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11 Cards in this Set
- Front
- Back
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IL-1
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Secreted by macrophages
Associated with acute inflammation, induces chemokine production to recruit PMN, activates endothelium Endogenous Pyrogen |
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IL-2
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Secreted by CD4+ T cells
Stimulates growth of cytotoxic and helper T cells |
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IL-3
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Secreted by activated T cells
Supports growth and differentiation of bone marrow stem cells; functions similar to GM-CSF |
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IL-4
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Secreted by Th2 cells
Promotes growth of B cells Enhances class switching to IgE and IgG |
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IL-5
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Secreted by Th2 cells
Promotes differentiation of B cells, nhances class switching to IgA Stimulates production and activation of eosinophils |
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IL-6
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Secreted by CD4+ T cells
Stimulates production of acute-phase reactants and immunoglobulins |
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IL-8
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Secreted by macrophages
Major chemotactic factor for neutrophils |
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IL-10
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Secreted by regulatory T cells
Inhibits actions of activated T cells Activates Th2, inhibits Th1 |
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IL-12
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Secreted by B cells and macrophages
Activates NK and Th1 cells |
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IFNγ
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Secreted by Th1 cells
Stimulates macrophages Activates Th1, inhibits Th2 |
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TNFα
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Secreted by macrophages
Mediates septic shock |
