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82 Cards in this Set

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  • Back
what branch of the immune system is acquired in response to an Ag
adaptive branch
t or f
t cells can recognize, bind, and internalize unprocessed Ags
flase
what type of hypersensitivity is a result of high circulating levels of soluble immune complexes made up of IgG or IgM abs
type III
at what stage of b cell development can IgM or IgD be expressed on the cell surface
mature b cells
the memory cell can have IgG, IgA, or IgE
what t cell deficiency syndrome is assoc w/ facial anomalies, hypoparathyroidism, thymic hypoplasia, and recurrent viral and fungal infections
Digeorges
3rd and 4th pharyngeal pouches

t cells do intracellular infections
b cells do extracellular
what is the stimulus for the classical pathway activation
ag-ab complexes
what is the first membrane bound Ig on B cell membranes
IgM; then IgD
what region of the Ig does not change with class switching
hypervariable region
in MHC II molecules, what chain blocks accss to the peptide-binding groove during transportation within the cell, ensuring that the MHC II peptide complex is transported to the surface
invariant chain
what chromosome codes for HLA gene products
6p
what cells are atypical on a peripheral blood smear in heterophil pos mono
T cells
(the B cells are infected)
what is the major Ig of the secondary immune response in the mucosal barriers
IgA
what AR disorders is seen by age 1 to 2 with recurrent sinopulmonary infections, uncoordinated mm mov't, and dilation of the blood vessels
ataxia-telangiectasia
what are teh four chemotactic agents
C3a
LB4
IL-8
bacterial peptides
what subset of CD4 helper T cells stimulate B cell division and differentiation
Th2
which region of the variable domain comprises the Ag0binding site of the Ab
hypervariable region
3 per light chain
3 per heavy chain
t or f
the inc oxygen consumption after phagocytosis is for ATP production
f- its for toxic metabolites
what is the limited portion of a large Ag that will actually be recognized and bound to an Ab and that contains approximately five to six amino acids or four to five hexose units
antigenic determinant (epitope)
idiotypes bind epitopes
what complement factor or factors are assoc w/
1. chemotaxis
2. MAC
3. opsonization
4. anaphylaxis
1. C5a
2. C5b6789
3. C3b
4. C3a, C4a, C5a
what happens to the Ab specificty when class switching occurs in mature B cells
as the isotype is swithced, the Ab specificity does not change because it does not affect the variable chains
what IL down regulates CMI
IL-10
name the type of graft described by these transplants
1. from one site to another on the same person
2. between genetically identical individuals
3. from on person to the next
4. from on spp to another
1. autograft
2. isograft
3. allograft
4. xenograft
what is the name of the process in which cells migrate toward an attractant along a conc gradient
chemotaxis
what are the two functions of the thymus in T cell diff
hormone secretion for T cell differentiation
T cell education to recognize self from nonself
what is the name of the t cell rich area of the lymph node
paracortex
what cell surface marker do all T cells have
CD3
t or f
patients with common variable hypogannaglobinemia have B cells in the peripheral blood
true
- it firsts appears in the 20s and is assoc w/ a gradual dec in Ig levels over time
what is the Ig assoc with the primary immune response
IgM
what MHC class of antigens do all nucleated cells carry
MHC I
what Ig is responsible for activation of complement, opsonizatin, and ADCC, and is actively transported across the placenta
IgG
what type of Ag do T cells recognize
processed
what Ig is the major protective factor in colustrum
IgA
what is the second cell involved in the immune response
CD4 cell
(APC is the first)
what is the term for thymic induction of T cells with high-affinity Ag receptors for self that are programmed to undergo apoptosis
negative selection
-helps prevent autoimmune diseases
what five main oxidizing rax are used to kill ingested organisms
1. H2O2
2. superoxide
3. hydroxyl radical
4. mycloperoxidase
5. hypochlorous acid
what Ig is assoc w/ ADCC for parasite
IgE
t or f
rbc's do not have MHC I
t
what Ig is assoc w/ mast cell and basophil binding
IgE
what IL do t cells secrete to induce T and b cell division
IL2
development of what t cell line follows low affinity for self-MHC II Ags in the thymus
CD4 T cells
what is the term for a substance secreted by a leukocyte in response to an stimulus
cytokine
if it affects another class of leukocytes its an interleukin
what subset of CD4 t cells is responslble for mast cell and eosinophil precurosor proliferation
Th2 cells
what are the four major functions of the acquried immune system
recognize self from nonself
amplify via cell division or complementation
control the level of response
remove foreign material
what endotoxin receptor is the best marker for macrophages
CD14
what is the term for the inherent ability to induce a specific immune response
immunogenicity
antigenicity refers to ab/lymphocyte reax to a specficic substances
what molecule differentiats teh MHC I from II ag
the beta 2 microglobulin on class I
what b cell disorder is characterized by pre-B cells in the bone marrow, no circulating B cells im plasma, nl cell CMI, low Igs, and appearance by 6 mo old
bruton x-lined hypogammaglobulinemia
tyrosine kinase def leads to inadequate B cell maturation
what subtype of IgG does not bind to staph A protein
IgG3
what mast cell mediator is a chemotactic agent
eosinophil chemotactic factor A
what is the major Ig of the secondary immune response
IgG
what T cell surface projection recognizes foreign and reacts to foreign Ags (presented by APCs)
TCR
what is the confirmatory HIV test
Western blot
what is the name of the major chemotactic agent released from
1. neutrophils
2. macrophages
3. blood serum
4. bacteria
1. LTB4
2. IL8 (and IL1 and TNF-g)
3. C5a
4. F-met-peptides
what cell surface marker is found on blood B cells
CD19
what is the name of the B cell rich area in the lymph node
primary follicle of cortex
what are the four ways to down regulate the immune system
1. dec Ag levels
2. IgG in high conc
3. inhibit B cells w/ Ag bound to IgG
4. turn of the original T or B cell with anti-Ab
what is the only Ig that crosses the placenta
IgG
what is given to prenant women within 24 hrs after birth to eliminate fetal blood Rh= cells from their circulation
Rho (D) immune globulin (RhoGAM)
what iL is essential for lymphoid cell development
IL7
(a 7 upside down is an L)
what type of cell can never leave the lymph node
plasma cell
via what pathway is glycolysis inc after phagocytosis
HMP shunt
what is the term for a delay in the onset of nl IgG synthesis seen in the fifth to sixth month of life
transient hypogammagloniemia of infancy
usually resolves by 16 to 30 mo
what subset of CD4 helper T cell function is helping the development of CD8 cells
TH1
(also responsible for type IV hypersensitivity)
what is the term for the strength of the assoc between Ags and Abs
avidity
what type of Ag do b cells recognize
free, unprocessed Ag
what Ig is assoc w/ Ag recognition receptor on the surface of mature b cells
IgM and IgG
which chr is assoc w/ MHC genes
6
what is the term for processing an APCs pinocytosed material by fusing with a lysosomal granule and cleaving the Ag into peptide fragments
Ag processing- needed for class I molecules
what is the most common precipitin test used in clinical medicine
Radial ImmunoDiffusion (RID)
for Ig levels
what Ig activates the complement cascade most efficienctly
IgM
what assay is used to identify MHC I molecules
microcytotoxic assay
which IL inc IgA synthesis
IL-5 (also stimulates eosinophil proliferation)
what is the term for an immunogenic agent that is too small to elicit an immune response
hapten
what type II hyersensitivity disorder has...
1. autoAbs against ACh receptors
2. autoAbs aginst platelet integrin
3. autoAbs against type IV collaged of kidneys and lungs
4. autoAbs against TSH receptor
5. autoAbs against RBC AgI
1. myasthenia gravis
2. autoimmune thrombocytopenia purpura
3. Goodpastures
4. grave's
5. autoimmune hemolytic anemia
what Ig activates the alternate pathway, neutralizes bacterial endotoxins and viruses, and prevents bacterial adherence
IgA
what enzyme is deficient in patients with CGD
NADPH oxidase
what subtype of IgG does not activate complement
IgG4
what two cell lines of the immune system do not belong to the innate branch
T and B cells- are in adaptive branch
what subset of T cells recognizes the MHC class II ags
CD4 t cells
what T cell line arises from low affinity for self-MHC class I ag's in thymus
CD8 t cells
what MHC class functions as a target for elimination of abnormal host cells
MHC class I ags (endogenous pathway)
what are the three plymorphonuclear leukocytes
neutrophils
eosinophils
basophils