Usmle Step 1 First Aid High Yield Principles In Pathology

Front 1

Associated Neoplasm: Down Syndrome

Back 1

ALL, AML

Front 2

Associated Neoplasm: Xeroderma pegmetosum, albinism

Back 2

Melanoma, basal cell carcinoma, and especially squamous cell carcinoma

Front 3

Associated Neoplasm: Chronic atrophic gastritis, pernicious anemia

Back 3

Gastric Adenocarcinoma

Front 4

Associated Neoplasm: Tuberous sclerosis (facial angiofibroma, seizures, mental retardation)

Back 4

Astrocytoma, Angiomyolipoma, and cardiac rhabdomyoma

Front 5

Associated Neoplasm: Actinic keratosis

Back 5

Squamous Cell Carcinoma of skin

Front 6

Associated Neoplasm: Barrett's Esophagus

Back 6

Esophageal Adenocarcinoma

Front 7

Associated Neoplasm: Plummer-Vinson Syndrome (atrophic glossitis, esophageal webs, anemia; all due to Fe def)

Back 7

Squamous Cell Carcinoma of esophagus

Front 8

Associated Neoplasm: Cirrhosis

Back 8

Hepatocellular Carcinoma

Front 9

Associated Neoplasm: Ulcerative Colitis

Back 9

Colonic Adenocarcinoma

Front 10

Associated Neoplasm: Paget's disease of the bone

Back 10

Secondary osteosarcoma
Fibrosarcoma

Front 11

Associated Neoplasm: Immunodeficiency States

Back 11

Malignant Lymphomas

Front 12

Associated Neoplasm: AIDS

Back 12

Aggressive Malignant Lymphoma

Front 13

Associated Neoplasm: Autoimmune disease

Back 13

Benign and Malignant Lymphomas

Front 14

Associated Neoplasm: Acanthosis Nigricans

Back 14

Visceral Malignancy

Front 15

Associated Neoplasm: Dysplastic Nevus

Back 15

Malignant Melanoma

Front 16

Associated Neoplasm: Radiation Exposure

Back 16

Sarcoma

Front 17

Associated Tumor: abl
Oncogene or Tumor suppressor?

Back 17

CML
oncogene

Front 18

Associated Tumor: c-myc
Oncogene or Tumor suppressor?

Back 18

Burkitt's lymphoma
Oncogene

Front 19

Associated Tumor: bcl-2
Oncogene or Tumor suppressor?

Back 19

Follicular and undifferentiated lymphoma
Oncogene

Front 20

Associated Tumor: erb-B2
Oncogene or Tumor suppressor?

Back 20

Breast, ovarian, and gastric carcinoma
Oncogene

Front 21

Associated Tumor: ras
Oncogene or Tumor suppressor?

Back 21

colon carcinoma
Oncogene

Front 22

Associated Tumor: L-myc
Oncogene or Tumor suppressor?

Back 22

Lung Cancer
Oncogene

Front 23

Associated Tumor: N-myc
Oncogene or Tumor suppressor?

Back 23

Neuroblastoma
Oncogene

Front 24

Associated Tumor: ret
Oncogene or Tumor suppressor?

Back 24

MEN II and III
Oncogene

Front 25

Associated Tumor: c-kit
Oncogene or Tumor suppressor?

Back 25

Gastrointestinal stromal tumor
Oncogene

Front 26

Associated Tumor: Rb
Oncogene or Tumor Suppressor

Back 26

Retinoblastoma, Osteosarcoma
Tumor Suppressor

Front 27

Associated Tumor: BRCA1
Oncogene or Tumor Suppressor

Back 27

Breast and Ovarian Cancer
Tumor Suppressor

Front 28

Associated Tumor: BRCA2
Oncogene or Tumor Suppressor

Back 28

Breast
Tumor Suppressor

Front 29

Associated Tumor: p53
Oncogene or Tumor Suppressor

Back 29

Most cancers
Tumor Suppressor

Front 30

Associated Tumor: p16
Oncogene or Tumor Suppressor

Back 30

Melonoma
Tumor Suppressor

Front 31

Associated Tumor: APC
Oncogene or Tumor Suppressor

Back 31

Colorectal Cancer (FAP)
Tumor Suppressor

Front 32

Associated Tumor: WT1
Oncogene or Tumor Suppressor

Back 32

Wilm's Tumor
Tumor Suppressor

Front 33

Associated Tumor: NF1
Oncogene or Tumor Suppressor

Back 33

Neurofibromatosis Type 1
Tumor Suppressor

Front 34

Associated Tumor: NF2
Oncogene or Tumor Suppressor

Back 34

Neurofibromatosis Type 2
Tumor Suppressor

Front 35

Associated Tumor: DPC
Oncogene or Tumor Suppressor

Back 35

Pancreatic Cancer
Tumor Suppressor

Front 36

Associated Tumor: DCC
Oncogene or Tumor Suppressor

Back 36

Colon Cancer
Tumor Suppressor

Front 37

Name the Neoplasm: Patient with Cushing's syndrome

Back 37

ACTH - Small Cell Lung Cancer

Front 38

Name the Neoplasm: Patient with SIADH

Back 38

ADH - Small Cell Lung Cancer and Intracranial neoplasms

Front 39

Name the Neoplasm: Patient with Hypercalcemia

Back 39

PTH - Squamous Cell Lung Carcinoma, renal cell carcinoma, and Breast Cancer

Front 40

Name the Neoplasm: Patient with Polycethemia

Back 40

EPO - Renal Cell Carcinoma, hemangioblastoma

Front 41

Name the Neoplasm: Patient with Lambert-Eaton Syndrome (progressive weakness w/out facial involvement)

Back 41

Antibodies against presynaptic Ca2+ channels and NMJ - Thymoma, Small Cell Lung Cancer

Front 42

Name the Neoplasm: Patient with Gout and/or urate nephropathy

Back 42

Excessive Nucleic Acids - Leukemias and lymphomas

Front 43

Psammoma bodies are found in these 4 cancers:

Back 43

1. Papillary adenocarcinoma of the thyroid
2. Serous papillary cystadenocarcinoma of ovary
3. Meningioma
4. Malignant mesothelioma
PSaMMoma

Front 44

Associated pathology(s): PSA

Back 44

Prostate-specific antigen -
Prostate carcinoma
BPH
Prostatitis

Front 45

Associated pathology(s): Prostatic acid phosphatase

Back 45

Prostate carcinoma

Front 46

Associated pathology(s): CEA

Back 46

Carcinoembryonic antigen - very nonspecific. + in ~70% of colorectal and pancreatic cancers. Also in breast and gastric tumors

Front 47

Associated pathology(s): a-Fetoprotein

Back 47

NTDs
Hepatocellular carcinoma
Nonseminomatous germ cell tumor (yolk sac tumor)
DECREASED in Downs Syndrome

Front 48

Associated pathology(s): BhCG

Back 48

Hydatidiform moles
Choriocarcinomas
Gestational trophoblastic tumors

Front 49

Associated pathology(s): CA-125

Back 49

Ovarian Cancer
Malignant epithelial tumors

Front 50

Associated pathology(s): S-100

Back 50

Melanoma
Neural tumors
Astrocytoma

Front 51

Associated pathology(s): Alkaline phosphatase

Back 51

Bone Metastases
Obstructive biliary Disease
Paget's disease

Front 52

Associated pathology(s): Bombesin

Back 52

Neuroblastoma
Lung and Gastric Cancer

Front 53

Associated pathology(s): TRAP

Back 53

Tartrate-resistant acid phophatase.
Hairy cell leukemia

Front 54

Associated pathology(s): CA-19-9

Back 54

Pancreatic adenocarcinoma

Front 55

Affected Enzyme in Pb poisoning

Back 55

Ferrochelatase and ALA dehydratase

Front 56

Affected Enzyme in acute intermittent porphyria

Back 56

Uroporphyrinogen I Synthase

Front 57

Affected Enzyme in Porphyria cutanea tarda

Back 57

Uroporphyrinogen decarboxylase

Front 58

Accumulated substrate in Pb poisoning

Back 58

Coproporphyrin and ALA

Front 59

Accumulated substrate in acute intermittent porphyria

Back 59

Porphobilinogen and delta-ALA

Front 60

Accumulated substrate in Porphyria cutanea tarda

Back 60

Uropophyrin

Front 61

t(9,22)

Back 61

Philadelphia chromsome - CML (bcr-abl hybrid)

Front 62

t(8,14)

Back 62

Burkitt's lymphoma (c-myc)

Front 63

t(14,18)

Back 63

Follicular lymphomas (bcl-2)

Front 64

t(15,17)

Back 64

M3 type of AML (responsive to all-trans retinoic acid)

Front 65

t(11,22)

Back 65

Ewing's sarcoma

Front 66

t(11,14)

Back 66

Mantle cell lymphoma

Front 67

t(8,21)

Back 67

M2 of AML