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82 Cards in this Set
- Front
- Back
what branch of the immune system is acquired in response to an Ag
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adaptive branch
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t or f
t cells can recognize, bind, and internalize unprocessed Ags |
flase
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what type of hypersensitivity is a result of high circulating levels of soluble immune complexes made up of IgG or IgM abs
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type III
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at what stage of b cell development can IgM or IgD be expressed on the cell surface
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mature b cells
the memory cell can have IgG, IgA, or IgE |
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what t cell deficiency syndrome is assoc w/ facial anomalies, hypoparathyroidism, thymic hypoplasia, and recurrent viral and fungal infections
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Digeorges
3rd and 4th pharyngeal pouches t cells do intracellular infections b cells do extracellular |
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what is the stimulus for the classical pathway activation
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ag-ab complexes
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what is the first membrane bound Ig on B cell membranes
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IgM; then IgD
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what region of the Ig does not change with class switching
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hypervariable region
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in MHC II molecules, what chain blocks accss to the peptide-binding groove during transportation within the cell, ensuring that the MHC II peptide complex is transported to the surface
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invariant chain
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what chromosome codes for HLA gene products
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6p
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what cells are atypical on a peripheral blood smear in heterophil pos mono
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T cells
(the B cells are infected) |
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what is the major Ig of the secondary immune response in the mucosal barriers
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IgA
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what AR disorders is seen by age 1 to 2 with recurrent sinopulmonary infections, uncoordinated mm mov't, and dilation of the blood vessels
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ataxia-telangiectasia
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what are teh four chemotactic agents
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C3a
LB4 IL-8 bacterial peptides |
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what subset of CD4 helper T cells stimulate B cell division and differentiation
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Th2
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which region of the variable domain comprises the Ag0binding site of the Ab
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hypervariable region
3 per light chain 3 per heavy chain |
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t or f
the inc oxygen consumption after phagocytosis is for ATP production |
f- its for toxic metabolites
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what is the limited portion of a large Ag that will actually be recognized and bound to an Ab and that contains approximately five to six amino acids or four to five hexose units
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antigenic determinant (epitope)
idiotypes bind epitopes |
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what complement factor or factors are assoc w/
1. chemotaxis 2. MAC 3. opsonization 4. anaphylaxis |
1. C5a
2. C5b6789 3. C3b 4. C3a, C4a, C5a |
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what happens to the Ab specificty when class switching occurs in mature B cells
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as the isotype is swithced, the Ab specificity does not change because it does not affect the variable chains
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what IL down regulates CMI
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IL-10
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name the type of graft described by these transplants
1. from one site to another on the same person 2. between genetically identical individuals 3. from on person to the next 4. from on spp to another |
1. autograft
2. isograft 3. allograft 4. xenograft |
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what is the name of the process in which cells migrate toward an attractant along a conc gradient
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chemotaxis
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what are the two functions of the thymus in T cell diff
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hormone secretion for T cell differentiation
T cell education to recognize self from nonself |
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what is the name of the t cell rich area of the lymph node
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paracortex
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what cell surface marker do all T cells have
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CD3
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t or f
patients with common variable hypogannaglobinemia have B cells in the peripheral blood |
true
- it firsts appears in the 20s and is assoc w/ a gradual dec in Ig levels over time |
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what is the Ig assoc with the primary immune response
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IgM
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what MHC class of antigens do all nucleated cells carry
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MHC I
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what Ig is responsible for activation of complement, opsonizatin, and ADCC, and is actively transported across the placenta
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IgG
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what type of Ag do T cells recognize
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processed
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what Ig is the major protective factor in colustrum
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IgA
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what is the second cell involved in the immune response
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CD4 cell
(APC is the first) |
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what is the term for thymic induction of T cells with high-affinity Ag receptors for self that are programmed to undergo apoptosis
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negative selection
-helps prevent autoimmune diseases |
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what five main oxidizing rax are used to kill ingested organisms
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1. H2O2
2. superoxide 3. hydroxyl radical 4. mycloperoxidase 5. hypochlorous acid |
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what Ig is assoc w/ ADCC for parasite
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IgE
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t or f
rbc's do not have MHC I |
t
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what Ig is assoc w/ mast cell and basophil binding
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IgE
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what IL do t cells secrete to induce T and b cell division
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IL2
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development of what t cell line follows low affinity for self-MHC II Ags in the thymus
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CD4 T cells
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what is the term for a substance secreted by a leukocyte in response to an stimulus
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cytokine
if it affects another class of leukocytes its an interleukin |
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what subset of CD4 t cells is responslble for mast cell and eosinophil precurosor proliferation
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Th2 cells
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what are the four major functions of the acquried immune system
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recognize self from nonself
amplify via cell division or complementation control the level of response remove foreign material |
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what endotoxin receptor is the best marker for macrophages
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CD14
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what is the term for the inherent ability to induce a specific immune response
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immunogenicity
antigenicity refers to ab/lymphocyte reax to a specficic substances |
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what molecule differentiats teh MHC I from II ag
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the beta 2 microglobulin on class I
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what b cell disorder is characterized by pre-B cells in the bone marrow, no circulating B cells im plasma, nl cell CMI, low Igs, and appearance by 6 mo old
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bruton x-lined hypogammaglobulinemia
tyrosine kinase def leads to inadequate B cell maturation |
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what subtype of IgG does not bind to staph A protein
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IgG3
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what mast cell mediator is a chemotactic agent
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eosinophil chemotactic factor A
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what is the major Ig of the secondary immune response
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IgG
|
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what T cell surface projection recognizes foreign and reacts to foreign Ags (presented by APCs)
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TCR
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what is the confirmatory HIV test
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Western blot
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what is the name of the major chemotactic agent released from
1. neutrophils 2. macrophages 3. blood serum 4. bacteria |
1. LTB4
2. IL8 (and IL1 and TNF-g) 3. C5a 4. F-met-peptides |
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what cell surface marker is found on blood B cells
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CD19
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what is the name of the B cell rich area in the lymph node
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primary follicle of cortex
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what are the four ways to down regulate the immune system
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1. dec Ag levels
2. IgG in high conc 3. inhibit B cells w/ Ag bound to IgG 4. turn of the original T or B cell with anti-Ab |
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what is the only Ig that crosses the placenta
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IgG
|
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what is given to prenant women within 24 hrs after birth to eliminate fetal blood Rh= cells from their circulation
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Rho (D) immune globulin (RhoGAM)
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what iL is essential for lymphoid cell development
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IL7
(a 7 upside down is an L) |
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what type of cell can never leave the lymph node
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plasma cell
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via what pathway is glycolysis inc after phagocytosis
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HMP shunt
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what is the term for a delay in the onset of nl IgG synthesis seen in the fifth to sixth month of life
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transient hypogammagloniemia of infancy
usually resolves by 16 to 30 mo |
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what subset of CD4 helper T cell function is helping the development of CD8 cells
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TH1
(also responsible for type IV hypersensitivity) |
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what is the term for the strength of the assoc between Ags and Abs
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avidity
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what type of Ag do b cells recognize
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free, unprocessed Ag
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what Ig is assoc w/ Ag recognition receptor on the surface of mature b cells
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IgM and IgG
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which chr is assoc w/ MHC genes
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6
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what is the term for processing an APCs pinocytosed material by fusing with a lysosomal granule and cleaving the Ag into peptide fragments
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Ag processing- needed for class I molecules
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what is the most common precipitin test used in clinical medicine
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Radial ImmunoDiffusion (RID)
for Ig levels |
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what Ig activates the complement cascade most efficienctly
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IgM
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what assay is used to identify MHC I molecules
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microcytotoxic assay
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which IL inc IgA synthesis
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IL-5 (also stimulates eosinophil proliferation)
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what is the term for an immunogenic agent that is too small to elicit an immune response
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hapten
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what type II hyersensitivity disorder has...
1. autoAbs against ACh receptors 2. autoAbs aginst platelet integrin 3. autoAbs against type IV collaged of kidneys and lungs 4. autoAbs against TSH receptor 5. autoAbs against RBC AgI |
1. myasthenia gravis
2. autoimmune thrombocytopenia purpura 3. Goodpastures 4. grave's 5. autoimmune hemolytic anemia |
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what Ig activates the alternate pathway, neutralizes bacterial endotoxins and viruses, and prevents bacterial adherence
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IgA
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what enzyme is deficient in patients with CGD
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NADPH oxidase
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what subtype of IgG does not activate complement
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IgG4
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what two cell lines of the immune system do not belong to the innate branch
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T and B cells- are in adaptive branch
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what subset of T cells recognizes the MHC class II ags
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CD4 t cells
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what T cell line arises from low affinity for self-MHC class I ag's in thymus
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CD8 t cells
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what MHC class functions as a target for elimination of abnormal host cells
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MHC class I ags (endogenous pathway)
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what are the three plymorphonuclear leukocytes
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neutrophils
eosinophils basophils |