Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
|
"lumpy bumpy" type III hypersensitivity:
ab bind extrinsic ag which are planted in the glomerulus = immune complex OR circulating immune complexes deposit in the glomerulus -> complement activation (classical complement) detected w anti-IgG and anti-C3 |
|
|
linear pattern of type II hypersensitivity;
ab binds intrinsic ag (normal component of glomerulus) anti-IgG and anti-C3 used to detect presence |
|
|
Titers in poststreptococcal glomerulonephritis patients
|
Elevated titers against strep antigen (ASO), low serum C3 levels (C4 can be low or normal)
|
|
|
Renal biopsy in poststreptococcal glomerulonephritis patients
|
hypercellular glomeruli
|
|
|
poststreptococcal glomerulonephritis
|
Type III hypersensitivity; ab against strep ag are cationic, bind to anionic GBM
SUBEPITHELIAL immune complex humps on electron microscopy |
|
|
Renal biopsy in poststreptococcal glomerulonephritis patients
|
hypercellular glomeruli
|
|
|
poststreptococcal glomerulonephritis
|
Type III hypersensitivity; ab against strep ag are cationic, bind to anionic GBM
SUBEPITHELIAL immune complex humps on electron microscopy |
|
|
Goodpastures syndrome
|
anti-GBM Igg cross reacts w alveolar basement membrane
clinical picture of renal failure w/ pulmonary hemorrhage |
|
|
Rapidly progressice crescentric glomerulonephritis
|
Crescent moon shape; consits of fibrin and polasma proteins with glomerular parietal cells, monocytes, and macrophages.
1. Goodpastures syndrome (type II hypersensitivity; antibodies to GBM -> linear IF) 2. Wegener's granulomatosis (c-CNA) 3. Microscopic polyarteritis (p-ANCA) |
|
|
rapidly progressive glomerulonephritis
|
a nephritic syndrome where proliferation of parietal epithelial cells lining Bowman capsule and infiltrating monocytes/macrophages cause formation of glomerular crescents.
|
|
|
Membranous glomerulonephritis
|
mcc of adult nephrotic syndrome;caused by immune response to self antigen (drugs, infections, SLE, solid tumors) or Type II immune response to intrinsic renal antigen
diffuse capillary and GBM thickening; EM "spikes and dome" apperance with subepithelial deposits IF- granular |
