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8 Cards in this Set
- Front
- Back
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Drug: Acyclovir
What is the metabolism? |
Viral cells transform to active triphosphate form
Systemic elimination UNCHANGED by glomerular filtration and tubular secretion. |
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Drug: Amantadine
What is the metabolism? |
Systemic elimination unchanged by glomerular filtration and tubular secretion |
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Drug: Cidofovir
What is the metabolism? |
Metabolized via pyrimidine nucleoside monophosphate kinase to mono- & then diphosphate analogs and finally to monophosphate-choline
Systemic elimination by glomerular filtration and tubular secretion |
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Drug: Oseltamavir
What is the metabolism? |
Hepatically metabolized to the carboxylate active form of the drug.
Systemic elimination by glomerular filtration and tubular secretion. |
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Drug: Ribavirin
What is the metabolism? |
Undergoes non-CYP metabolism in nucleated cells with systemic elimination of drug and products in the urine. |
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Drug: Rimantadine
What is the metabolism? |
Extensive hepatic metabolism with renal elimination of drug & metabolites. |
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Drug: Valacyclovir
What is the metabolism? |
Converted to acyclovir (and L-valine) by 1st pass metabolism
Systemic elimination (acyclovir) by glomerular filtration and tubular secretion |
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Drug: Zanamivir
What is the metabolism? |
Renally eliminated unchanged |
