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9 Cards in this Set
- Front
- Back
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Vasculitis |
Inflammation and necrosis of blood vessel wall Can be cutaneous and form papules, lesions, and nodules Can involve multiple organs Caused by phenytoin, beta-lactam antibiotics, and sulfonamides |
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Serum Sickness |
Occurs 7-14 days after Ag administration Symptoms include fever, malaise, and lymphadenopathy Causes: phenytoin, sulfonamides, penicillins, cephalosporins |
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Drug Fever |
Variable pattern, discontinuing drug resolves fever Suggested mechanism is CNS effect on temperature regulation, stimulation of endogenous pyrogens Causes: variety of drugs |
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Drug induced autoimmunity |
Drug induced SLE Caused by hydralazine, procainamide Commonly causes arthralgia, myalgia, and polyarthritis Can involve kidney and pulmonary function Develops several months after starting treatment |
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Exanthematous Drug Eruption |
Also known as morbilliform or maculopapular drug rash Appear 4-21 days after starting drug Symptoms include pruritic, pink macules and papules that spread Patients at higher risk if have HIV, bone marrow transplant D/C offending agent, treat with topical glucocorticoid |
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Erythema Multiforme |
Acute, self limited hypersensitivity reaction Triggered by infection (90%) Form macules and papules on extremities that form lesions Use supportive therapy, limited epidermal detachment |
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Stevens-Johnson syndrome and Toxic Epidermal Necrolysis |
Rare and life-threatening Many drugs can cause this reaction Epidermal detachment of varying severity Usually includes prodromal phase of fever, sore throat, stinging eyes for 1-3 days, followed by mucosal erosion, cutaneous lesions, and necrotic dermatitis |
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Drug reaction with eosinophilia and systemic symptoms (DRESS) |
Potentially life-threatening Consists of severe skin eruption, fever, and hematologic abnormalities Involves internal organs Delayed onset 2-6 weeks after beginning drug D/C drug as soon as possible Main causes are carbamazepine, allopurinol, sulfasalazine, and lamotrigine |
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Acute generalized exanthematous pustulosis (AGRP) |
Rare, acute, self limiting eruption with a favorable prognosis Forms sterile pustules on face, trunk, and limbs Causes include antibiotics, CCBs, and antimalarials Treatment includes D/C drug and supportive care for 2 weeks |
