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15 Cards in this Set
- Front
- Back
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What are the 2 major categories of Cytotoxic agents?
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1) Alkylating Agents
2) Antimetabolites |
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Name the 5 commonly used antimetabolites
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1) Methotrexate
2) Azathioprine 3) Mycophenolate Mofetil 4) Hydroxyurea 5) 5-Fluorouracil |
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What are the 3 commonly used alkylating agents?
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1) Chlorambucil
2) Cyclophosphamide 3) Melphalan |
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The antimetabolites result in cell death by acting specifically on what phase of replication?
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S phase
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Alkylating agents exert their affects by chemically altering what?
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DNA regardless of timing
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Cytoxan is the trade name for what alkylating agent?
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Cyclophosphamide
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Which alkylating agent is derived from nitrogen mustard?
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Cyclophosphamide
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Cyclophosphamide is only FDA approved for treating what?
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Advanced mycosis fungoides
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What are the 3 most common adverse effects seen with Cyclophosphamide?
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1) Leukopenia
2) Hemorrhagic Cystitis 3) GI problems |
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CellCept is the trade name for what antimetabolite?
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Mycophenolate Mofetil
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Cyclophosphamide is cell cycle independent drug (alkylating agent) and depresses what cells specifically?
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B-cell function more than T-cells, and suppressor (CD8) T-cells more than Helper (CD4) T-cells
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Chlorambucil puts pts at significantly increased risk of developing what 3 cancers?
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1) Non-Hodgkin's B-cell Lymphoma
2) Acute Myelogenous Leukemia 3) SCC |
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CellCept inhibits de novo synthesis of what?
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de novo purine synthesis
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What is absolute contraindication for all the antimetabolites and alkylating agents?
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Pregnancy
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What blood changes are seen with Hydroxyurea use?
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Megaloblastic anemia
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