Usmle Step 1 Fa Heme/onc-Lymphomas

Front 1

Reid Sternberg cells (cell markers)

Back 1

Tumor giant cells distinctive for hodgkin's lymphoma
Binucleate or bilobed
CD30+ and CD15+
B cell origin

Front 2

Nonspecific lymphadenitis
(a) presentation
(b) cause

Back 2

(a) enlarged, tender LN following
(b) drugs, toxins, infection

Front 3

Causes of monocytosis

Back 3

TB
Endocarditis
Malaria
Brucellosis
Rickettsiosis

Front 4

Lymphocytosis causes

Back 4

TB
Brucellosis
Pertussis
Viral hepatitis
CMV
Infectious mono

Front 5

Eosinophilic leukocytosis causes

Back 5

Neoplasms
Allergy
Asthma
Collagen vascular diseases
Parasitic infection
Skin rashes

Front 6

Follicular hyperplasia
(a) describe
(b) cause
(c) etiologies

Back 6

(a) large germinal centers, containing mostly B cells, helper T cells, histiocytes
(b) B cell antibody response
(c) bacterial infection, exposure to new antigen

Front 7

Paracortical hyperplasia
(a) describe
(b) cause
(c) etiologies

Back 7

(a) reactive changes
(b) T cell rxn
(c) seen w/phenytoin use, viral infections, or secondary immune response

Front 8

Sinus histiocytosis
(a) describe
(b) cause

Back 8

Lymphatic sinusoids prominent and distended w/macs
Seen in nodes draining carcinoma or any chronic inflammation

Front 9

4 types of hodgkin's lymphoma

Back 9

Nodular sclerosing
Mixed cellularity
Lymphocyte predominant
Lymphocyte depleted

Front 10

Nodular sclerosing hodgkin's lymphoma
(a) RS cells
(b) lymphocyte
(c) prognosis
(d) comments

Back 10

(a) RS cells: +
(b) lymphocyte: +++
(c) prognosis: excellent
(d) comments: collagen banding; F>M; primarily young adults

Front 11

Mixed cellularity hodgkin's lymphoma
(a) RS cells
(b) lymphocyte
(c) prognosis
(d) comments

Back 11

(a) RS cells: ++++
(b) lymphocyte: +++
(c) prognosis: intermediate
(d) comments: lots of RS cells

Front 12

Lymphocyte predominant hodgkin's lymphoma
(a) RS cells
(b) lymphocyte
(c) prognosis
(d) comments

Back 12

(a) RS cells: +
(b) lymphocyte: ++++
(c) prognosis: excellent
(d) comments: <25YO M

Front 13

Lymphocyte depleted hodgkin's lymphoma
(a) RS cells
(b) lymphocyte
(c) prognosis
(d) comments

Back 13

(a) RS cells: RS high relative to lymphocytes
(b) lymphocyte: +
(c) prognosis: poor
(d) comments: older males with disseminated disease

Front 14

Most important factor in prognosis for hodgkins lymphoma

Back 14

Stage

Front 15

Small lymphocytic lymphoma (NHL)
(a) age
(b) cell type
(c) genetics
(d) presentation

Back 15

(a) age: adults
(b) cell type: B cells
(c) genetics: n/a
(d) presentation: like CLL w/focal mass; low grade

Front 16

Follicular lymphoma (small cleaved cell)
(a) age
(b) cell type
(c) genetics
(d) presentation

Back 16

(a) age: adults
(b) cell type: B cells
(c) genetics: t(14;18) bcl-2
(d) presentation: difficult to cure; indolent course

Front 17

Diffuse large cell lymphoma
(a) age
(b) cell type
(c) genetics
(d) presentation

Back 17

(a) age: usually older adults; 20% in children
(b) cell type: 80% B, 20% T (mature)
(c) genetics: n/a
(d) presentation: aggressive, but many are curable

Front 18

Mantle cell lymphoma
(a) age
(b) cell type
(c) genetics
(d) presentation

Back 18

(a) age: adults
(b) cell type: B cells
(c) genetics: t(11;14)
(d) presentation: poor prognosis, CD5+

Front 19

Lymphoblastic lymphoma
(a) age
(b) cell type
(c) genetics
(d) presentation

Back 19

(a) age: usually children
(b) cell type: immature T cells
(c) genetics: n/a
(d) presentation: mediastinal mass common

Front 20

Burkitt's lymphoma
(a) age
(b) cell type
(c) genetics
(d) presentation

Back 20

(a) age: mostly children
(b) cell type: B cell
(c) genetics: t (8; 14) c myc
(d) presentation: "starry sky" (lymphocytes w/interspersed macs); assoc w/EBV; jaw lesion common in endemic; pelvis or GI common in sporadic

Front 21

Translocation in CML

Back 21

t(9;22) BCR-ABL (philadelphia chromosome)

Front 22

Translocation in Burkitt's lymphoma

Back 22

t(8;14) c-myc activation

Front 23

Translocation in Follicular lymphoma

Back 23

t(14;18) bcl-2 activation

Front 24

Translocation in M3 type AML

Back 24

t(15;17)

Front 25

Translocation in Ewing's sarcoma

Back 25

t(11;22)

Front 26

Translocation in mantle cell lymphoma

Back 26

t(11;14)

Front 27

Mycosis fungoides
(a) presentation
(b) cell type

Back 27

(a) skin lymphoma; inflammation, plaque, tumor can occur
(b) neoplastic T cell infiltrates in the dermis

Front 28

Sezary syndrome
(a) presentation
(b) cell type

Back 28

(a) pruritic erythroderma, exfoliation, lymphadenopathy
(b) "sezary cells" T cells with cerebriform nuclei (same as mycosis fungoides)