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21 Cards in this Set
- Front
- Back
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furosemide
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sulfonamide loop dieuretic
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what does a sulfonamide loop dieuretic do?
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inhibits (Na+ , K+, 2cl-) of thick ascending loop of hele
abolishies hypertonicity of medulla prevent concentrate of urine increased calcium exxcretion(b/c dependent on gradient which not there anymore) |
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use of sulfonamide loop dieuretic furosemide?
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edematous state (CHF, Cirrhosis, nephrotic syndrome, pulmonary edema), hypertension, hypercalcemia
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tox of furosemide
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hypokalemia, ototox, dehydration, allergy(sulfa), nephritis(interstitial), gout
OH DANG! |
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mannitol
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osmotic dieuteic
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what does mannitol do?
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increases tubular fluid osmolarity, produing an increase urine flow
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causes shock, drug overdose, decreased intracranial/intraocular pressure
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mannitol
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pulmonary edema, dehydration.
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maniitol tox
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mannitol contraindicated in
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anuria (inability to urinate) and CHF
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used to treat breast cancer and useful to prevent osteoporosis
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tamoxifen, raloxifene
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which one tamoxiene and raloxifene increases risk of endomerail carcinoma via partial agonist effects
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tamoxifen
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tamoxifen other side efects-
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besdies endometrial carcinoma risk - hot flashes
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why doesnt raloxifene cause an increase risk for endometerial carcinoma
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b/c it is an endometrial antagonist
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tamoxifen, raloxifene MOA
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receptor antagonists in breast , agonist in bone, block binding of estrogen to estrogen receptor-positive cells
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sildenafil,vardenafil MOA
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inhibits cGMP phosphodiesterase, causing and increase in cGMP smooth muscle relaxation in corpus cavernosum
increaseing blood flow and a penile erection |
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headache flushing dyspepsia, blue-green color vision
risk of life threatening hypotension in patients taking nitrates |
sildenafil,vardenafil
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sildenafil,vardenafil clinical use
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treatment of erectile dysfunction
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phenytoin MOA
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use-dependent blockade of NA+ channels, inhibition of glutamate release from excitatory presynaptic neuron
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clinical use of phenytoin
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tonic-clonic sezuires also a class IB antiarrythmic
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nystagmus,ataxia,diplopia,sedation,SLE-like syndrome, induction of cytochrome P-450.
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phenytoin tox
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chronic use causes gingival hyperplasia in childern
peripheral neuropathy hirsutism megaloblastic anemia(decreased folate asorption) and malignant hyperthermia(rare) teratogenic (fetal hydantoin syndrome |
phenytoin chronic tox
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