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67 Cards in this Set

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Associated Neoplasm: Down Syndrome
ALL, AML
Associated Neoplasm: Xeroderma pegmetosum, albinism
Melanoma, basal cell carcinoma, and especially squamous cell carcinoma
Associated Neoplasm: Chronic atrophic gastritis, pernicious anemia
Gastric Adenocarcinoma
Associated Neoplasm: Tuberous sclerosis (facial angiofibroma, seizures, mental retardation)
Astrocytoma, Angiomyolipoma, and cardiac rhabdomyoma
Associated Neoplasm: Actinic keratosis
Squamous Cell Carcinoma of skin
Associated Neoplasm: Barrett's Esophagus
Esophageal Adenocarcinoma
Associated Neoplasm: Plummer-Vinson Syndrome (atrophic glossitis, esophageal webs, anemia; all due to Fe def)
Squamous Cell Carcinoma of esophagus
Associated Neoplasm: Cirrhosis
Hepatocellular Carcinoma
Associated Neoplasm: Ulcerative Colitis
Colonic Adenocarcinoma
Associated Neoplasm: Paget's disease of the bone
Secondary osteosarcoma
Fibrosarcoma
Associated Neoplasm: Immunodeficiency States
Malignant Lymphomas
Associated Neoplasm: AIDS
Aggressive Malignant Lymphoma
Associated Neoplasm: Autoimmune disease
Benign and Malignant Lymphomas
Associated Neoplasm: Acanthosis Nigricans
Visceral Malignancy
Associated Neoplasm: Dysplastic Nevus
Malignant Melanoma
Associated Neoplasm: Radiation Exposure
Sarcoma
Associated Tumor: abl
Oncogene or Tumor suppressor?
CML
oncogene
Associated Tumor: c-myc
Oncogene or Tumor suppressor?
Burkitt's lymphoma
Oncogene
Associated Tumor: bcl-2
Oncogene or Tumor suppressor?
Follicular and undifferentiated lymphoma
Oncogene
Associated Tumor: erb-B2
Oncogene or Tumor suppressor?
Breast, ovarian, and gastric carcinoma
Oncogene
Associated Tumor: ras
Oncogene or Tumor suppressor?
colon carcinoma
Oncogene
Associated Tumor: L-myc
Oncogene or Tumor suppressor?
Lung Cancer
Oncogene
Associated Tumor: N-myc
Oncogene or Tumor suppressor?
Neuroblastoma
Oncogene
Associated Tumor: ret
Oncogene or Tumor suppressor?
MEN II and III
Oncogene
Associated Tumor: c-kit
Oncogene or Tumor suppressor?
Gastrointestinal stromal tumor
Oncogene
Associated Tumor: Rb
Oncogene or Tumor Suppressor
Retinoblastoma, Osteosarcoma
Tumor Suppressor
Associated Tumor: BRCA1
Oncogene or Tumor Suppressor
Breast and Ovarian Cancer
Tumor Suppressor
Associated Tumor: BRCA2
Oncogene or Tumor Suppressor
Breast
Tumor Suppressor
Associated Tumor: p53
Oncogene or Tumor Suppressor
Most cancers
Tumor Suppressor
Associated Tumor: p16
Oncogene or Tumor Suppressor
Melonoma
Tumor Suppressor
Associated Tumor: APC
Oncogene or Tumor Suppressor
Colorectal Cancer (FAP)
Tumor Suppressor
Associated Tumor: WT1
Oncogene or Tumor Suppressor
Wilm's Tumor
Tumor Suppressor
Associated Tumor: NF1
Oncogene or Tumor Suppressor
Neurofibromatosis Type 1
Tumor Suppressor
Associated Tumor: NF2
Oncogene or Tumor Suppressor
Neurofibromatosis Type 2
Tumor Suppressor
Associated Tumor: DPC
Oncogene or Tumor Suppressor
Pancreatic Cancer
Tumor Suppressor
Associated Tumor: DCC
Oncogene or Tumor Suppressor
Colon Cancer
Tumor Suppressor
Name the Neoplasm: Patient with Cushing's syndrome
ACTH - Small Cell Lung Cancer
Name the Neoplasm: Patient with SIADH
ADH - Small Cell Lung Cancer and Intracranial neoplasms
Name the Neoplasm: Patient with Hypercalcemia
PTH - Squamous Cell Lung Carcinoma, renal cell carcinoma, and Breast Cancer
Name the Neoplasm: Patient with Polycethemia
EPO - Renal Cell Carcinoma, hemangioblastoma
Name the Neoplasm: Patient with Lambert-Eaton Syndrome (progressive weakness w/out facial involvement)
Antibodies against presynaptic Ca2+ channels and NMJ - Thymoma, Small Cell Lung Cancer
Name the Neoplasm: Patient with Gout and/or urate nephropathy
Excessive Nucleic Acids - Leukemias and lymphomas
Psammoma bodies are found in these 4 cancers:
1. Papillary adenocarcinoma of the thyroid
2. Serous papillary cystadenocarcinoma of ovary
3. Meningioma
4. Malignant mesothelioma
PSaMMoma
Associated pathology(s): PSA
Prostate-specific antigen -
Prostate carcinoma
BPH
Prostatitis
Associated pathology(s): Prostatic acid phosphatase
Prostate carcinoma
Associated pathology(s): CEA
Carcinoembryonic antigen - very nonspecific. + in ~70% of colorectal and pancreatic cancers. Also in breast and gastric tumors
Associated pathology(s): a-Fetoprotein
NTDs
Hepatocellular carcinoma
Nonseminomatous germ cell tumor (yolk sac tumor)
DECREASED in Downs Syndrome
Associated pathology(s): BhCG
Hydatidiform moles
Choriocarcinomas
Gestational trophoblastic tumors
Associated pathology(s): CA-125
Ovarian Cancer
Malignant epithelial tumors
Associated pathology(s): S-100
Melanoma
Neural tumors
Astrocytoma
Associated pathology(s): Alkaline phosphatase
Bone Metastases
Obstructive biliary Disease
Paget's disease
Associated pathology(s): Bombesin
Neuroblastoma
Lung and Gastric Cancer
Associated pathology(s): TRAP
Tartrate-resistant acid phophatase.
Hairy cell leukemia
Associated pathology(s): CA-19-9
Pancreatic adenocarcinoma
Affected Enzyme in Pb poisoning
Ferrochelatase and ALA dehydratase
Affected Enzyme in acute intermittent porphyria
Uroporphyrinogen I Synthase
Affected Enzyme in Porphyria cutanea tarda
Uroporphyrinogen decarboxylase
Accumulated substrate in Pb poisoning
Coproporphyrin and ALA
Accumulated substrate in acute intermittent porphyria
Porphobilinogen and delta-ALA
Accumulated substrate in Porphyria cutanea tarda
Uropophyrin
t(9,22)
Philadelphia chromsome - CML (bcr-abl hybrid)
t(8,14)
Burkitt's lymphoma (c-myc)
t(14,18)
Follicular lymphomas (bcl-2)
t(15,17)
M3 type of AML (responsive to all-trans retinoic acid)
t(11,22)
Ewing's sarcoma
t(11,14)
Mantle cell lymphoma
t(8,21)
M2 of AML