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33 Cards in this Set

  • Front
  • Back
cells that make bone?
-osteoprogenitor cells
-osteoblasts
-osteocytes
cells that break down bone?
-osteoclasts
job?
-osteoprogenitor cells
-osteoblast
-osteocyte
-develop into osteoblasts
-form matrix of bone
-maintain matrix of bone
salter-harris fracture
-definition?
-at growth plate; impt to fix properly
plastic deformation
-definition?
-force causes shape change rather than fracture (peds)
fractures indicitave of abuse trama?
-metaphyses corner
-diff stages of healing
-femoral, humeral, tibia in <1y/o
-scapular fracture
-posterior rib
-multiple skull
bone metaphyses corner fractures
-cause?
-usually twisting of finger/digit
stages in bone repair?
-inflammatory stage
-repair stage
-remodeling stage
inflammatory stage
-what happens?
-blood vessels rupture, blood clot seals fracture site,- allows for fibroblasts, osteoprogenitor cells,
repair stage
-what happens?
-osteoblasts, chondroblasts make bone/cartilage
remodeling stage
-what happens?
-thin layers bone build up
alkaline phosphatase
-what does it measure?
-enzyme assoc. w/osteoblastic activity; measure of bone deposition
hydroxyproline levels
-what do they measure?
-AA only in collagen; high levels/excretion in bone breakdown
levels of ALP and hydroxyproline in person with fracture?
-both high
serum calcium/phosphate
-abnormal levels tell you?
-bone related pathology
parathyroid hormone
-high levels mean?
-more osteoclastic activity, higher ca in blood
osteoporosis
-definition?
-clinical features?
-decreased bone mass
-back pain, screening, fracture (hip)
osteoporosis
-tests?
-path?
-treatment?
-dual-energy absorptiometry; not xray/ca/p
-porous, thinning bone
-ca/vit d, bisphosphonates, estrogen replacement
osteogenesis imperfecta
-definition?
-path?
-genetic disorders w/abnormal collagen; hypodense bone
-porous, thinning bone
osteitis fibrosa cystica (von recklinghausen bone dx)
-definition?
-diagnose?
-path?
-treatment?
-inc levels PTH, inc. osteoclastic activity, oxteolytic bone lesions
-dual energy absorpitimetry, labs
-"brown tumor"
-vit d, remove parathyroid
renal osteodystrophy
-definition?
-clinical sx?
-treatment?
-type of osteitis fibrosa cystica; hyperparathyroidism, ESRD
-renal failure, dec. bone mass, osteomalacia
-Ca, vit D
Rickets/Osteomalacia
-definition?
-dx?
-R(child) O(adults), Vit D deficiency, dec. calcification of bone matrix - soft bones
-xray, labs
rickets/osteomalacia
-clinical features?
-R: weak bones, bowed legs, skeletal deformities, late closing of fontanelles, pigeon breast, dec. height, rachitic rosary
O: osteopenia, osteomalacia
scurvy
-definition?
-vit C deficiency, impaired collagen form., dec. osteoid matrix formation
scurvy
-clinical features?
-weak capillaries: bleed gums, loose teeth, anemia; cork screw hairs, bone pain
osteopetrosis (albers-schonberg dx/ marble bone)
-definition?
-path?
-reduced osteoclastic resoprtion; inc. density w/hardening
-bone lacks medullary cavity
infantile malignant osteopetrosis
-inheritance?
-clinical sx?
-AR
-fractures, anemia, neutropenia, infections, death
adult osteopetrosis
-inheritance?
-clinical sx?
-AD
-repeated fractures, cranial nerve deficits, anemia
Paget's dx of bone (osteitis deformans)
-definition?
-onset?
-localized, abnormal bony architecture, inc. osteoclast/blast activity
-usually after 40 y/o; viral or genetic
Paget's dx
-stages?
-osteolytic: inc breakdown
-mixed osteolytic/osteoblastic
-osteosclerotic - inc. bone density
paget's disease
-clinical sx?
-dx?
-isolated to one bone, axial skeleton or proximal femur; fractures, nerve compression, osteoarthritis, tibial bowing
-inc. alkaline phosphatase, xray
paget's disease
-path?
-osteolytic phase: large osteoclasts
-mixed phase: woven bone, mosaic pattern
-ostersclerotic phase: thickened trabeculae and cortices
infectious osteomyelitis
-definition?
-dx?
infection of bone, inflammation; often from ulcer/lesion over bone
-xrays have mottled pattern