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5 Cards in this Set
- Front
- Back
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What is the only DNA virus that does not replicate in the nucleus?
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Pox virus
therefor requires its own replication machinery in the cytoplasm must encode its own 7methyl guanosine transferease gene |
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what are the 3' and 5' caps on mRNA
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3' = poly A tail
5' = 7 methyl guanosine |
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For DNA viruses, what are the three types of late genes?
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-structural proteins (envelope and capsid)
- proteins for assembly - proteins for release |
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How do DNA viruses regulate the cell cycle?
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All DNA viruses except Parvoviruses, trick the cell into starting into S phase and then stop the process just before host cell DNA replication would begin.
This puts the cell in the optimum state to support viral genome replication and viruses use many of these proteins for replication. The viral genes involved are the E/IE regulatory genes If the infection is aborted and the cell survives while expressing the viral proteins that trigger this process, the cells can be transformed and eventually cancerous. |
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What are the four ways that DNA viruses solve the genome end problem?
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1) circularlize genome (no ends)
2) pre-terminal proteins 3) Rolling Circle mechanism (herpes) 4) Joined ends via Inverted Terminal Repeats (Pox) |
