term1 Definition1term2 Definition2term3 Definition3
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Drug: Acyclovir
What is the metabolism?
Viral cells transform to active triphosphate form
Systemic elimination UNCHANGED by glomerular filtration and tubular secretion.
Drug: Amantadine
Systemic elimination unchanged by glomerular filtration and tubular secretion
Drug: Cidofovir
Metabolized via pyrimidine nucleoside monophosphate kinase to mono- & then diphosphate analogs and finally to monophosphate-choline
Systemic elimination by glomerular filtration and tubular secretion
Drug: Oseltamavir
Hepatically metabolized to the carboxylate active form of the drug.
Systemic elimination by glomerular filtration and tubular secretion.
Drug: Ribavirin
Undergoes non-CYP metabolism in nucleated cells with systemic elimination of drug and products in the urine.
Drug: Rimantadine
Extensive hepatic metabolism with renal elimination of drug & metabolites.
Drug: Valacyclovir
Converted to acyclovir (and L-valine) by 1st pass metabolism
Systemic elimination (acyclovir) by glomerular filtration and tubular secretion
Drug: Zanamivir
Renally eliminated unchanged
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