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44 Cards in this Set
- Front
- Back
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etiology of AML 11q23?
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monocytic morphology often found in infants
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multi-lineage dysplasia AML?
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often occur in older individuals
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which two chemo agents can cause secondary AML?
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alkylating agents or topoisomerase II inhibitors
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tx. of AML?
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chemo with ara-C and anthracycline
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dx. of AML?
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>20% blasts in bone marrow, commonly with auer rods
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tx. of AML t(15:17)?
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promyelocytic. caused by RARalpha-PML fusion protein. tx. with vit. A
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chronic myeloproliferative disorder?
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relatively normal and effective hematopoeisis resulting in increased number of cells and splenomegaly
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myelodysplastic sx.?
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often found in pt. over 50, increased cellularity but ineffective hematopoeisis
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which karyotype MDS has different progression than other MDS?
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5q-; more chornic course and does not progress to AML
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tx. of MDS?
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no definitive tx.; focused on supportive care
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difference between chronic myelomonocytic leukemia and other CMPS?
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anemia, thrombocytopenia, and marrow dysplasia similar to MDS found
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majority of ALL is involves which cell?
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precursor B-cells
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which surface markers commonly present in common ALL?
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CD9 and CD10
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two main cytological differences between AML and ALL?
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auer rods and myeloperoxidase
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Rai staging system of CLL?
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0= absolute lymphocytosis
1= plus enlarged lymph 2=plus enlarged liver and/or spleen 3=plus anemia 4= plus thrombocytopenia |
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which stain is positive in hairy cell leukemia?
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TRAP
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difference between hodgkin's and non-hodgkin's?
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hodgkin's- single disease, orderly spread affecting central LN, and extra-nodal rare
non-hodgkin's-mult. disease, non-orderly spread (hematogenous), peripheral LN, and extra-nodal common |
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which grade NHL is curable?
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high grade NHL
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"punch-out" lesions in bone indicate which disease?
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plasma cell myeloma
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cyclin D1 is positive in which lymphoma?
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mantle (from mantel layer surrounding germinal center in LN) cell lymphoma
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location of marginal zone?
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lymphocytes surrounding the mantle layer, most often in spleen, GI and salivary glands
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another name for extranodal MZL?
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MALT(mucosal associated lymphoid tissue)
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"starry-sky" pattern created by mult. nuclei in intermediate size cells, and associated with EBV in Africa is which type of lymphoma?
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Burkitt's
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cutaneous lymphoma involving CD4 cells?
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sezary syndrome
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reed-sternberg cell found in which lymphoma?
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hodgkin's
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B sx. in leukemia/lymphoma?
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fever, wt. loss, and night sweat
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which chromosome has c-myc oncongene found in burkitt's lymphoma?
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chromosome 8
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Ann Arbor staging?
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1- single or extranodal
2- 2 or more on same side of diaphragm 3- both sides of diaphragm 4- disseminated |
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risk factors in non-hodgkin's lymphoma according to IPI?
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age greater than 60y/o, abnormal LDH, performance status <2, stage, extranodal >1
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which group of pts. can benefit from transplants in relapse aggressive NHL?
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NHL that is chemosensitive
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main tx. option for NHL?
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CHOP and rituximab
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main cytometry marker used to differentiate CLL from Mantle cell NHL?
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CD22 positive in mantle cell
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tx. only indicated for which stages of CLL?
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stage III or stage IV
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most common indolent lymphoma worldwide?
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follicular center cell NHL; confirm with BCL2 (t14:18)
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FLIPI score?
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used to stage follicular center NHL: risks include age>60, stage III/IV, Hgb<12, 4 or more nodal sites, LDH>normal
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t(2:5)ALK fusion protein and CD30+ commonly found in males with mediastinal involvement indicate what disease?
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anaplastic large cell NHL
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cancer associated with H.pylori?
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MALT
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risk factors for hodgkin?
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family hx., high SES and education level, EBV, jewish religion
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classic genetic finding of burkitt?
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myc oncogene t(2:8), t(8:14,22), MATURE B cell lymphoma
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dx. stain for ALL?
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TDT stain
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only cancer where maintenance therapy is effective?
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ALL
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which 3 AML have good prognosis?
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t(8:21), t(15:17), inv(16)
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cord compression can be seen in which leukemia?
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mult. myeloma
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dx. of mult. myeloma by immunoglobin?
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IgA and kappa increase
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