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11 Cards in this Set
- Front
- Back
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What are the forms of thrombolytic drugs most commonly used? How are they all given (oral or intravenously)?
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Tissue plasminogen activator
Streptokinase Intravelously |
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What are the t-PA drugs?
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Altepase, tenecteplase, and reteplase
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What is streptokinase derived from?
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Streptococci
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What does plasmin do?
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Endogenous fibronlytic enzyme that degrades clots by splitting fibrin into fragments.
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What doe the thombolytic enzymes catalyze?
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Conversion of inactive precursor plasminogen into plasmin.
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Mechanism of action of t-Pa (alteplase, reteplase, and tenecteplase)?
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Converts plasminogen into plasmin, which degrades the fibrin in thrombi
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What are the differences among alteplase, reteplase, and tenecteplase?
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Altepase = normal human plasminogen activator
Reteplase = mutated form of human t-PA (works faster, lasts longer) Tenecteplase = (longer half-life) |
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What is the mechanism of action of steptokinase?
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Bacterial protein that forms a complex with plasminogen that rapidly converts plasminogen to plasmin.
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True of false. Unlike the forms of t-PA, streptokinase does not show selectivity for fibrin-bound plasminogen.
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TRUE!
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What are the clinical uses of the thrombolytic drugs?
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Coronar artery thrombosis, ischemic stroke, pulmonary embolism
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What are toxicities of the thrombolytic drugs?
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Bleeding (esp. cerebral hemorrhage).
Streptokinase subject to inactivating antibodies and allergic reactions |
