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12 Cards in this Set
- Front
- Back
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TNF-alpha is produced by which group of T-cells?
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T-helper 1 (Th1) cells
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What 4 other cytokines does TNF-alpha produce?
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1) IL-1
2) IL-2 3) G-CSF 4) IFN-gamma |
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Name the 3 TNF-apha inhibitors
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1) Etanercept
2) Infliximab 3) Adalimumab |
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What is the trade name for Etanercept?
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Enbrel
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What is the trade name for Infliximab?
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Remicade
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What is the trade name for Adalimumab?
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Humira
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Which 2 TNF-alpha inhibitors are fully human?
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Etanercept (Enbrel) and Adalimumab (Humira)
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This TNF-alpha inhibitor has the highest risk of developing anti-drug antibodies
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Infliximab (Remicade)
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Which TNF-alpha inhibitor is a Chimeric (25% mouse, 75% human) monoclonal IgG antibody?
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Infliximab (Remicade)
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Which TNF-alpha inhibitor is fully human fusion protein that binds to both TNF-alpha AND TNF-beta?
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Etanercept (Enbrel)
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Which TNF-alpha inhibitor is a fully human monoclonal IgG antibody that binds to TNF-alpha only?
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Adalimumab (Humira)
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Which TNF-alpha inhibitor is a chimeric IgG monoclonal antibody specific for TNF-alpha only?
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Infliximab (Remicade)
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