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21 Cards in this Set

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  • Back
sulfonamide loop dieuretic
what does a sulfonamide loop dieuretic do?
inhibits (Na+ , K+, 2cl-) of thick ascending loop of hele
abolishies hypertonicity of medulla
prevent concentrate of urine
increased calcium exxcretion(b/c dependent on gradient which not there anymore)
use of sulfonamide loop dieuretic furosemide?
edematous state (CHF, Cirrhosis, nephrotic syndrome, pulmonary edema), hypertension, hypercalcemia
tox of furosemide
hypokalemia, ototox, dehydration, allergy(sulfa), nephritis(interstitial), gout
osmotic dieuteic
what does mannitol do?
increases tubular fluid osmolarity, produing an increase urine flow
causes shock, drug overdose, decreased intracranial/intraocular pressure
pulmonary edema, dehydration.
maniitol tox
mannitol contraindicated in
anuria (inability to urinate) and CHF
used to treat breast cancer and useful to prevent osteoporosis
tamoxifen, raloxifene
which one tamoxiene and raloxifene increases risk of endomerail carcinoma via partial agonist effects
tamoxifen other side efects-
besdies endometrial carcinoma risk - hot flashes
why doesnt raloxifene cause an increase risk for endometerial carcinoma
b/c it is an endometrial antagonist
tamoxifen, raloxifene MOA
receptor antagonists in breast , agonist in bone, block binding of estrogen to estrogen receptor-positive cells
sildenafil,vardenafil MOA
inhibits cGMP phosphodiesterase, causing and increase in cGMP smooth muscle relaxation in corpus cavernosum
increaseing blood flow and a penile erection
headache flushing dyspepsia, blue-green color vision
risk of life threatening hypotension in patients taking nitrates
sildenafil,vardenafil clinical use
treatment of erectile dysfunction
phenytoin MOA
use-dependent blockade of NA+ channels, inhibition of glutamate release from excitatory presynaptic neuron
clinical use of phenytoin
tonic-clonic sezuires also a class IB antiarrythmic
nystagmus,ataxia,diplopia,sedation,SLE-like syndrome, induction of cytochrome P-450.
phenytoin tox
chronic use causes gingival hyperplasia in childern
peripheral neuropathy
megaloblastic anemia(decreased folate asorption) and malignant hyperthermia(rare) teratogenic (fetal hydantoin syndrome
phenytoin chronic tox