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34 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Largest pathogenic virus Largest genome |
Pox |
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Smallest pathogenic virus - parvovirus |
Smallest genome - HBV |
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ss rna with RT - retro |
Ds dna with rt - HBV |
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Env made of ___ except ___ made of ___ |
Env made of host cell membrane except HBV made of ER |
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Nonionic detergent - triton x-100 |
Ionic detergent - SDS ( sodium dodecyl sulfate) |
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Virus which can't be preserved by lyophilisation |
Polio |
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Von magnus phenomenon |
H. Influenza |
Undiluted high dose of H. Influenza with heamagglutinin spikes |
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Genetically defective virus |
HDV |
Replicate only in presence of HBV |
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ss DNA virus Fever malaise Slapped cheek Erythema infectiosum Glove sock syndrome ( painful purpuric swelling) Symmetrical small joint pain Transient aplastic crisis in hemolytic anemia Pure red cell aplasia in immunosupressed Non immune hydrops fetalis Cells : EPEPML |
Parvovirus
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NS 1 and VP 1&2 |
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Respiratory: Actue pharyngitis - 1 to 7 Pharyngoconjunctival fever ( swimming pool conjunctivitis) - 3 , 7 Pneumonia - 3,7,14 Acute resp illness in military - 3,7,14,21 Eye - epidemic keratoconjunctivitis 8,19,37 Git - diarrhoea 40,41 Git - diarrhoea 40,41Urinary tract - hemorrhagic cystitis 11,21 Urinary tract - hemorrhagic cystitis 11,21 |
Adenovirus 12,18,37 oncogenic in animals Not a oncogenic virus in humans |
Cultivable only from human cells Live attenuated vaccine for military No specific Rx 240 + 12 6 and 57 serotypes Cancer and gene therapy |
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Latent in kidneys Reactivation in HIV/ TR/ immunosup Rx/ Hodgkin lymphoma Subacute demyelinating ds - PMLE on reactivation Brain Bx - gold std No Rx Invariably fatal |
JC virus |
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Latent in kidney Reactivation in TR Interstitial nephritis & urethral stones in renal TR Hemorrhagic cystitis in BM TR |
BK virus |
Rx: reduce level of immunosuppression |
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Polyoma virus |
Large tumor Ag & small tumor Ag VP 1,2&3 Circular genome All are oncogenic |
1. JC 2. BK 3. Simian virus 40 4. Merkel cell CA virus 5. KI 6. WU 7. Trichodysplasia spinulosa ass polyoma virus |
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Papilloma virus |
Regulatory region L1&L2 ( structural) E1,2,4,5,6,7 (6 nonstructural) Circular genome No serotypes ( only genotypes as they are not cultivable) E6 - p53 & E7- pRb All are oncogenic |
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Koilocytes |
HPV inf |
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162 capsomers Tegument btw envelope and capsid Latency and reactivation Focal degeneration |
Herpes virus |
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Intanuclear owl eye inclusion bodies |
CMV |
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Ballooning degeneration of intraepithelial cells ( vesicles) Scraping from base of ulcer - multinucleated giant calls called Tzanck cells and eosinophilic inclusion bodies |
HSV 1&2 |
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Gigivostomatitis Pharyngitis Herpes labialis Herpes Gladiatorum Genital herpes Herpetic whitlow Keratoconjunctivitis ( dentritic ulcer) Eczema herpeticum Sporadic encephalitis ( temporal lobe) Mollaret meningitis Transverse myelitis GBS Bells palsy Neonates : skin with eye involvement, encephalitis, disseminated ds |
HSV 1&2 |
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2 days before and 5 days after rash IP- 7-23 days Superficial centripetal rash Dew Drop on rose petal - unilocular vescicle surrot by erythema Pleomorphic rash Tzanck smear - MNG cells Elisa / FAMA ( immunoflurescent Ab test) Sec bacterial inf Benign cerebellar ataxia Varicella pneumonia ( adults and pregnant women) Meningitis, encephalitis, Transverse myelitis, GBS |
VZV |
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Tzanck cells |
HSV 1&2 VZV |
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Doc for CMV |
Ganciclovir |
Others : foscarnet, valganciclovir, sedofovir |
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Mc agent transmitted across placenta Mcc of opportunistic inf in HIV and TR ( max in 1-4 months) |
CMV |
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Diploid cell lines |
BK virus CMV Havrix |
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CD4 < 50 |
CMV |
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Mcc of blindness in HIV |
CMV chorioretinitis / pizza pie retinopathy / cottage cheese and sauce |
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Paschen / Guarneri inclusion bodies |
Small pox ( variola) |
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Mcc of epidemic encephalitis in Asia |
JE |
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Plaque reduction neutralisation test |
Confirmatory test after IgM elisa: Dengue Zika JE |
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IgG Rx |
Perinatal / neonatal varicella Pure red cell aplasia in parvo B19 infection |
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Antivirals |
HSV1&2 CMV |
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Tick borne encephalitis |
Russian spring summer encephalitis Powasson encephalitis Louping lu |
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18 HA 11 NA H-1, 2,3,5,7,9 N-1, 2 can infect humans |
All can infect birds |
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