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108 Cards in this Set
- Front
- Back
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Polymviridae (class) |
dsDNA |
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Adenoviridae (class) |
dsDNA |
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Poxviridae (class) |
dsDNA |
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Hepadna viruses (class) |
Gapped ssDNA |
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Paroviridae (class) |
ssDNA |
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Reoviridae (class) |
dsRNA |
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Poliovirus (class) |
+ssRNA |
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Retroviridae (class) |
+ssRNA with DNA intermediate |
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Orthomyxoviridae (class) |
-ssRNA |
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Filoviridae |
-ssRNA |
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~80% of North Americans are infected asymptatically |
JCV > polymaviridae |
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Two dsDNA virus families that rely on host RNA polymerase |
Polymaviridae and Adenoviridae |
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dsDNA virus family that uses it's own RNA pol |
Poxviridae |
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Causes infections in cats and dogs (family and class) |
Paroviridae > ssDNA |
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Most important cause of gastroenteritis in developing world |
Reoviridae (dsRNA) |
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Cause mucosal infections (including influenza) |
Orthomyoviridae |
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What is the significance of the L-protein? |
Found in Ebola > it's the RNA dependent RNA pol (-ssRNA genome) |
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Is Ebola enveloped? |
Yes |
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Is Ebola enveloped? |
Yes |
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What receptor does Ebola recognize in what structure? |
NPC-1 in late endosome |
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What type of symmetry does the measles virus exhibit? |
Helical |
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Host receptor for measles |
CD46 |
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Is polio enveloped? How does it become encapsulated? |
No > 5 folded and cleaved P1 peptides (VP1/2/3/4) come together to form pentamere, 12 pentamere a to form capsid |
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How does poliovirus enter cells? |
VP1 N-termini conformational change @ PM to inject +ssRNA genome directly |
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Is influenza enveloped? |
Yes |
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Influenza glycoprotein ____ interacts with ______ |
Hemagglutinin > solace acid with 2-6 linkages preferrably |
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What symmetry does the Norwalk virus have? |
Quasiequivalent isosahedral geometry (180 identical subunits) |
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The 2 viruses from the flaviridae family |
Dengue and west Nile |
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The 2 viruses from the flaviridae family |
Dengue and west Nile |
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Flaviridae (class) |
+ssRNA READY TO GO |
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Dengue virus fusion protein is activated in _____ |
Late endosome |
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Does west Nile have an envelope? |
Yes |
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Virus family that enter nucleus using microtubules |
Herpesviridae |
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Flaviridae (class) envelope? |
+ssRNA READY TO GO (envelope +) |
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Viremia |
Presence of visions in the blood |
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Viremia |
Presence of visions in the blood |
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Primary viremia |
Progeny visions released in blood after initial replication at site of entry |
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Viremia |
Presence of visions in the blood |
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Primary viremia |
Progeny visions released in blood after initial replication at site of entry |
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Secondary viremia |
Delayed appearance of visions in blood |
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pH of skin |
5.5 |
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West Nile gains access to |
Vascularized dermis |
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Rhinovirus causes |
Common cold |
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Rhinovirus causes |
Common cold |
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Reoviruses (transmission method and envelope?) |
Ailmentary and non-enveloped |
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Rhinovirus causes |
Common cold |
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Reoviruses (transmission method and envelope?) |
Ailmentary and non-enveloped |
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Rhinovirus (transmission method and envelope?) |
Respiratory and enveloped |
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Influenza (transmission method and envelope?) |
Respiratory via aerosols and enveloped |
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Adenoviruses (transmission and envelope?) |
Conjunctiva and non-enveloped |
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Iatrogenic |
Health care worker to patient |
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Nosocomial |
Patient infected while in hospital |
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Vertical |
Parent to offspring |
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Germline |
Genomic transfer from parent to offspring |
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Horizontal |
Transmission between two of the same or different species |
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Picornaviridae (disease it causes, class, transmission method and enveloped?) |
HepA > +ssRNA > alimentary tract > nonenveloped |
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Picornaviridae (disease it causes, class, transmission method and enveloped?) |
HepA > +ssRNA > alimentary tract > nonenveloped |
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Incubation time for HepA |
30 days |
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Two emerging diseases in 1980's from AIDS |
Pneumocytosis and kaposi sarcoma |
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HAART |
Highly active antiretroviral therapy |
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HIV (family, subfamily, enveloped?) |
Retroviridae > lentiviruses > enveloped |
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What cellular compartment does RT happen in? |
Cytoplasm |
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What cellular compartment does RT happen in? |
Cytoplasm |
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HIV-1 glycoproteins (and function) |
gp120 (surface protein) and gp41 (fusion) |
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What cellular compartment does RT happen in? |
Cytoplasm |
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HIV-1 glycoproteins (and function) |
gp120 (surface protein) and gp41 (fusion) |
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HIV-1 capsid protein is called |
p24 |
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Host HIV-1 receptor and co-receptor proteins |
CD4 and CCR5/CXCR4 |
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Host HIV-1 receptor and co-receptor proteins |
CD4 and CCR5/CXCR4 |
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RT lacks what function |
3' to 5' expo nuclear activity |
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Host HIV-1 receptor and co-receptor proteins |
CD4 and CCR5/CXCR4 |
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RT lacks what function |
3' to 5' expo nuclear activity |
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Gag |
Matrix and capsid proteins |
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Host HIV-1 receptor and co-receptor proteins |
CD4 and CCR5/CXCR4 |
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RT lacks what function |
3' to 5' expo nuclear activity |
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Gag |
Matrix and capsid proteins |
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Pol |
Makes RT, integrase and protease for polyproteins |
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Group M stands for |
Major |
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Group O stands for |
Outlier |
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Most prevalent group of HIV-1 in the world |
Group C |
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Most virulent group of HIV-1 in the world |
Group D |
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Group CRF is found mainly in |
Sex workers |
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Group CRF is found mainly in |
Sex workers |
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96% of white homos in SA |
Group B |
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Species of chimp responsible for transmitting HIV-1 to humans |
Pan tryglodytes tryglodytes |
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Calcivirus infects |
Whales |
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Calcivirus infects |
Whales |
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Calcivirus causes |
Gastroenteritis and rashes |
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HERVs |
Endogenous retroviruses |
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What percentage of our genome is derived from HERVs? |
10% |
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Herpes in Latin means |
To creep or crawl |
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The time it takes to assemble the vision before any new visions have been assembled |
Latent period |
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The time during which infectivity disappears |
Eclipse |
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The time during which there is assembly of genome and viral protein |
Maturation period |
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Cell that contains a functional receptor for a virus to attach to is called |
Susceptible |
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A cell that allows the virus to replicate is called |
Permissive |
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Fusion of adjacent PNs that results in multinucleated cells |
Synctia |
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Cells are no longer flat but divide uncontrollably to form foci |
Transformation |
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Adenovirus receptors |
CAR and integrin |
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The lower a particle to PFU ratio, the _____ infectious a virus is |
More |
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The larger the diameter of the RBCs in a hemagglutination assay, the _____ amount of virus |
Less |
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Viral enzyme activity assays can only be done for |
Retroviruses |
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Radioactive _____ was found in second generation of cells in Hershey chase experiments |
Phosphorous |
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mRNA is read by ribosomes in the _____ direction |
5' to 3' |
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+ssRNA viruses need a _____ polymerase |
DNA dependent RNA polymerase |
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HepB has a ___ particle to PFU ratio |
Low > it's very infectious |
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Rhinovirus host receptor |
LDL receptor |
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Poliovirus receptor |
PVR |
