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172 Cards in this Set

  • Front
  • Back

platyhelminthes (trematodes)

flattened dorsoventrally

Schistosomes

 hermaphroditic except for the _______, which have separate sexes

Heterophyes heterophyes


Fasciolopsis buski

mature worms vary in length from less than 2 mm (______) to 75 mm (_______)


oral sucker


ventral sucker

two suckers or attachment organs

oral sucker

anterior; surrounds the mouth

ventral sucker

posterior on the ventral surface

trematodes

leaf-shaped

Diastomiasis

infection with flukes

fresh water

complete their life cycles in ______ and require one or more intermediate hosts

miracidium

(larva in eggs)


is infective to the first intermediate host, usually specific mollusks (snail or clam); covered with cilia

cercaria

larva in 1st intermediate host


may penetrate the vertebrate host or enters a 2nd intermediate host

metacercaria

(in 2nd intermediate host)


is infective to the vertebrate host usually through ingestion  body is covered with a resistant cuticle, which may be smooth or spiny


vitellaria

a series of glandular structures called _______, produce the shell material (vitelline ducts lead inward to the region of the ovary where the shell is formed over the ovum)

uterus

winds forward to the genital pore; it is the largest organ in the body of most trematodes filled with thousands of eggs

trematodes

eggs have a smooth, hard shell that is transparent and generally brown or yellow-brown

operculum

most eggs gave an ____, an “escape hatch” through which the miracidium emerges

schistosomes

eggs of ______ are nonoperculate, and irregularly ruptured in hatching

Schistosoma japonicum

more frequently found in the superior mesenteric veins draining the small intestine;

Oncomelania snails (Oncomelania hupensis quadrasi)

 intermediate hosts of S. japonicum

S. japonicum

 produce more eggs than the other schistosomes

S. japonicum

eggs are smaller and nearly spherical and may have a minute lateral spine

S. japonicum

animals, such as dogs, cats, rodents, pigs, horse and goats, serve as reservoirs for

S. mansoni

 occurs more often in the superior mesenteric veins draining the large intestine ; however, can occupy other location,

Schistosoma mansoni

Manson’s blood fluke

Biomphalaria snail

 intermediate host of S. mansoni

Schistosoma mansoni

 smallest of the schistosomes

Schistosoma mansoni

light yellowish brown, elongate, regularly ovoid -possess a large lateral spine, shaped like a rose thorn, which projects from the side of the egg near one pole

Schistosoma haematobium

bladder fluke

Schistosoma haematobium

cause urinary schistosomiasis

Bulinus snail

intermediate host of S. haematobium

Schistosoma heamatobium

 eggs contain fully developed miracidium when deposited


have a conspicuous terminal spine and are a light yellowish brown color

Schistosoma haematobium

 recommended time for collection: between noon and 3 PM

Schistosoma mekongi

from the Mekong River basin in Cambodia

Schistosoma hematobium

adult worms resemble S. japonicum but has smaller eggs

Schistosoma intercalatum

a schistosome in Western and Central Africa

Schistosoma intercalatum

adult worms are found in the mesenteric vessels, and eggs are voided in the feces

S. intercalatum

eggs closely resemble S. haematobium, but can be differentiated by a slight bend in the terminal spine


(egg shell is Ziehl-Neelsen positive

Swimmer's Itch

Itching and rash at site of invasion of the cercariae is often the first sign of infection, commonly known as ______

Granulomas

caused by deposits of eggs lodging in the small hepatic venules.

Urinary schistosomiasis

caused by S. haematobium – painful urination (dysuria), and blood in urine (hematuria).

Intestinal Schistosomiasis

caused by S. japonicum, S. mansoni


Large intestine is usually the focus of the infection. Victims experience abdominal pain and diarrhea that may be bloody.

Cerebral Schistosomiasis

most commonly caused by S. japonicum; egg deposits can cause local damage and legions in the CNS, or more severe problems rooted in capillary blockage and subsequent ischemia.

Swimmer’s itch (zoonosis)

cercariae of Schistosomes that usually parasitize mammals and birds enter human skin

Swimmer’s itch (zoonosis)

fork-tailed cercariae burrow into skin of human in water

treatment for schistosomiasis

praziquantel

Paragonimus wetermani

Oriental lung fluke

Paragonimus westermani

paragonimiasis or lung fluke disease, pulmonary distomiasis, endemic hemoptysis, or parasitic hemoptysis

Paragonimus westermani

paratenic hosts: swine, wild pigs

Paragonimus westermani

transmission is mainly attributed to the preparation of local delicacies

Paragonimus westermani adult

reddish brown and resembles a coffee bean

P.westermani adult

rounded anteriorly and slightly tapered posteriorly

Metacercaria of Paragonimus westermani.

This is the infective stage for the definitive, vertebrate host and is found in a crab or crayfish.

snail (Antemelania asperata and Antemelania dactylus)

-miracidium is the infective stage of this intermediate host

crustacean such as a crab or crayfish (Sundathelphusa philippina)

cercaria is the infective stage ( 2nd intermediate host of P.westermani)

P. westermani

reservoir hosts are dogs, cats, field rats and other rodents

cercariae

invade the crustacean and encyst into metacercariae

Paragonimus westermani


P. kellicotti

_______ is distributed in southeast Asia and Japan. ,_____ is endemic to North America.


Praziquantel


Bithionol

_____, drug of choice _____, alternative drug


for P.westermani


Fasciolopsis buski

largest intestinal fluke of human

Fasciolopsis buski

parasite of pigs

Fasciolopsis buski

seen in areas where humans raise pigs and consume freshwater plants

F. buski

lives in the duodenum

F. buski

elongated, oval in shape

Miracidium

infective to the first intermediate host (snail, Segmentina or Hippeutis)

Segmentina nitida (Shining ram's-horn snail)

1st intermediate host of F.buski

cercaria

infective to the second intermediate hosts (aquatic plants)


water caltrop


water chestnut


water morning glory


lotus

2nd intermediate host of F. buski


Trapa bicornis (_____), Eleocharis tuberosa (_____), Ipomea obscura(_____) Nymphaea (____)

Metacercaria( F. buski)

infective to definitive hosts (humans and pigs)

Metacercaria (F. buski)

sensitive to dryness

(S. mansoni, S. japonicum, S. mekongi, and intercalatum)

adult worms live in the blood vascular system, the eggs are generally found in the feces

S. haematobium

 although adult worms live in the blood vascular system, the eggs are generally found in the urine

Schistosomes

diecious, and the two sexes are dissimilar in appearance

schistosomiasis, bilharziasis, swamp fever

Disease names of schistosome

S.mansoni


S. haematobium


S. japonicum


S.mekongi


S. intercalatum

-found in parts of South America and the Caribbean, Africa, and the Middle East;


-in Africa and the Middle East; and


-in the Far East


East-


-are found focally in Southeast Asia


-central West Africa

Schistosomes (blood flukes)

 incomplete digestive system (presumed to absorb nutrients through the body wall)  ingest RBC


male testes (Schistosomes)

are arranged in one row above the ventral sucker

Schistosomes

 female has a single pyramidal ovary located in the midline

Schistosomes (egg)

 nonoperculate; can be ovoidal, rounded, or elongated  has a thin shell and may have a spine

Schistosomes

will hatch only in relatively clean water with sufficient oxygen

Schistosomes

will hatch only in relatively clean water with sufficient oxygen

Schistosomes

readily hatch in slightly alkaline water between 25 ℃ to 31 .

Miracidia ( Schistosomes )

with apical papilla, epidermal plates covered with cilia, a primitive gut, a pair of cephalic unicellular penetration glands, two pairs of flame cells, and germinal cells  phototactic and swim actively in surface water


Miracidia ( Schistosomes

 infective stage to the snail for some eight to twelve hours

Cercariae

 final development stage in the snail host, consisting of a body and a tail that aids in swimming after it leaves the snail  has an oral and small ventral sucker


Cercariae

 nocturnal release from early evening to midnight (can survive for 24 hours)


 penetration is stimulated by skin lipids and mediated by lytic enzymes secreted by cephalic glands and aided by muscular activity

Cercariae

 nocturnal release from early evening to midnight (can survive for 24 hours)


 penetration is stimulated by skin lipids and mediated by lytic enzymes secreted by cephalic glands and aided by muscular activity

Schistosomule

the immature schistosome in human tissues after the cercaria has lost the tail during penetration of the skin


 adapted to survive in serum or physiologic saline at 37

Schistosoma jqponicum

 oriental blood fluke

snail, aquatic plants

2 intermediate host of Faciolopsis buski

snail ,crab

2 intermediate host of Paragonimus westermani

praziquantel

treatment for F. buski

echinostomids

digenetic trematodes characterized by a collar of spines around their oral suckers.

Ichinostoma ilocanum/ Artyfechinostomum malayanum

definitive hosts: humans, dogs, cats, rats, pigs

Ichinostoma ilocanum/ Artyfechinostomum malayanum

rat is an important reservoir host

Ichinostoma ilocanum/ Artyfechinostomum malayanum

second intermediate hosts are abundant in rice fields especially during the wet months

ECHINOSTOMA ILOCANUM / ARTYFECHINOSTOMUM MALAYANUM

adults lives in small intestine

miracidium

 infects the first intermediate host (snail, for E. ilocanum: Gyraulus convexiusculus and Hippeutis umbilicalis

Echinostoma ilocanum

snail (Gyraulus convexiusculus and Hippeutis umbilicalis ) as first intermediate host

Cercaria

 infects the second intermediate host (snail, for E. ilocanum : Pila luzonica and Vivipara angularis; for A. malayanum : Lymnaea cumingiana)

snail: Pila luzonica and Vivipara angularis

2nd intermediate host of E.ilocanum

snail : Lymnaea cumingiana

2nd intermediate host of A. malayanum

Echinostoma ilocanum

 straw-colored, operculated, and ovoid

Artyfechinostomum malayanum

larger, golden brown, operculated

ECHINOSTOMA ILOCANUM / ARTYFECHINOSTOMUM MALAYANUM

two intermediate host 1. snail 2. snail


heterophyids

 intermediate hosts may be found in different habitats (fresh, brackish, and salt waters)

heterophyids

live in the intestines of fish-eating hosts.

Cercaria of Heterophyids

infective to the second intermediate host (fish)

Metacercaria of heterophyids

frequently found in the muscles at the base of the fin

heterophyids

two intermediate hosts 1. brackish water snail (for H. taichui: Melania juncea and Thiara riquetti; for other species of heterophyids in the Phils: unidentified) 2. Fish (tilapia, hito, bangus, lapu-lapu, etc.)


Heterphyes heterophyes

smallest trematode

Heterophyes heterophyes

has a third sucker, surrounding the genital pore

Heterophyes heterophyes

surface of the worm is covered with minute spines

Heterophyes heterophyes

Cerithidia and Pironella are important snail hosts

Heterephyes heterophyes

definitive host becomes infected by ingesting undercooked or salted fish containing metacercariae

 Cerithideopsilla cingulata

the main first intermediate host for H. heterophyes in southeast Asia

Metagonimus yokogawai

 snails of the genus Semisulcospira are the most frequent intermediate host

Metagonimus yokogawai

important distinctive feature is the position of the ventral sucker, which is to the side of the midline with its axis in a diagonal line

Nanophyetiasis

name of the disease caused by ingestion of the parasitic worm species Nanophyetus in humans.

Nanophyetiasis

labeled as the Fish Flu by several media outlets because of its usual method of transmission through infected fish.

Nanophyetus salmincola

is a food-born intestinal trematode endemic to the Northwestern United States and certain areas in Siberia. ,

Nanophyetus salmincola

Commonly called “Salmon Poisoning”, and hence the name salmincola.

Nanophyetiasis

Most commonly it is referred to as “Salmon Poisoning” or “Fish Flu” due to the fact that symptoms usually arise after the ingestion of fish, particularly salmonid species

Neorikettsia helminthoeca

salmon poisoning disease – caused by a rickettsia bacteria carried by the worm.

crypts of the small intestine

Site of infection of nanophyetiasis

Metacercaria of nanophyetiasis

salmonids are the most common host

Neorickettsia helminthoeca

agent of salmon poisoning in canids

Oxytrema silicula stream snail

miracidia of nanophyetiasis penetrate the first intermediate host ______

salmonid (some non-salmonid)

cercariae emerge from the snail and penetrate the second intermediate host, the _______fish.

Nanophyetiasis salmincola

light brown, ovoid, and operculate at one end, with a small blunt projection at the other end.

2 doses of bothionol or 3 doses of niclosamide


praziquantel

usual prescription for nanophyetiasis


, while _____ was effective in curing the disease

Fasciola hepatica


Fasciola gigantica

Fascioliasis is caused by the trematodes


________ (the sheep liver fluke or temperate liver fluke) and


_______ (tropical liver fluke), parasites of herbivores that can infect humans accidentally.


Faciola hepatica


Faciola gigantica

found in the liver and biliary passages of the definitive hosts

F. hepatica


F. gigantica

______: large, broad, and flat body


______: longer, and its shoulders are less developed


first intermediate host of Faciolopsis

snail- Lymnaea philippinensis and Lymnaea auricularia rubiginosa

aquatic plants

second intermediate host of fasciolopsis

F. hepatica

large, ovoidal, operculated, and yellowish to brownish (immature, containing a large unsegmented mass of vitelline cells when laid)

Fasciolopsis

two intermediate hosts 1. snail 2. aquatic plants

triclabendazole with bithionol as an alternative

Drug of choice for Fasciolopsis


____as alternative

Opistorchis viverrini

Southeast Asian liver fluke


 found mainly in northeast Thailand, Laos, and Kampuchea

Opistorchis felineus

cat liver fluke


found mainly in Europe and Asia, including the former Soviet Union


Clonorchis sinensis

Chinese or oriental liver fluke


- endemic areas are in Asia including Korea, China, Taiwan, and Vietnam


CLONORCHIS SINENSIS / OPISTHORCHIS FELINEUS / OPISTHORCHIS VIVERRINI

transmitted by consumption of raw, undercooked fish and salted, dried or pickled fresh water fish that are infected

liver flukes


CLONORCHIS SINENSIS / OPISTHORCHIS FELINEUS / OPISTHORCHIS VIVERRINI

parasites of the bile duct and gallbladder of humans and fish-eating mammals.

vitellaria


testes

main similarity between Clonorchis and Opisthorchis spp. is the location of the _____, whereas the main differences are in the morphology and arrangement of their ______

Liver flukes


CLONORCHIS SINENSIS / OPISTHORCHIS FELINEUS / OPISTHORCHIS VIVERRINI

leaf-like in shape with transparent tegument

miracidium

transforms into a sporocyst, which produces rediae, in turn produces cercariae

Cercaria

 infective stage to the second intermediate host (fish)


attaches to the epithelium of fish and encysts as a metacercaria under a scale or in a muscle

CLONORCHIS SINENSIS / OPISTHORCHIS FELINEUS / OPISTHORCHIS VIVERRINI

two intermediate hosts 1. snail 2. fish (family Cyprinidae) or shrimp


cholangiocarcinoma

 Chronic Opisthorchis viverrini infection is associated with _____ of the bile duct system, which can extend into the liver.


Praziquantel

is the drug of choice to treat Opisthorchiasis

Praziquantel or albendazole

are the drugs of choice for Clonorchiasis

6 days


5 hours


3 days


2 days


35 h


30 seconds


1 h

In vinegar, clonorchis died after ____; in a mix of vinegar and soybean sauce, it survived for ____; in wine it died after ___, also died after ____ in saturated saline solution; it was dead after ____ at –12°C and did not survive ____ in liquid nitrogen. It was still alive in large fish cooked for ____ at less than 80°C.

Dicrocoelium dendriticum

lanceolate fluke

Dicrocoelium dendriticum

trematode producing haepatobiliary damage (ending in cirrhosis) in sheep, hares and other herbivorous animals (rarely in humans).


Dicrocoelium dendriticus

Ruminants are the usual definitive hosts

Dicrocoelium dendriticum

Zebrina spp. and Cionella spp. ( snail) as the first intermediate host

Dicrocoelium dendriticum

ants may serve as the second intermediate host, especially members of the genus, Formica.

Zebrina detrita

common first intermediate host for D. dendriticum.

Formica fusca

a common second intermediate host for D. dendriticum in Europe

gonotyl

third sucker of trematodes observed in heterophyids

True

( T/F )


all trematodes require two intermediate host

Metacercaria

Encysted larva that serves as the infective stage for all trematodes, which develops in 2nd intermediate host

cercaria

infective stage of schistosomes

adult schistosomes calped blood flukes

found in upper mesenteric veins

Adult Paragonimus

found in lung parenchyma

Fasciola, Clonorchis, Opistorchis

Inhabit the liver and bile passages

Fasciolopsis, Echinostoma, heterophyids

inhabits the intestine

miracidium

a mature eggs contains embryo called miracidium

Schistosoma, Clonorchis , Opistorchis

eggs passed out by an infective host is mature

Paragonimus, faciolopsis, fasciola, echinostoma

eggs passed out by an infective host is immature

fresh water

Trematodes completes their life cycle in _____ snd require one or more intermediate host

False

eggs if schistosomes are operculated and irregulary ruptured in hatching