Uworld: Last Licks

Front 1

Tb drug that Inhibits arabinosyl transferase

Back 1

Ethambutol

Front 2

Which thyroid cancer:
Psammoma bodies

Back 2

Papillary

Front 3

Which thyroid cancer:
Eosinophilic cytoplasm

Back 3

Follicular

Eosinophilic cytoplasm = Hurthle cells

Front 4

Which thyroid cancer:
Ground glass appearance

Back 4

Papillary

Front 5

Calculate filtration fraction given:
RBF = 1.0 L/min
GFR = 0.1 L/min
HCT = 0.50

Back 5

FF = RBF/RPF
RPF = (1-HCT)*(RBF)= Cl(PAH)

Thus,
RPF = .5*1 = 0.5
FF= GFR/RPF=.1/0.5=0.2

Front 6

Which syndrome:
Meningiomas

Back 6

NF-1

Front 7

Cardiomyopathy caused by:
Doxarubacin

Back 7

Dilation-->Systolic Dysfn

Front 8

Which thyroid cancer:
Amyloid deposits

Back 8

Medullary

Front 9

Which thyroid cancer:
Arises from parafollicular calcitonin-releasing cells

Back 9

Medullary

Front 10

High and Low potency antipyschotics

Back 10

High Potency:
Haloperidol
Fluphenazine
Pimozide (is this the one that metabolizes to phenobarbitol?)

Low Potency:
Chlorpromazine
Thioridazine
(High risk anti-chol/histamine fx, low risk EPS)

Front 11

Formula for attributable risk percent

Back 11

ARP = RR-1/RR

Front 12

Tumor cells expressing CD31

Back 12

Hepatic angiocarcinoma

Note: CD31 - PECAM (important for leukocyte extravasation)

Front 13

This disease has deficient lysyl hydroxylase

Back 13

Ehlers-danlos

AKA pro-collagen peptidase

Front 14

This disease targets antibodies against Type IV collagen

Back 14

Goodpasture's

Front 15

Crescent formation
Deposits of IgG, C3

Back 15

Goodpasture

Front 16

SIADH:
Salt levels
Fluid levels

Back 16

Low salt (decreased aldosterone secondary to fluid retention)

Euvolemic

Front 17

Morphine effects on ion channels.

Back 17

Inc'd K+ efflux leads to hyperpolarization of postsynaptic neuron

Results in termination of pain transmission

Front 18

Sickle Cell patient with aplastic crisis secondary to this virus.

Back 18

Parvo

Front 19

Hepatitis E:
Virus type

Back 19

Unenveloped ssRNA

Front 20

Diastolic murmur that diminishes with atrial fibrillation

Back 20

Mitral stenosis (or TC stenosis)?

Front 21

Bacteria that activate adenylate cyclase via ADP ribosylation.

Back 21

Note that this increases cAMP in host cells

Pertussis
Cholera

Front 22

E. coli in presence of:
Glucose
Lactose

Back 22

Glucose: dec'd adenylyl cyclase activity-->dec'd intracell cAMP
-->dec'd lac operon genes
(in absence of glucose-->inc'd intracell cAMP-->activates Catabolite Activator Protein-->positive regulates lac operon)

Lactose:
Conformational change in repressor gene, releases from operator
Allows inc'd transcription of lac operon

Front 23

Hemiballismus:
Brain lesion

Back 23

Contralateral lesion of SUBTHALAMIC NUCLEUS
Lacunar stroke
h/o HTN

Front 24

Reactions that require NADPH

Back 24

FA synthesis
Steroid synthesis
Cholesterol synthesis
Drug metabolism

Front 25

Lepirudin MOA

Back 25

Direct thrombin inhibitor

Front 26

Which virus:
dsDNA-->template +RNA-->progeny dsDNA

Back 26

HBG because has reverse transcriptase

Front 27

Which virus:
dsDNA-->Template dsDNA-->Progeny dsDNA

Back 27

Herpes

Front 28

<1 g proteinuria qd
RBC Casts

Nephritic/Nephrotic
Example

Back 28

Nephritic
PSGN

Front 29

P>3.5g qd
No RBC Casts

Nephritic/Nephrotic
Example

Back 29

Nephrotic Syndrome
Minimal Change Disease

Front 30

Effect of opioids on gall bladder.

Back 30

Contracts sphincter-->biliary colic

Front 31

Bacteria that inactivates 60S ribosome

Back 31

E coli 0157 (can lead to microangiopathic hemolytic anemia)

Front 32

E coli that doesn't ferment sorbitol.

Back 32

E coli 0157

Front 33

50 year-old male with sudden severe headache, double vision, and bitemporal hemianoopsia.

He's noticed decreased libido and mild headaches for a few months.

Diagnosis

Back 33

Pre-existing pituitary adenoma explains dec'd libido and HA; must be bleeding into the adenoma

Called Pituitary Apoplexy

Front 34

This thyroid disorder features giant cells.

Back 34

Subacute granulomatus thyroiditis

Front 35

2 year-old male with non-rhythmic conjugate eye movements.

Back 35

neuroblastoma in adrenal medulla

Will find inc'd catechols in urine

Front 36

This disorder results in excess release of gastrin.

Back 36

Zollinger-Ellison

Front 37

Chronic gastritis with antral sparing

Back 37

Autoimmune (Pernicious Anemia)

Front 38

Chronic gastric focused in antrum

Back 38

H pylori

Front 39

Alcoholic undergoes CT and reveals fluid filled cyst in pancreas.
How did that get there?
What's its lining like?

Back 39

It's actually a pseudopsyst which formed due to leak of proteolytic enzymes, causing inflammation and granulation tissue

It's not lined by epithelium, that'd be a true cyst

Front 40

Defect in excretion of bilirubin glucuronide products.

Name of disease
Presentation of patient?

Back 40

Dubin JohnsonSyndrome

Self-resolving jaundice with pigmented hepatocytes (filled with epinephrine metabolites)

Front 41

Anti-Jo 1

Back 41

Polymyositis

Will have inc'd creatine kinase too
Sarcolemma will express MHCI's

Front 42

Recurrent hemorrhage in the elderly:
What product of aging leads to this?

Back 42

Amyloid deposition in vessels

Front 43

Depolarizing drug with rapid onset and residual muscle paralysis

Back 43

Succinylcholine

Front 44

Non-depolarizing drug, reversible with -stigmine.

Back 44

Curare drugs

Front 45

Uterine adrenergic receptor is ____.
What's the effect of stimulating it?

Back 45

Beta2-->uterine relaxation

Front 46

Linear deposition of IgG, C3.

Back 46

Goodpasture

Front 47

Lumpy deposition of IgG, C3.

Back 47

PSGN

Front 48

Xanthoma on eye is associated with ______.

Back 48

PBC

Front 49

Which malignancy:
HIV positive
Ki-67 > 90%

Back 49

Burkitt's lymphoma secondary to chronic EBV

Front 50

Bacteria that utilize edema factor.

Back 50

Bacillus anthracis (inc'd cAMP in host cells-->edema)

Pertussis

Front 51

Liver cells with PAS-positive granules

Back 51

unreleased alpha-A1T-->risk HCC

Front 52

CD markers for Th0.

Back 52

CD3 (transmits signal to cell interior)
CD4

Front 53

Loe APO E3/E4

Back 53

Thi is familial dysbetalipoproteinemia:
Liver isn't able to remove chylomicrons and VLDL from circulation
Accumulates in blood
Inc'd cholesterol/TG

Front 54

Waxing/waning LAD

Back 54

B cell follicular lymphoma

Front 55

MTX AEs

Back 55

Stomatitis
Hepatotoxicity (hepatitis, cirrhosis, fibrosis)

Front 56

Bacteria with IgA protease

Back 56

Strep pneumo
Neisseria

Front 57

Bacteria with hemolysin

Back 57

Staph

Front 58

Bacteria with protein A

Back 58

Staph Aureus (binds Fc of Igg to inhibit complement and dec C3b--impairs opsonization)

Front 59

Infliximab MOA

Back 59

Anti-TNF-alpha

Front 60

Embryonic origin of:
Aorticopulmonary septum

Back 60

NCC

Front 61

Lack of UGT:

Which biliary disorder? Effect?

Back 61

Criggler-Najjar 1

Leads to inc'd INDIRECT (UNCONJUGATED) blirubin--> deposits in brain-->kernicterus

Front 62

Why do Zencker diverticula form?

Back 62

Cricopharyngeal muscle dysfn

Front 63

Which vitamin deficiency:
Edema, orthopnea, tachycardia

Back 63

Thiamine--B1; this is wet beriberi

Front 64

Which vitamin deficiency:
Difficulty walking, tingling in hands and feet, involuntary eye movements

Back 64

Thiamine--B2; this is dry beriberi