Wsu Som Unit 3 Pogue Gi/gu

Front 1

Most common anaerobes in normal enteric flora?

Back 1

Bacteroides, Clostridium, peptostreptococci

Front 2

Most common aerobes in normal enteric flora?

Back 2

E. coli, Proteus, Klebsiella

Front 3

Most resistant anaerobe?

Back 3

B. fragilis

Front 4

E. coli sensitivities?

Back 4

Vary greatly from location to location

Front 5

Most common bugs in community acquired GI infections?

Back 5

EPK, anaerobes

Front 6

Most common bugs in hospital acquired GI infections?

Back 6

Pseudomonas, enterococcus, candida

Front 7

Most common organisms for SBP?

Back 7

E. coli, streptococcus, Klebsiella

Front 8

SBP treatment?

Back 8

3rd generation cephalosporins, 5-7 days

Front 9

Should acute cholecystitis always be treated with antibiotics?

Back 9

No, only if infection is suspected (usually inflammatory)

Front 10

Primary treatment for infectious diarrhea?

Back 10

Rehydration therapy

Front 11

For what organisms is antimicrobial therapy for infectious diarrhea appropriate?

Back 11

Shigella, campylobacter, C diff

Front 12

For which infections should anti-motility agents be avoided?

Back 12

Shiga-toxin producing E. coli, C diff

Front 13

Is antibiotic therapy for Salmonella recommended?

Back 13

No, unless severe

Front 14

Possible treatment options for Salmonella?

Back 14

Ciprofloxacin, ampicillin/amoxicillin

Front 15

Duration of therapy for Salmonella?

Back 15

5-7 days, or 14+ for immunocompromised

Front 16

Duration of therapy for Shigella?

Back 16

3-5 days, 7-10 for immunocompromised

Front 17

Duration of therapy for E. coli and Aeromonas?

Back 17

3 days

Front 18

Treatment for vibrio cholera?

Back 18

Single high dose doxycycline

Front 19

Treatment for Giardia?

Back 19

Metronidazole 7-10 days

Front 20

General treatment for traveler's diarrhea?

Back 20

Fluoroquinolones

Front 21

When shouldn't fluoroquinolones be used for traveler's diarrhea?

Back 21

Giardia (metronidazole) and vibrio cholera (doxycycline)

Front 22

First line therapy for mild-moderate C. diff?

Back 22

Metronidazole (oral)

Front 23

Fist line therapy for severe C. diff?

Back 23

Vancomycin (oral)

Front 24

Why are oral formulations given for C. diff treatment?

Back 24

Better fecal concentrations

Front 25

Unique about Fidoxamicin, new C. diff treatment?

Back 25

Binds RNA pol to inhibit RNA synthesis, bactericidal

Front 26

Hepatitis C treatment?

Back 26

IFNalpha + ribavirin

Front 27

MOA of ribavirin?

Back 27

Mimics guanine to inhibit RNA synthesis

Front 28

Side effects of ribavirin?

Back 28

Hemolytic anemia

Front 29

Advantage/disadvantage of adding HCV protease inhibitors?

Back 29

Increase acute toxicity, but decrease overall duration of therapy

Front 30

Major drug integration with HCV PI boceprevir?

Back 30

CYP3A4/5 inhibitor and substrate

Front 31

Major cause of cystitis?

Back 31

E. coli

Front 32

Inhibits enolpyruvate transferase for gram negative bactericidal treatment in lower UTI?

Back 32

Fosfomycin

Front 33

Oral treatment of uncomplicated pyelonephritis?

Back 33

FQs, 3rd generation cephs, or TMP/SMX; 7-10 days

Front 34

Not appropriate for pyelonephritis treatment?

Back 34

Nitrofurantoin

Front 35

Is vanco an apporpriate treatment for healthcare associated UTI?

Back 35

No, no need for MRSA coverage

Front 36

When should asymptomatic bacteremia be treated?

Back 36

Pregnancy, neonates, surgery, or renal transplant

Front 37

Treatment of chancroid, and should this include sexual partners?

Back 37

Single high dose azithromycin, yes

Front 38

Treatment of first episode of HSV?

Back 38

(Val)acyclovir, 7-10 days

Front 39

Treatment of recurrent HSV?

Back 39

Daily valacyclovir

Front 40

Treatment for syphilis?

Back 40

Benzathine penicillin

Front 41

Syphilis treatment if patient is allergic to penicillins?

Back 41

Doxycycline or ceftriaxone

Front 42

Treatment if patient has progressed to neurosyphilis?

Back 42

Max dose penicillin IV

Front 43

Reaction soon after syphilis treatment?

Back 43

Jarisch-Herxheimer, causes headache, fever, myalgias, tachycardia

Front 44

Treatment for chlamydia?

Back 44

Azithromycin single dose

Front 45

Treatment of uncomplicated N. gonorrhoeae?

Back 45

Ceftriaxone single dose IM, plus chlamydia treatment unless ruled out

Front 46

Treatment for bacterial vaginosis?

Back 46

Metronidazole

Front 47

Treatment for fungal vaginosis?

Back 47

Fluconazole

Front 48

Standard and alternative treatments for Trichomonas vaginalis?

Back 48

Metronidazole; clindamycin

Front 49

Empiric recommendation for PID?

Back 49

Cefotetan + doxycycline (IV)

Front 50

PID oral therapy?

Back 50

Ceftriaxone (IM) + doxycycline +\- metronidazole

Front 51

Treatment and cause for epididymitis, if enteric organisms may be a concern?

Back 51

Ceftriaxone + doxycline (chlamydia, gonorrhea), and fluoroquinolone (E. coli, P. aeruginosa)