Usmle Highly Tested Topics - Ans Pharm

Front 1

Epinephrine

Back 1

1. α1, α2, β1, β2

Front 2

Norepinephrine

Back 2

2. α1, α2, β1 (no β2 activity)

Front 3

GABA

Back 3

3. Causes an inhibitory cell hyperpolarization

Front 4

Muscarinic-r

Back 4

4. Uses DAG & IP3 as 2nd messengers 5. Parasympathetic control

Front 5

Bethanechol

Back 5

6. Cholinergic. increases GI & Bladder motility. Txt atonic bladder post-op

Front 6

Pilocarpine

Back 6

7. Cholinergic. Pupillary constriciton= miosis. Ciliary constriction= accomodation. 8. Txt acute glaucoma

Front 7

Isoflurophate

Back 7

9. Organophosphate. Irreversible acetylcholinesterase (-)r

Front 8

Pralidoxime

Back 8

10. “2PAM”. Reverses organophosphate binding to acetylcholinesterase

Front 9

Neostigmine

Back 9

11. Reversible acetylcholinesterase (-)r 12. Txt Myasthenia Gravis

Front 10

Myasthenia Gravis

Back 10

13. Anitbodies to Ach-r. increases ’g muscular weakness due to Ach’s weak postsynaptic effect @ NMJ. Inactivates-r

Front 11

Tubocurium

Back 11

14. Nondepol. Competitive cholinergic N-r (-)r. 15. Prevents Ach binding but does not activate NMJ 16. increases Histamine release= decreases BP & increases bronchospasm

Front 12

Trimethaphan

Back 12

17. Nonselectively binds N-r of the PS- and SNS

Front 13

Pancurium

Back 13

18. More potent than tubocurium w/o histamine release

Front 14

Succinylcholine

Back 14

19. Depol. Non competitive (-)r of muscle aciton 20. Opens Na Ch.= fasciculations. Closes Na Ch.= paralysis. Continuous infusion.

Front 15

α1 & Eye

Back 15

21. Mydriasis due to norepinephrine. Prazosin (-).

Front 16

M-r & Eye

Back 16

22. Miosis due to Ach. Atropine (-).

Front 17

Sympathetic

Back 17

23. Post ganglionic symapthetic fibers releases norepinephrine

Front 18

Parasym.

Back 18

24. Post ganglionic parasympathetic fibers release Ach

Front 19

M3-r & Eye

Back 19

25. Contracts sphincter = miosis. Contracts ciliary = accomodation.

Front 20

M2-r & Heart

Back 20

26. Negative chronotropy: decreases HR = vagal arrest 27. Negative inotropy: decreases contractility

Front 21

M3-r & Lung

Back 21

28. Bronchospasm increases secretions

Front 22

M3-r & GI

Back 22

29. increases motility (cramps & diarrhea). Involuntary defecation

Front 23

Tacrine

Back 23

30. Acetylcholine esterase (-)r. Txt Alzheimer’s

Front 24

Atropine

Back 24

31. DOC w/ vagal arrest

Front 25

Glycoperrolate

Back 25

32. M-r(-). Antispasmodic. Txt peptic ulcers.

Front 26

Pirenzepine

Back 26

33. M-r(-). Antispasmodic. Txt peptic ulcers.

Front 27

Doxacurium

Back 27

34. Most potent competitive non-depol NMJ (-)r. No cardiovascular side effects. No Histamine release.

Front 28

β bungarotoxin

Back 28

35. Prevent the releasal of Ach from vesicles @ the pre synaptic nerve ending

Front 29

α bungarotoxin

Back 29

36. Irreversible N-r (-)r = decreases action potentials

Front 30

α1 & Eye

Back 30

37. Contracts radial muscle = mydriasis (pupil dilation)

Front 31

α1 & Arterioles

Back 31

38. Constiction: increases TPR = increases Diastolic pressure = increases Afterload

Front 32

α1 & Venules

Back 32

39. Constriction: increases Venous return = increases Preload

Front 33

α1 & Sex Function

Back 33

40. Ejaculation

Front 34

increases Diastolic

Back 34

41. increases α1 = increases TPR

Front 35

decreases Diastolic

Back 35

42. increases β2; Direct acting vasodilators; (+)Cholinergics

Front 36

β1 & Heart

Back 36

43. (+)chronotropism = increases HR. 44. (+)inotropism = increases contractility; increases SV; increases CO; increases O2 consumption. 45. increases conduction velocity

Front 37

Phenylephrine

Back 37

46. α1 (+) Nasal decongestant.

Front 38

β2(+) Asma Drugs

Back 38

47. Metaproterenol; Albuterol; Terbutaline; Ritodrine; Salmeterol

Front 39

Ritodrine/Turbutaline

Back 39

48. Relaxes myometrium used in pre-mature labor pains

Front 40

Phentolamine

Back 40

49. Epi reversal. Blocks α, vasodilation occurs. Pt goes from HyperTN to HypoTN. 50. Txt pheochromocytoma = decreases BP

Front 41

Terazosin

Back 41

51. Txt BPH

Front 42

Yohimbine

Back 42

52. increases sympathetic outflow = α2 (-). Txt impotence.

Front 43

Cardioselective NMJ

Back 43

53. Pancuronium = increases HR due to atropine-like anti muscarinic vagolytic effect & Gallamine (-)r

Front 44

Ecothiophate

Back 44

54. Irreversible cholinesterase (-)r.

Front 45

Pyridostigmine

Back 45

55. Cholinomimetic that increases s M & N-r effects. (-) acetylcholinesterase & plasma cholinesterase 56. DOC for the oral Txt of MG