Virology

Front 1

Dengue virus is a (+)ssRNA virus. The viral RNAs prepared from DENV-infected cells are infectious and can initiate virus replication cycle after introduced into culture cells.

Back 1

TRUE

Front 2

Interactions between protein subunits in a viral capsid are noncovalent.

Back 2

TRUE

Front 3

Hemagglutination assay can be used to measure the infection units of a virus stock.

Back 3

FALSE

Front 4

According to Baltimore classification, dsRNA viruses can translate protein directly from the viral RNA genome.

Back 4

FALSE

Front 5

Both direct and indirect fluorescent antibody assay can be used for viral antigen detection.

Back 5

TRUE

Front 6

Neutralizing antibody is able to block virus infectivity, and can be used to distinugish different virus serotype.

Back 6

TRUE

Front 7

Smallpox is the only human infectious viral disease that has been completely eradicated from nature.

Back 7

TRUE

Front 8

All RNA viruses replicate in cytoplasm.

Back 8

FALSE

Front 9

Dengue virus polyprotein is processed only by viral protease.

Back 9

FALSE

Front 10

Subgenomic RNAs are usually not packaged in virion.

Back 10

TRUE

Front 11

Defective virus may interfere with replication of the wild-type virus.

Back 11

TRUE

Front 12

Some enveloped viruses acquire the envelope from plasma membrane, and some can acquire the envelope from the membrane of the intracellular compartment.

Back 12

TRUE

Front 13

Glycosylation (modification with sugar residues) of viral envelop proteins starts in ER, and continues in Golgi.

Back 13

TRUE

Front 14

For both (+) and (-) RNA viruses, the templates of RdRPs are nake RNA.

Back 14

FALSE

Front 15

Infectious cDNA clone of (+)RNA virus is an effective reverse genetic approach to study the function of a viral gene.

Back 15

TRUE

Front 16

Viruses have no active way of entering plants. They rely upon the wounds made by mechanical damage or by insects.

Back 16

TRUE

Front 17

Receptor-mediated cell entry of a nonenveloped virus is a pH-independent process.

Back 17

FALSE

Front 18

For DNA viruses, viral mRNAs are generally synthesized by viral RNA polymerases.

Back 18

FALSE

Front 19

The receptor molecules on cell surfaces for virus infection may be proteins or the sugar resides present on glycoproteins.

Back 19

TRUE

Front 20

Hepatitis A virus and hepatitis C virus have a similar route of transmission.

Back 20

FALSE

Front 21

Different viruses may attach to the same receptor on the cell surface

Back 21

TRUE

Front 22

Rhinoviruses and Rubella virus are the major pathogens that cause common cold.

Back 22

FALSE

Front 23

HIV-1 mRNAs is synthesized by cellular RNA polymerase

Back 23

TRUE

Front 24

mRNAs of most RNA viruses acquire 5' cap using host cellular enzymes.

Back 24

FALSE

Front 25

Retroviruses integrate their cDNAs into the host genome

Back 25

TRUE

Front 26

In nucleus, transcription of the adenoviral VA-RNAs is mediated by host RNA polymerase III.

Back 26

TRUE

Front 27

Splicing of influenza viral mRNA occurs in the cytoplasm.

Back 27

FALSE

Front 28

Stress or immunosuppression can be the cause of reactivation of a latent infection.

Back 28

TRUE

Front 29

The HIV proviral DNA is an exact cDNA copy of a viral genome RNA.

Back 29

FALSE

Front 30

Hepatitis B virus is a DNA virus, but encodes a reverse transcriptase.

Back 30

TRUE

Front 31

Herpesvirus VP16 protein is the product of a late gene, but is required early during infection.

Back 31

TRUE

Front 32

During HIV replication, the viral mRNA also serves as a genome for viral assembly and particle production.

Back 32

TRUE

Front 33

Oncogenes of DNA viruses are usually essential for viruses life cycle.

Back 33

TRUE

Front 34

Retroviral oncogenes are derived from host cellular genes, but not required for viral replication.

Back 34

TRUE

Front 35

Host immune response against viral infection may contribute viral pathogenesis.

Back 35

TRUE

Front 36

A virulent virus may become attenuated if passaged into different host cells.

Back 36

TRUE

Front 37

Antiviral drugs only target at a specific viral function, not a host cellular process.

Back 37

FALSE

Front 38

Antigenic shift in influenza A virus is the major determinant for a significant flu pandemic.

Back 38

TRUE

Front 39

The profound immunosuppression seen in AIDS is due to the depletion CD4+T cells by HIV infections.

Back 39

TRUE