "drop attacks" when you lean forward d/t blocking foramen of monroe?

Back 42

Colloid cyst, benign in 3rd ventricle

Front 43

MC posterior fossa tumor in adults?

Back 43

Hemangioblastoma

it's a/w what disorder?

Hint 43

Von-Hippel Lindau dz

Front 44

1 ring enhancing lesion in brain of immunosuppressed pt. most likely is?

Back 44

Primary CNS Lymphoma

Usually B cell

Front 45

Tx of vasogenic edema in brain d/t brain tumor, affecting the white matter?

Back 45

Decadron

Front 46

What brain herniation can cause an ACA stroke?

Back 46

cingulate (goes under falx)

Front 47

Blown pupils (3rd nerve palsy) w/ hemiparesis. suspect what type of herniation?

Back 47

uncal

Front 48

a) Rosenthal fibers—
b) “Fried egg”—
c) Homer-Wright—
d) Antoni A & B—
e) Psammoma—
f) Lafora body—
g) NF tangles—
h) Cowdry A—
i) Cowdry B–
j) Negri bodies—

Back 48

a) pilocytic atrocytoma
b) oligodendroglioma
c) medulloblastoma
d) schwannoma
e) meningioma
f) myoclonic epilepsy
g) Alzheimer’s
h) viral infx
i) acute polio
j) Rabies

Front 49

Pharm tx of delirium d/t cancer tx?

Back 49

Anti-psychotic meds:
Haloperidol – most studied drug
Risperdal
Olanzapine

Sedatives:
Benzodiazepams (Avoid use except in specific clinical situations, Benzo’s are generally the wrong medication to give)

Front 50

Tx's a/w an increased risk of depression in cancer pts?

Back 50

Steroids
Interferon/interleukin
Procarbazine
L-Asparaginase

Front 51

What drugs can be used for quick relief of depression?

Back 51

Psychostimulants: Methyphenidate, Dextroamphetamine

Front 52

Cancer patients with abdominal ascites, edema, abdominal distention and a tender liver are at increased risk for bowel obstruction and may benefit from what type of pain med?

Back 52

fentanyl patch.*

Front 53

Neuropathic pain is particularly common in what?

Back 53

breast cancer with the use of paclitaxel (microtubule poison and causes neuropathy which could be disabling)

Other agents known to cause neuropathic pain are vincristine, bortezomib (could also cause neuropathy in some pts), and platinum based agents.

Front 54

There is no standard of care for neuropathic pain syndrome but what are some options?*

Back 54

nortriptyline, lamotrigine, duloxetine, and gabapentin

Front 55

Tx of hypercalcemia in cancer pt?

Back 55

Normal saline, bisphosphonates, gallium nitrate, calcitonin, plicamycin, dialysis

Front 56

Tx of hyperleukocytosis w/ leukostasis?

Back 56

• Hydroxyurea 2-5 grams po
• Hold PRBC transfusions
• Leukopheresis
• Induction chemotherapy

Front 57

Neisseria meningitis vaccine covers what serogroups?

Back 57

A, C, Y, W135

Front 58

Tx of bacterial meningitis:

a) <1 mo
b) 1 mo - 50 yo
c) >50 yo
d) post head tx, post neurosx, shunt in place

Back 58

a) Ampicillin + cefotaxime
b) Vanco + (Ceftriaxone or cefotaxime)
c) Vanco + (Ceftriaxone or cefotaxime) + Ampicillin
d) Vanco + (Cefepime or Ceftazidime)

Also, dexamethasone may be given w/ 1st dose & w/ strep pneumo

Front 59

How long do you treat each meningitis?


a) N. meningitidis -
b) S. pneumoniae –
c) H. influenza -
d) L. monocytogenes –
e) Gram negative bacilli –

Back 59

a) Treat for 4 – 7 days after afebrile
b) Treat for 10 -14 days
c) Treat for 7-10 days
d&e) Treat for 21 days

Front 60

Lyme dz meds

a) tick bite prophlaxis
b) early tx
c) bells palsy alone
d) other neuro manifestations
e) mild carditis
f) late lyme arthritis

Back 60

a) doxycycline w/in 72 hrs
b) doxycycline 10-21 days or amoxicillin 14-21 days
c) oral doxy or amoxi
d) ceftriaxone IV for 10-28 days
e) oral doxi or amoxi
f) doxy or amoxi for 1-2 mos

Front 61

Common brain abscess pathogens a/w Dental Abscess

Back 61

Streptococci, Bacteroides

Front 62

Common brain abscess pathogens a/w Chronic Otitis –

Back 62

Bacteroides, Pseudomonas, Proteus

Front 63

Common brain abscess pathogens a/w Sinusitis –

Back 63

Streptococci, Haemophilus

Front 64

Common brain abscess pathogens a/w Penetrating Trauma or Post Surgical –

Back 64

Staphylococcus, Pseudomonas

Front 65

Common brain abscess pathogens a/w Bacterial Endocarditis –

Back 65

Mixed flora

Front 66

Common brain abscess pathogens a/w Congenital Heart Disease –

Back 66

Streptococci

Front 67

Common brain abscess pathogens a/w Pulmonary Infection –

Back 67

Nocardia, Bacteroides

Front 68

Common brain abscess pathogens a/w HIV infection –

Back 68

Toxoplasma gondii