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64 Cards in this Set

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Tb drug that Inhibits arabinosyl transferase
Ethambutol
Which thyroid cancer:
Psammoma bodies
Papillary
Which thyroid cancer:
Eosinophilic cytoplasm
Follicular

Eosinophilic cytoplasm = Hurthle cells
Which thyroid cancer:
Ground glass appearance
Papillary
Calculate filtration fraction given:
RBF = 1.0 L/min
GFR = 0.1 L/min
HCT = 0.50
FF = RBF/RPF
RPF = (1-HCT)*(RBF)= Cl(PAH)

Thus,
RPF = .5*1 = 0.5
FF= GFR/RPF=.1/0.5=0.2
Which syndrome:
Meningiomas
NF-1
Cardiomyopathy caused by:
Doxarubacin
Dilation-->Systolic Dysfn
Which thyroid cancer:
Amyloid deposits
Medullary
Which thyroid cancer:
Arises from parafollicular calcitonin-releasing cells
Medullary
High and Low potency antipyschotics
High Potency:
Haloperidol
Fluphenazine
Pimozide (is this the one that metabolizes to phenobarbitol?)

Low Potency:
Chlorpromazine
Thioridazine
(High risk anti-chol/histamine fx, low risk EPS)
Formula for attributable risk percent
ARP = RR-1/RR
Tumor cells expressing CD31
Hepatic angiocarcinoma

Note: CD31 - PECAM (important for leukocyte extravasation)
This disease has deficient lysyl hydroxylase
Ehlers-danlos

AKA pro-collagen peptidase
This disease targets antibodies against Type IV collagen
Goodpasture's
Crescent formation
Deposits of IgG, C3
Goodpasture
SIADH:
Salt levels
Fluid levels
Low salt (decreased aldosterone secondary to fluid retention)

Euvolemic
Morphine effects on ion channels.
Inc'd K+ efflux leads to hyperpolarization of postsynaptic neuron

Results in termination of pain transmission
Sickle Cell patient with aplastic crisis secondary to this virus.
Parvo
Hepatitis E:
Virus type
Unenveloped ssRNA
Diastolic murmur that diminishes with atrial fibrillation
Mitral stenosis (or TC stenosis)?
Bacteria that activate adenylate cyclase via ADP ribosylation.
Note that this increases cAMP in host cells

Pertussis
Cholera
E. coli in presence of:
Glucose
Lactose
Glucose: dec'd adenylyl cyclase activity-->dec'd intracell cAMP
-->dec'd lac operon genes
(in absence of glucose-->inc'd intracell cAMP-->activates Catabolite Activator Protein-->positive regulates lac operon)

Lactose:
Conformational change in repressor gene, releases from operator
Allows inc'd transcription of lac operon
Hemiballismus:
Brain lesion
Contralateral lesion of SUBTHALAMIC NUCLEUS
Lacunar stroke
h/o HTN
Reactions that require NADPH
FA synthesis
Steroid synthesis
Cholesterol synthesis
Drug metabolism
Lepirudin MOA
Direct thrombin inhibitor
Which virus:
dsDNA-->template +RNA-->progeny dsDNA
HBG because has reverse transcriptase
Which virus:
dsDNA-->Template dsDNA-->Progeny dsDNA
Herpes
<1 g proteinuria qd
RBC Casts

Nephritic/Nephrotic
Example
Nephritic
PSGN
P>3.5g qd
No RBC Casts

Nephritic/Nephrotic
Example
Nephrotic Syndrome
Minimal Change Disease
Effect of opioids on gall bladder.
Contracts sphincter-->biliary colic
Bacteria that inactivates 60S ribosome
E coli 0157 (can lead to microangiopathic hemolytic anemia)
E coli that doesn't ferment sorbitol.
E coli 0157
50 year-old male with sudden severe headache, double vision, and bitemporal hemianoopsia.

He's noticed decreased libido and mild headaches for a few months.

Diagnosis
Pre-existing pituitary adenoma explains dec'd libido and HA; must be bleeding into the adenoma

Called Pituitary Apoplexy
This thyroid disorder features giant cells.
Subacute granulomatus thyroiditis
2 year-old male with non-rhythmic conjugate eye movements.
neuroblastoma in adrenal medulla

Will find inc'd catechols in urine
This disorder results in excess release of gastrin.
Zollinger-Ellison
Chronic gastritis with antral sparing
Autoimmune (Pernicious Anemia)
Chronic gastric focused in antrum
H pylori
Alcoholic undergoes CT and reveals fluid filled cyst in pancreas.
How did that get there?
What's its lining like?
It's actually a pseudopsyst which formed due to leak of proteolytic enzymes, causing inflammation and granulation tissue

It's not lined by epithelium, that'd be a true cyst
Defect in excretion of bilirubin glucuronide products.

Name of disease
Presentation of patient?
Dubin JohnsonSyndrome

Self-resolving jaundice with pigmented hepatocytes (filled with epinephrine metabolites)
Anti-Jo 1
Polymyositis

Will have inc'd creatine kinase too
Sarcolemma will express MHCI's
Recurrent hemorrhage in the elderly:
What product of aging leads to this?
Amyloid deposition in vessels
Depolarizing drug with rapid onset and residual muscle paralysis
Succinylcholine
Non-depolarizing drug, reversible with -stigmine.
Curare drugs
Uterine adrenergic receptor is ____.
What's the effect of stimulating it?
Beta2-->uterine relaxation
Linear deposition of IgG, C3.
Goodpasture
Lumpy deposition of IgG, C3.
PSGN
Xanthoma on eye is associated with ______.
PBC
Which malignancy:
HIV positive
Ki-67 > 90%
Burkitt's lymphoma secondary to chronic EBV
Bacteria that utilize edema factor.
Bacillus anthracis (inc'd cAMP in host cells-->edema)

Pertussis
Liver cells with PAS-positive granules
unreleased alpha-A1T-->risk HCC
CD markers for Th0.
CD3 (transmits signal to cell interior)
CD4
Loe APO E3/E4
Thi is familial dysbetalipoproteinemia:
Liver isn't able to remove chylomicrons and VLDL from circulation
Accumulates in blood
Inc'd cholesterol/TG
Waxing/waning LAD
B cell follicular lymphoma
MTX AEs
Stomatitis
Hepatotoxicity (hepatitis, cirrhosis, fibrosis)
Bacteria with IgA protease
Strep pneumo
Neisseria
Bacteria with hemolysin
Staph
Bacteria with protein A
Staph Aureus (binds Fc of Igg to inhibit complement and dec C3b--impairs opsonization)
Infliximab MOA
Anti-TNF-alpha
Embryonic origin of:
Aorticopulmonary septum
NCC
Lack of UGT:

Which biliary disorder? Effect?
Criggler-Najjar 1

Leads to inc'd INDIRECT (UNCONJUGATED) blirubin--> deposits in brain-->kernicterus
Why do Zencker diverticula form?
Cricopharyngeal muscle dysfn
Which vitamin deficiency:
Edema, orthopnea, tachycardia
Thiamine--B1; this is wet beriberi
Which vitamin deficiency:
Difficulty walking, tingling in hands and feet, involuntary eye movements
Thiamine--B2; this is dry beriberi